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ABL1 Gene

protein-coding   GIFtS: 73

GC09P103075
c-abl oncogene 1, non-receptor tyrosine kinase
(Previous names: v-abl Abelson murine leukemia viral oncogene homolog 1, c-abl oncogene 1, receptor tyrosine kinase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABL)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
c-abl oncogene 1, non-receptor tyrosine kinase1 2     bcr/abl2
JTK71 2 3     tyrosine-protein kinase ABL12
p1501 2 3     v-abl2
v-abl Abelson murine leukemia viral oncogene homolog 11 2     proto-oncogene tyrosine-protein kinase ABL12
c-abl oncogene 1, receptor tyrosine kinase1 2     bcr/c-abl oncogene protein2
c-ABL1 2     Abelson murine leukemia viral oncogene homolog 13
Proto-oncogene c-Abl2 3     EC 2.7.10.23
ABL2 3     

External Ids:    HGNC: 761   Entrez Gene: 252   Ensembl: ENSG000000970077   UniProtKB: P005193   

Export aliases for ABL1 gene to outside databases

Previous GC identifers: GC09P124604 GC09P125136 GC09P126943 GC09P128865 GC09P130619 GC09P132579 GC09P133589


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ABL1:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes
of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively
regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation
results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic
myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by
CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or
7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. (provided by RefSeq)

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
Function: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton
remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and
phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair
potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates
PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks

summary for ABL1:
The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2)
subtypes. c-Abl is localized at several subcellular sites including the nucleus, cytoplasm, mitochondria and
endoplasmic reticulum, where it interacts with a large variety of cellular proteins including signaling
adaptors, kinases, phosphatases, cell cycle regulators, transcription factors and cytoskeletal proteins. Due
to its diverse range of targets, c-Abl has been implicated in many cellular processes including regulation
of cell growth and survival, oxidative stress and DNA-damage responses, and actin dynamics and cell
migration. The Abl family have significant structural homology to the Src tyrosine kinase family, but have a
unique long carboxy-terminal extension that contains protein-protein interaction sites and acts as the
binding site for targets such as ATM, p53 and pRb. c-Abl is medically important as there is a causal link
between the Abl-Bcr fusion protein (caused by a t(9,22) translocation) and development of chronic myeloid
leukemia.

Gene Wiki entry for ABL1 (Abl gene)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ABL1 gene promoter:
         STAT5B   STAT3   GATA-2   STAT1   STAT1beta   STAT1alpha   GATA-1   GATA-3   MyoD   C/EBPbeta   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ABL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ABL1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.12   HGNC cytogenetic band: 9q34.1

ABL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ABL1 gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P103075:  view genomic region     (about GC identifiers)

Start:
103,075,969 bp from pter
End:
103,249,725 bp from pter
Size:
173,757 bases
Orientation:
plus strand

1 alternative location:
Chr9+ 133,589,333-133,763,062     
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519 (See protein sequence)
Recommended Name: Tyrosine-protein kinase ABL1  
Size: 1130 amino acids; 122873 Da
Cofactor: Magnesium or manganese
Subunit: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and
CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.
Interacts with the 14-3-3 proteins, YWHAB, YWHAE, YWHAG, YWHAH, SFN AND YWHAZ; the interaction with 14-3-3 proteins
requires phosphorylation on Thr-735 and, sequesters ABL1 into the cytoplasm. Interacts with PSMA7
Subcellular location: Cytoplasm, cytoskeleton. Nucleus. Note=Sequestered into the cytoplasm through interaction with
14-3-3 proteins
Subcellular location: Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to
be nuclear
PDB structures from and Proteopedia :
1AB2 (3D)    1ABL (3D)    1AWO (3D)    1BBZ (3D)    1JU5 (3D)    1OPL (3D)    1ZZP (3D)    2ABL (3D)    
2E2B (3D)    2F4J (3D)    2FO0 (3D)    2G1T (3D)    2G2F (3D)    2G2H (3D)    2G2I (3D)    2GQG (3D)    
2HIW (3D)    2HYY (3D)    2HZ0 (3D)    2HZ4 (3D)    2HZI (3D)    2O88 (3D)    2V7A (3D)    3CS9 (3D)    
3EG0 (3D)    3EG1 (3D)    3EG2 (3D)    3EG3 (3D)    3EGU (3D)    3K2M (3D)    
Secondary accessions: A3KFJ3 Q13869 Q13870 Q16133 Q17R61 Q45F09
Alternative splicing: 2 isoforms:  P00519-1   P00519-2   

