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ABL1 Gene

protein-coding GIFtS: 73

GC09P103075

c-abl oncogene 1, non-receptor tyrosine kinase
(Previous names: v-abl Abelson murine leukemia viral oncogene homolog 1, c-abl oncogene 1, receptor tyrosine kinase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABL)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
c-abl oncogene 1, non-receptor tyrosine kinase¹ ²		bcr/abl²
JTK7¹ ² ³		tyrosine-protein kinase ABL1²
p150¹ ² ³		v-abl²
v-abl Abelson murine leukemia viral oncogene homolog 1¹ ²		proto-oncogene tyrosine-protein kinase ABL1²
c-abl oncogene 1, receptor tyrosine kinase¹ ²		bcr/c-abl oncogene protein²
c-ABL¹ ²		Abelson murine leukemia viral oncogene homolog 1³
Proto-oncogene c-Abl² ³		EC 2.7.10.2³
ABL² ³

External Ids:	HGNC: 76¹	Entrez Gene: 25²	Ensembl: ENSG00000097007⁷	UniProtKB: P00519³

Export aliases for ABL1 gene to outside databases

Previous GC identifers: GC09P124604 GC09P125136 GC09P126943 GC09P128865 GC09P130619 GC09P132579 GC09P133589

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABL1:

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes

of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively

regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation

results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic

myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by

CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or

7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. (provided by RefSeq)

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519

Function: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton

remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and

phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair

potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates

PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks

summary for ABL1:

The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2)

subtypes. c-Abl is localized at several subcellular sites including the nucleus, cytoplasm, mitochondria and

endoplasmic reticulum, where it interacts with a large variety of cellular proteins including signaling

adaptors, kinases, phosphatases, cell cycle regulators, transcription factors and cytoskeletal proteins. Due

to its diverse range of targets, c-Abl has been implicated in many cellular processes including regulation

of cell growth and survival, oxidative stress and DNA-damage responses, and actin dynamics and cell

migration. The Abl family have significant structural homology to the Src tyrosine kinase family, but have a

unique long carboxy-terminal extension that contains protein-protein interaction sites and acts as the

binding site for targets such as ATM, p53 and pRb. c-Abl is medically important as there is a causal link

between the Abl-Bcr fusion protein (caused by a t(9,22) translocation) and development of chronic myeloid

leukemia.

Gene Wiki entry for ABL1 (Abl gene)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ABL1 gene promoter:
         STAT5B   STAT3   GATA-2   STAT1   STAT1beta   STAT1alpha   GATA-1   GATA-3   MyoD   C/EBPbeta
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ABL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ABL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.12 HGNC cytogenetic band: 9q34.1

ABL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABL1 gene location

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P103075: view genomic region (about GC identifiers)

Start:	103,075,969 bp from pter
End:	103,249,725 bp from pter
Size:	173,757 bases
Orientation:	plus strand

1 alternative location:

Chr9+ 133,589,333-133,763,062

RefSeq DNA sequence:

NC_000009.11 NT_035014.4

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519 (See protein sequence)

Recommended Name: Tyrosine-protein kinase ABL1

Size: 1130 amino acids; 122873 Da

Cofactor: Magnesium or manganese

Subunit: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and

CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.

Interacts with the 14-3-3 proteins, YWHAB, YWHAE, YWHAG, YWHAH, SFN AND YWHAZ; the interaction with 14-3-3 proteins

requires phosphorylation on Thr-735 and, sequesters ABL1 into the cytoplasm. Interacts with PSMA7

Subcellular location: Cytoplasm, cytoskeleton. Nucleus. Note=Sequestered into the cytoplasm through interaction with

14-3-3 proteins

Subcellular location: Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to

be nuclear

PDB structures from and Proteopedia :

1AB2 (3D)

1ABL (3D)

1AWO (3D)

1BBZ (3D)

1JU5 (3D)

1OPL (3D)

1ZZP (3D)

2ABL (3D)

2E2B (3D)

2F4J (3D)

2FO0 (3D)

2G1T (3D)

2G2F (3D)

2G2H (3D)

