TP53 mutation carrier estimation

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Documentation for package ‘LFSPRO’ version 1.0.5

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LFSPRO-package TP53 mutation carrier estimation
calLK Calculate the likelihood Pr(D|G).
cancer.data Cancer information data
cancer.type.all Predefined cancer types in LFSPRO.
CombineData Combine the family information data and cancer information data
fam.cancer.data Combined data with family and cancer information
fam.data Family information data
firstDegreeRelative First degree relatives
invasive.cut Cutoff for malignant cancer
lfs.cut Cutoff for Li-Fraumeni Syndrome spectrum cancer
LFSChompret The Chompret criteria for Li-Fraumeni syndrome
LFSChompret2015 The Chompret criteria for Li-Fraumeni syndrome
LFSClassic The Classic criteria for Li-Fraumeni syndrome
LFSpenet.2010 Penetrance for TP53 mutation
lfspro Estimating TP53 mutation probability for families with Li-Fraumeni Syndrome
LFSpro.cancer.type Predefined cancer types and the corresponding number in LFSpro
lfsproC Estimating TP53 mutation probability for families with Li-Fraumeni Syndrome for combined family and cancer data
lkNoneAffect Likelihood for non-affected individuals
peelingRC Peeling interface in R.
reformatForClassicChompret Reformat input data of LFSpro for evaluation using the Classic or the Chompret criteria
secondDegreeRelative Second degree relative