Explore the universe of human proteins at neXtProt for ABL1: NX_P00519 

Post-translational modifications:

  • Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and
  • Ser-446 phosphorylation (By similarity). Phosphorylation on Thr-735 is required for binding 14-3-3 proteins for
    cytoplasmic translocation1
  • Isoform IB is myristoylated on Gly-21
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_005148.2  NP_009297.2  


    ENSEMBL proteins: 
    ENSP00000361423 ENSP00000400412 ENSP00000376971 ENSP00000323315 ENSP00000406308 ENSP00000407756 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant ABL1 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ABL1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): ABL1
    GenScript Custom Purified and Recombinant Proteins Services for ABL1 
    Novus Biologicals Lysates for ABL1
    Sino Biological Recombinant Protein for ABL1
    Browse ProSpec Recombinant Proteins

    5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS8242749
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol EXP10892742
    GO:0005856 cytoskeleton IEA--
    About this table

    ABL1 for ontologies           About GeneDecksing



    Antibodies for ABL1: 
    Millipore Mono- and Polyclonal Antibodies for the study of ABL1
    Sigma-Aldrich Antibody Arrays and Antibodies for ABL1
    R&D Systems Antibodies for ABL1 (c-Abl)
    Cell Signaling Technology (CST) Antibodies for ABL1  (Abl)
    OriGene Antibodies: ABL1
    GenScript Superior Antibodies for ABL1 
    Novus Biologicals Antibodies for ABL1
    Browse antibodies at Epitomics

    Assays for ABL1: 
    Millipore Kits and Assays for the Analysis of ABL1
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ABL1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ABL1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ABL1 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR020685 Tyr_prot_kinase
     IPR020700 Tyr_kinase_non-rcpt_Abl
     IPR001245 Ser-Thr/Tyr-Pkinase
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P00519

    ProtoNet protein and cluster: P00519

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
    Function: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton
    remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and
    phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair
    potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates
    PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker
    region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and
    phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by
    RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of
    chronic myeloid leukemia (CML). Inhibited by VX-680, an inhibitor that acts also on imanitib-resistant mutants
    Enzyme Number (IUBMB): EC 2.7.10.2 

    Inhib.
    RNA:
        
    Millipore RNAi Products for the Analysis of ABL1 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for ABL1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ABL1
    Sigma-Aldrich shRNA Panels and shRNA for ABL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ABL1
    OriGene shRNA RFP (see all 2): ABL1
    OriGene basic RS shRNA (see all 2): ABL1
    OriGene siRNA (see all 2): ABL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ABL1 
    miRNA:Sigma-Aldrich microRNA Mimics for ABL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ABL1 
    7 SABiosciences Assays for microRNAs that regulate ABL1:
    hsa-miR-30c hsa-miR-196a hsa-miR-30a hsa-miR-196b hsa-miR-30b hsa-miR-30d hsa-miR-30e

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for ABL1 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene 3'-UTR clone (see all 2): ABL1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): ABL1 
    Sino Biological Human cDNA Clone for ABL1

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ABL1 

    Genatlas biochemistry entry for ABL1:
    Abelson murine leukemia viral (v-abl) oncogene homolog 1,nucleocytoplasmic shuttling protein,with a loss from the
    nucleus upon adhesion to fibronectin matrix,,activated by certain DNA-damaging agents from ionizing radiation to
    alkylating agents,promoting cell cycle arrest by blocking the G/S transition-in a TP53 dependent way,regulated by
    ATM,requiring mitogen-activated protein kinase kinase 6 activation (MAP2K6) for inducing apoptosis,activating TP73 in
    a mismatch repair dependent apoptosis pathway and MAP2K6 (for CABL induced apoptosis)