2G2I (3D)

2GQG (3D)

2HIW (3D)

2HYY (3D)

2HZ0 (3D)

2HZ4 (3D)

2HZI (3D)

2O88 (3D)

2V7A (3D)

3CS9 (3D)

3EG0 (3D)

3EG1 (3D)

3EG2 (3D)

3EG3 (3D)

3EGU (3D)

3K2M (3D)

Secondary accessions: A3KFJ3 Q13869 Q13870 Q16133 Q17R61 Q45F09

Alternative splicing: 2 isoforms: P00519-1 P00519-2

Explore the universe of human proteins at neXtProt for ABL1: NX_P00519

Post-translational modifications:

Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and

Ser-446 phosphorylation (By similarity). Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for

cytoplasmic translocation¹

Isoform IB is myristoylated on Gly-2¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005148.2 NP_009297.2

ENSEMBL proteins:

ENSP00000361423 ENSP00000400412 ENSP00000376971 ENSP00000323315 ENSP00000406308 ENSP00000407756

Human Recombinant Proteins

	Millipore Purified and/or Recombinant ABL1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ABL1
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): ABL1
	GenScript Custom Purified and Recombinant Proteins Services for ABL1
	Novus Biologicals Lysates for ABL1
	Sino Biological Recombinant Protein for ABL1
	Browse ProSpec Recombinant Proteins

5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	8242749
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	10892742
GO:0005856	cytoskeleton	IEA	--

About this table

ABL1 for ontologies About GeneDecksing

Antibodies for ABL1:

	Millipore Mono- and Polyclonal Antibodies for the study of ABL1
	Sigma-Aldrich Antibody Arrays and Antibodies for ABL1
	R&D Systems Antibodies for ABL1 (c-Abl)
	Cell Signaling Technology (CST) Antibodies for ABL1 (Abl)
	OriGene Antibodies: ABL1
	GenScript Superior Antibodies for ABL1
	Novus Biologicals Antibodies for ABL1
	Browse antibodies at Epitomics

Assays for ABL1:

	Millipore Kits and Assays for the Analysis of ABL1
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ABL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ABL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ABL1 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR017441 Protein_kinase_ATP_BS

IPR020685 Tyr_prot_kinase

IPR020700 Tyr_kinase_non-rcpt_Abl

IPR001245 Ser-Thr/Tyr-Pkinase

IPR011009 Kinase-like_dom

Graphical View of Domain Structure for InterPro Entry P00519

ProtoNet protein and cluster: P00519

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

Similarity: Contains 1 SH3 domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519

Function: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton

remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and

phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair

potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates

PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme regulation: Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker

region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and

phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by

RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of

chronic myeloid leukemia (CML). Inhibited by VX-680, an inhibitor that acts also on imanitib-resistant mutants

Enzyme Number (IUBMB): EC 2.7.10.2

Inhib. RNA:		Millipore RNAi Products for the Analysis of ABL1 Gene knock-down
		Sigma-Aldrich Nano Scale siRNA for ABL1 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ABL1 Sigma-Aldrich shRNA Panels and shRNA for ABL1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ABL1 OriGene shRNA RFP (see all 2): ABL1 OriGene basic RS shRNA (see all 2): ABL1 OriGene siRNA (see all 2): ABL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ABL1

miRNA:		Sigma-Aldrich microRNA Mimics for ABL1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ABL1
		7 SABiosciences Assays for microRNAs that regulate ABL1:
		hsa-miR-30c hsa-miR-196a hsa-miR-30a hsa-miR-196b hsa-miR-30b hsa-miR-30d hsa-miR-30e

Gene
Editing:

Sigma-Aldrich CompoZr Knockout ZFN for ABL1

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ABL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ABL1 OriGene untagged cDNA clones in CMV expression vector (see all 2): ABL1 OriGene 3'-UTR clone (see all 2): ABL1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): ABL1
		Sino Biological Human cDNA Clone for ABL1

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ABL1

Genatlas biochemistry entry for ABL1:

