LFSChompret {LFSPRO} | R Documentation |
Use LFS Chompret criteria to find out the TP53 mutation carriers in the family.
LFSChompret(fam.data, cancer.data, counselee.id)
fam.data |
Family information data. See fam.data for details. |
cancer.data |
Cancer information data. See cancer.data for details. |
counselee.id |
Data frame including two variables: fam.id (family id of counselees) and id (individual id of counselees). |
A data frame of three columns:fam.id, id and result. The result column is a vector of boolean variables for all the counselees indicating whether they are TP53 mutation carriers. TRUE: carrier. FALSE: non-carrier.
Gang Peng
Chompret, A., et al. (2001). Sensitivity and predictive value of criteria for p53 germline mutation screening. J Med Genet, 38(1): 43-47.
Tinat, J., et al. (2009). 2009 version of the Chompret criteria for Li Fraumeni syndrome. J Clin Oncol, 27(26): e108-109; author reply e110.
options(stringsAsFactors = FALSE) fam.id <- c("fam1","fam2","fam2","fam2","fam2") id <- c(0,0,2,100,200) counselee.id <- data.frame(fam.id, id) LFSChompret(fam.data, cancer.data, counselee.id)