    5/16 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 16):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IDA9144171
    GO:0003677 DNA binding NAS8242749
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    About this table

    ABL1 for ontologies           About GeneDecksing

    Animal Models: 15/19 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Abl1) (see all 19):

    cardiovascular systemcellularcraniofacialdigestive/alimentaryembryogenesis
    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
    lethality-prenatal/perinatallife span-post-weaning/agingliver/biliary systemmusclenervous system

    ABL1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ABL1 for pathways           About GeneDecksing

    5 Millipore Pathways for ABL1
        Transcription Transcription factor Tubby signaling pathways
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Slit-Robo signaling
    DNA damage DNA-damage-induced responses
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/22 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  ABL1 (see all 22)
        Cell Cycle: G1/S Checkpoint Regulation
    Ephrin Receptor Signaling
    CDK5 Signaling
    Caveolar-mediated Endocytosis Signaling
    PDGF Signaling

    5 Cell Signaling Technology (CST) Pathways for ABL1
        Cell Cycle Control: G2/M DNA Damage Checkpoint
    Translational Control: Regulation of eIF4E and p70 S6 Kinase
    B Cell Receptor Signaling
    Protein Acetylation
    Cell Cycle Control: G1/S Checkpoint

    5/9 Kegg Pathways  (Kegg details for ABL1) (see all 9):
        hsa04012 ErbB signaling pathway
    hsa04110 Cell cycle
    hsa04360 Axon guidance
    hsa04722 Neurotrophin signaling pathway
    hsa05130 Pathogenic Escherichia coli infection

        SABiosciences Pathway-Focused PCR Arrays including ABL1 (see all 8): PAHS-012A PAHS-020A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ABL1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ABL1

    5/254 Interacting proteins for ABL1 (ENSP000003614233 P005191, 2) via UniProtKB, MINT, and/or STRING (see all 254)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI1Q8IZP01, 2STRING: ENSP00000347555 EBI-375543,EBI-375446 MINT-7385805 MINT-7385781 MINT-3390323 MINT-7907945 MINT-7385753 MINT-7385822 MINT-7385733 MINT-3390262
    RIN1Q136711, 2STRING: ENSP00000310406 EBI-375543,EBI-366017 MINT-59466 MINT-8034725 MINT-59455 MINT-59454
    MAP4K1Q929181, 2STRING: ENSP00000221409 EBI-375543,EBI-881 MINT-7244806 MINT-7243318 MINT-7213035
    CRKP461081, 2STRING: ENSP00000300574 EBI-375543,EBI-886 MINT-7254106 MINT-8036825
    NCK1P163331, 2STRING: ENSP00000288986 EBI-375543,EBI-389883 MINT-7247638 MINT-7249642
    About this table

    5/14 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 14):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle TAS8242749
    GO:0006298 mismatch repair TAS10391249
    GO:0006355 regulation of transcription, DNA-dependent TAS8242749
    GO:0006464 protein modification process NAS8242749
    GO:0006468 protein phosphorylation ----
    About this table

    ABL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ABL1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Enzo Life Sciences drugs & compounds for ABL1

    Compounds for ABL1 available from Tocris Bioscience
    CompoundAction CAS number
    1-Naphthyl PP1Src family kinase inhibitor; also inhibits c-Abl[221243-82-9]
    About this table