Abelson murine leukemia viral (v-abl) oncogene homolog 1,nucleocytoplasmic shuttling protein,with a loss from the

nucleus upon adhesion to fibronectin matrix,,activated by certain DNA-damaging agents from ionizing radiation to

alkylating agents,promoting cell cycle arrest by blocking the G/S transition-in a TP53 dependent way,regulated by

ATM,requiring mitogen-activated protein kinase kinase 6 activation (MAP2K6) for inducing apoptosis,activating TP73 in

a mismatch repair dependent apoptosis pathway and MAP2K6 (for CABL induced apoptosis)

5/16 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 16):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IDA	9144171
GO:0003677	DNA binding	NAS	8242749
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	--	--

About this table

ABL1 for ontologies About GeneDecksing

Animal Models: 15/19 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Abl1) (see all 19):

cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	muscle	nervous system

ABL1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

ABL1 for pathways About GeneDecksing

5 Millipore Pathways for ABL1

	Transcription Transcription factor Tubby signaling pathways
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling Slit-Robo signaling
	DNA damage DNA-damage-induced responses
	Signal transduction Activation of PKC via G-Protein coupled receptor

5/22 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for ABL1 (see all 22)

	Cell Cycle: G1/S Checkpoint Regulation
	Ephrin Receptor Signaling
	CDK5 Signaling
	Caveolar-mediated Endocytosis Signaling
	PDGF Signaling

5 Cell Signaling Technology (CST) Pathways for ABL1

	Cell Cycle Control: G2/M DNA Damage Checkpoint
	Translational Control: Regulation of eIF4E and p70 S6 Kinase
	B Cell Receptor Signaling
	Protein Acetylation
	Cell Cycle Control: G1/S Checkpoint

5/9 Kegg Pathways (Kegg details for ABL1) (see all 9):

	hsa04012 ErbB signaling pathway
	hsa04110 Cell cycle
	hsa04360 Axon guidance
	hsa04722 Neurotrophin signaling pathway
	hsa05130 Pathogenic Escherichia coli infection

SABiosciences Pathway-Focused PCR Arrays including ABL1 (see all 8): PAHS-012A PAHS-020A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ABL1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ABL1

5/254 Interacting proteins for ABL1 (ENSP00000361423³ P00519^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 254)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABI1	Q8IZP0¹^,²	STRING: ENSP00000347555 EBI-375543,EBI-375446 MINT-7385805 MINT-7385781 MINT-3390323 MINT-7907945 MINT-7385753 MINT-7385822 MINT-7385733 MINT-3390262
RIN1	Q13671¹^,²	STRING: ENSP00000310406 EBI-375543,EBI-366017 MINT-59466 MINT-8034725 MINT-59455 MINT-59454
MAP4K1	Q92918¹^,²	STRING: ENSP00000221409 EBI-375543,EBI-881 MINT-7244806 MINT-7243318 MINT-7213035
CRK	P46108¹^,²	STRING: ENSP00000300574 EBI-375543,EBI-886 MINT-7254106 MINT-8036825
NCK1	P16333¹^,²	STRING: ENSP00000288986 EBI-375543,EBI-389883 MINT-7247638 MINT-7249642

About this table

5/14 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 14):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	TAS	8242749
GO:0006298	mismatch repair	TAS	10391249
GO:0006355	regulation of transcription, DNA-dependent	TAS	8242749
GO:0006464	protein modification process	NAS	8242749
GO:0006468	protein phosphorylation	--	--

About this table

ABL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

ABL1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Enzo Life Sciences drugs & compounds for ABL1

Compounds for ABL1 available from Tocris Bioscience

Compound	Action	CAS number
1-Naphthyl PP1	Src family kinase inhibitor; also inhibits c-Abl	[221243-82-9]

