LFSChompret2015 {LFSPRO}R Documentation

The Chompret criteria for Li-Fraumeni syndrome

Description

Use LFS Chompret criteria 2015 version to find out the TP53 mutation carriers in the family.

Usage

LFSChompret2015(fam.data, cancer.data, counselee.id)

Arguments

fam.data

Family information data. See fam.data for details.

cancer.data

Cancer information data. See cancer.data for details.

counselee.id

Data frame including two variables: fam.id (family id of counselees) and id (individual id of counselees).

Value

A data frame of three columns:fam.id, id and result. The result column is a vector of boolean variables for all the counselees indicating whether they are TP53 mutation carriers. TRUE: carrier. FALSE: non-carrier.

Author(s)

Gang Peng

References

Chompret, A., et al. (2001). Sensitivity and predictive value of criteria for p53 germline mutation screening. J Med Genet, 38(1): 43-47.

Tinat, J., et al. (2009). 2009 version of the Chompret criteria for Li Fraumeni syndrome. J Clin Oncol, 27(26): e108-109.

Bougeard, G., et al.(2015). Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers. J Clin Oncol, 33(21): p. 2345-52.

See Also

LFSClassic, lfspro, LFSChompret

Examples

options(stringsAsFactors = FALSE)
fam.id <- c("fam1","fam2","fam2","fam2","fam2")
id <- c(0,0,2,100,200)
counselee.id <- data.frame(fam.id, id)
LFSChompret2015(fam.data, cancer.data, counselee.id)

[Package LFSPRO version 1.0.5 Index]