About this table

10/44 Novoseek chemical compound relationships for ABL1 gene (see all 44)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
imatinib	91.7	281	18835981 (5), 20020482 (5), 16205964 (3), 15510830 (3) (see all 99)
tyrosine	87.4	511	9988744 (4), 11279131 (4), 11781820 (4), 11494128 (4) (see all 99)
dasatinib	78.7	22	17155893 (2), 19062342 (2), 18326784 (2), 16721371 (1) (see all 10)
adaphostin	66.7	5	17308109 (2), 17252018 (1)
phosphotyrosine	65.4	15	1712111 (3), 12654250 (2), 8912843 (1), 10708759 (1) (see all 12)
rottlerin	40.4	6	11707430 (1), 20043988 (1), 10713049 (1), 16631755 (1)
phosphatidylinositol	40.2	17	9295282 (4), 16867995 (3), 1846663 (2), 14555967 (1) (see all 11)
threonine	34.4	5	8691423 (1), 10637231 (1), 11840343 (1), 8816443 (1) (see all 5)
cytarabine	30.6	11	8900110 (3), 8530447 (2), 12021410 (2), 9365241 (1)
herbimycin a	28.6	2	1564963 (1), 8510919 (1)

About this table

2 PharmGKB drug compound relationships for ABL1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
imatinib	CO PD	15758023
imatinib mesylate 100mg cap	PD GN	15243647

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Millipore RNAi Products for the Analysis of ABL1 Gene knock-down
		Sigma-Aldrich Nano Scale siRNA for ABL1 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ABL1 Sigma-Aldrich shRNA Panels and shRNA for ABL1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ABL1 OriGene shRNA RFP (see all 2): ABL1 OriGene basic RS shRNA (see all 2): ABL1 OriGene siRNA (see all 2): ABL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ABL1

miRNA:		Sigma-Aldrich microRNA Mimics for ABL1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ABL1
		7 SABiosciences Assays for microRNAs that regulate ABL1:
		hsa-miR-30c hsa-miR-196a hsa-miR-30a hsa-miR-196b hsa-miR-30b hsa-miR-30d hsa-miR-30e

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ABL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ABL1 OriGene untagged cDNA clones in CMV expression vector (see all 2): ABL1 OriGene 3'-UTR Clone (see all 2): ABL1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): ABL1

Primers:		OriGene genome-wide validated SYBR primer pairs: ABL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ABL1: PPH00087A

REFSEQ mRNAs for ABL1 gene (2 alternative transcripts):

NM_005157.3 NM_007313.2

Additional cDNA sequence:

AB209456.1 AB209642.1 AF533988.1 AK095344.1 AK294983.1 AM491359.1 AM491361.1 AY043457.1

AY789120.1 BC107069.1 BC107070.1 BC117451.1 CR598308.1 CR614023.1 DQ898314.1 EF158045.1

EF423615.1 EU447303.1 M13096.1 M14752.1 M14753.1 M14754.1 M25946.1 M30833.1

X07537.1 X16416.1 X51945.1

16 DOTS entries:

DT.75139099 DT.91761963 DT.121201653 DT.40199015 DT.100033850 DT.121201747 DT.121201672 DT.121201745

DT.97817099 DT.95079826 DT.95228147 DT.87017796 DT.100734507 DT.121201744 DT.91724158 DT.95129497

24/43 AceView cDNA sequences (see all 43):

AK095344 BM832613 BX099890 CR614023 AL134822 AL707819 CR598308 NM_007313

X16416 BX097261 AA687347 CA335983 AI025543 AW206835 H81821 AI084206

BQ772414 AA889856 BG955635 AI475681 X51945 NM_005157 M14753 M14752

highest scoring ESTs for ABL1:

T47234 X16416 AA115473 AA115607 AA227275 AA227276 AA296072 AA325255 AA335336 AA335349

Unigene Cluster for ABL1:

C-abl oncogene 1, non-receptor tyrosine kinase

Hs.431048 [show with all ESTs]

Unigene Representative Sequence: NM_007313

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372348 ENST00000444970 ENST00000393293 ENST00000318560(uc004bzv.2 uc004bzw.2)

ENST00000426772 ENST00000438426

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ABL1 expression in normal and diseased human tissues

¹ / ² / ³

9 probe-sets matching ABL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2041_i_at²^{, 3}	U95-A	1	1.00	1.00	0.17	0.62	M14752	0.80	1.00	0.91	1
2040_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.17	0.54	M14752	0.80	1.00	0.91	1
1656_s_at²^{, 3}	U95-A	1	1.00	1.00	0.77	0.46	U07563	0.20	0.50	0.38	1
1636_g_at²^{, 3}	U95-A	1	0.94	1.00	0.88	1.38	U07563	0.20	0.50	0.38	1
1635_at²^{, 3}	U95-A	1	0.94	1.00	0.82	1.17	U07563	0.20	0.50	0.38	1
52316_s_at²^{, 3}	U95-B	1	0.81	1.00	0.77	1.55	T47234	1.00	1.00	1.00	1
39730_at²^{, 3}	U95-A	1	0.75	1.00	0.88	1.32	X16416	1.00	1.00	1.00	1
202123_s_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_005157	0.60	1.00	0.82	1
202123_s_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

ABL1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ABL1 gene electronic northern expression

About these images

CGAP SAGE TAG: AGGTACTGGT

SOURCE GeneReport for Unigene cluster: Hs.431048

Expression variation in blood from EXPOLDB for ABL1

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519

Tissue specificity: Widely expressed

Primers:		OriGene genome-wide validated SYBR primer pairs: ABL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ABL1: PPH00087A

SABiosciences Expression via Pathway-Focused PCR Arrays including ABL1 (see all 8): PAHS-012A PAHS-020A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ABL1 gene from 5/10 species (see all 10)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ABL1¹	--	c-abl oncogene 1, receptor tyrosine kinase	88.24(n) 91.48(a)	491292 XM_548413.2 XP_548413.2
chimpanzee (Pan troglodytes)	ABL1¹	--	c-abl oncogene 1, receptor tyrosine kinase	99.54(n) 99.91(a)	464802 XM_001166213.1 XP_001166213.1
cow (Bos taurus)	ABL1¹	--	c-abl oncogene 1, receptor tyrosine kinase	87.43(n) 91.45(a)	540876 XM_613548.3 XP_613548.2
rat (Rattus norvegicus)	Abl1¹	--	c-abl oncogene 1, receptor tyrosine kinase	85.24(n) 89.02(a)	311860 XM_001067860.1 XP_001067860.1
mouse (Mus musculus)	Abl1^{1 , 5}	2 (21.86 cM)⁵	c-abl oncogene 1, non-receptor tyrosine kinase⁵ c-abl oncogene 1, receptor tyrosine kinase¹	84.81(n)¹ 88.38(a)¹	11350¹ NM_009594.2¹ NP_033724.1¹ AI325092⁵ AK037887⁵ (see all 41)

About this table Species with no ortholog for ABL1

ENSEMBL Gene Tree for ABL1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ABL1 gene

TEC² BMX² ABL2² SRMS² ITK² PTK6² TXK² BTK²

ABL1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
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SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs7457^1,2	C,F,O,A,	133762826(+)	`GTTAAC/TGTGAT`	2	--	ut3¹		19	MN NS EA NA WA	1430
rs9762^1,2	C,F,A,H,	133762553(+)	`TTCCCA/GCCCCT`	2	--	ut3¹ ese³		9	NS NA WA	198
rs10753^1,2	--	133761923(+)	`GGCAGG/AGGACA`	2	--	ut3¹ ese³		1	MN	184
rs11991^1,2	C,F,A,	133762558(+)	`ACCCCT/CTCATA`	2	--	ut3¹ ese³		17	MN NS EA NA WA	1104
rs913721^1,2	C,A,	133645683(+)	`gaagcT/Cgggag`	1	--	int¹		4	NA WA	8
rs946486^1,2	C,F,O,A,	133646005(-)	`GCCAAG/ATAATT`	1	--	int¹		20	NA NS EA WA	1204
rs1056169^1,2	C,	133760677(+)	`TCCACC/TGCCTT`	4	T	ref¹ syn¹ ese³		5	NS	190
rs1056171^1,2	C,F,H,	133761001(+)	`GGTCCG/AGCGGC`	4	/P	ref¹ syn¹ ese³		19	MN NS NA WA	1046
rs1056174^1,2	C	133761139(+)	`TACCCG/ATGACA`	2	--	ut3¹ ese³		5	NS	190
rs1056209^1,2	C,F,O,	133762590(+)	`GCACAG/AGCCCT`	2	--	ut3¹ ese³		14	MN NS EA NA WA	866

About this table

HapMap Linkage Disequilibrium images for ABL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for ABL1
7 CNVs: 3782 96316 83198 96318 7726 83199 96320
6 Indels: 96319 96317 96321 29063 65533 83200

QIAGEN SeqTarget long-range PCR primers for resequencing ABL1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ABL1 for disorders About GeneDecksing

OMIM: 189980

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519

Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation

t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute

lymphoblastic leukemia (ALL)

10/55 Novoseek disease relationships for ABL1 gene (see all 55)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	91.9	112	18243808 (3), 2157692 (2), 16825513 (2), 7718887 (2) (see all 97)
blast crisis	79.7	14	10822991 (2), 10190307 (2), 10498618 (2), 12759927 (2) (see all 7)
leukemia	77.8	84	18257513 (3), 9341866 (3), 2163816 (2), 17959833 (2) (see all 67)
lymphoblastic leukemia acute	70.4	12	8242587 (1), 8632666 (1), 11801308 (1), 15964830 (1) (see all 12)
cml chronic phase	67.7	2	1736009 (1)
myeloproliferative disorders	65.1	11	10490629 (2), 12767088 (1), 9490692 (1), 15616602 (1) (see all 8)
minimal residual disease	62.2	1	16213363 (1)
myeloproliferative neoplasm	59.2	4	18971950 (1), 19175693 (1)
leukemogenesis	56.9	12	11387320 (2), 9790503 (1), 12887890 (1), 20082857 (1) (see all 7)
gastrointestinal stromal tumor	54.4	4	15637141 (1), 15717993 (1), 15727903 (1), 18553235 (1)

About this table

3 PharmGKB disease relationships for ABL1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Diabetes Mellitus, Non-Insulin-Dependent	CO PD	15758023
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115
Leukemia, Myeloid, Chronic	PD GN	15243647

About this table

Genetic Association Database (GAD): ABL1
Human Genome Epidemiology (HuGE) Navigator: ABL1 (15 documents)
Tumor Gene Database (TGDB): ABL1

Export disorders and mutations for ABL1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

Study Identifies New Type of Childhood ALL Associated With Poor Treatment Outcome

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/1040 PubMed articles for ABL1 gene, integrated from 7 sources (see all 1040):
(articles sorted by number of sources associating them with ABL1)

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)^{1, 2, 7} Yoshida K.... Miki Y. (2005)
Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. (PubMed id 7665185)^{1, 2, 7} Chissoe S.L.... Roe B.A. (1995)
Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104)^{1, 2, 7} Liu X....Cao C. (2006)
Role of interfacial water molecules in proline-rich l igand recognition by the Src homology 3 domain of Abl. (PubMed id 19906645)^{1, 2, 7} Palencia A....Luque I. (2010)
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. (PubMed id 10194451)^{1, 2, 7} Wisniewski D.... Clarkson B. (1999)
Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution. (PubMed id 1281542)^{1, 2, 7} Overduin M.... Cowburn D. (1992)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{1, 2} Wissing J.... Daub H. (2007)
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. (PubMed id 16543148)^{1, 2} Nagar B.... Kuriyan J. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
A single nucleotide polymorphism in the coding region of ABL and its effects on sensitivity to imatinib. (PubMed id 16151465)^{1, 4} Crossman L.C....Deininger M.W. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25	HGNC: 76	AceView: ABL1	Ensembl:ENSG00000097007	euGenes: HUgn25
ECgene: ABL1	Kegg: 25	H-InvDB: ABL1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ABL1	Genetics and Cytogenetics in Oncology and Haematology
CGP resequencing studies	http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ABL1
NIEHS-SNPs	http://egp.gs.washington.edu/data/abl1/
Wikipedia	http://en.wikipedia.org/wiki/Abl_gene

Intellectual Property for ABL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ABL1 gene:
Search GeneIP for patents involving ABL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Antibodies & Assays for ABL1 (Abl)

	Regulatory tfbs in ABL1 promoter
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protein-coding GIFtS: 73

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