    10/44 Novoseek chemical compound relationships for ABL1 gene (see all 44)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imatinib 91.7 281 18835981 (5), 20020482 (5), 16205964 (3), 15510830 (3) (see all 99)
    tyrosine 87.4 511 9988744 (4), 11279131 (4), 11781820 (4), 11494128 (4) (see all 99)
    dasatinib 78.7 22 17155893 (2), 19062342 (2), 18326784 (2), 16721371 (1) (see all 10)
    adaphostin 66.7 5 17308109 (2), 17252018 (1)
    phosphotyrosine 65.4 15 1712111 (3), 12654250 (2), 8912843 (1), 10708759 (1) (see all 12)
    rottlerin 40.4 6 11707430 (1), 20043988 (1), 10713049 (1), 16631755 (1)
    phosphatidylinositol 40.2 17 9295282 (4), 16867995 (3), 1846663 (2), 14555967 (1) (see all 11)
    threonine 34.4 5 8691423 (1), 10637231 (1), 11840343 (1), 8816443 (1) (see all 5)
    cytarabine 30.6 11 8900110 (3), 8530447 (2), 12021410 (2), 9365241 (1)
    herbimycin a 28.6 2 1564963 (1), 8510919 (1)
    About this table

    2 PharmGKB drug compound relationships for ABL1 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    imatinibCO  PD  15758023
    imatinib mesylate 100mg capPD  GN  15243647
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Millipore RNAi Products for the Analysis of ABL1 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for ABL1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ABL1
    Sigma-Aldrich shRNA Panels and shRNA for ABL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ABL1
    OriGene shRNA RFP (see all 2): ABL1
    OriGene basic RS shRNA (see all 2): ABL1
    OriGene siRNA (see all 2): ABL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ABL1 
    miRNA: Sigma-Aldrich microRNA Mimics for ABL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ABL1 
    7 SABiosciences Assays for microRNAs that regulate ABL1:
    hsa-miR-30c hsa-miR-196a hsa-miR-30a hsa-miR-196b hsa-miR-30b hsa-miR-30d hsa-miR-30e
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ABL1
    OriGene 3'-UTR Clone (see all 2): ABL1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): ABL1 
    Primers: OriGene genome-wide validated SYBR primer pairs: ABL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ABL1: PPH00087A

    REFSEQ mRNAs for ABL1 gene (2 alternative transcripts): 

    NM_005157.3  NM_007313.2  

    Additional cDNA sequence: 

    AB209456.1 AB209642.1 AF533988.1 AK095344.1 AK294983.1 AM491359.1 AM491361.1 AY043457.1 
    AY789120.1 BC107069.1 BC107070.1 BC117451.1 CR598308.1 CR614023.1 DQ898314.1 EF158045.1 
    EF423615.1 EU447303.1 M13096.1 M14752.1 M14753.1 M14754.1 M25946.1 M30833.1 
    X07537.1 X16416.1 X51945.1 

    16 DOTS entries:

    DT.75139099  DT.91761963  DT.121201653  DT.40199015  DT.100033850  DT.121201747  DT.121201672  DT.121201745 
    DT.97817099  DT.95079826  DT.95228147  DT.87017796  DT.100734507  DT.121201744  DT.91724158  DT.95129497 

    24/43 AceView cDNA sequences (see all 43):

    AK095344 BM832613 BX099890 CR614023 AL134822 AL707819 CR598308 NM_007313 
    X16416 BX097261 AA687347 CA335983 AI025543 AW206835 H81821 AI084206 
    BQ772414 AA889856 BG955635 AI475681 X51945 NM_005157 M14753 M14752 

    highest scoring ESTs for ABL1:

    T47234 X16416 AA115473 AA115607 AA227275 AA227276 AA296072 AA325255 AA335336 AA335349 

    Unigene Cluster for ABL1:

    C-abl oncogene 1, non-receptor tyrosine kinase
    Hs.431048  [show with all ESTs]
    Unigene Representative Sequence: NM_007313


    GeneLoc Exon Structure

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372348 ENST00000444970 ENST00000393293 ENST00000318560(uc004bzv.2 uc004bzw.2)
    ENST00000426772 ENST00000438426

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ABL1 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching ABL1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    2041_i_at2, 3 U95-A 1 1.00 1.00 0.17 0.62 M14752 0.80 1.00 0.91 1
    2040_s_at2, 3 U95-A 1 1.00 1.00 -0.17 0.54 M14752 0.80 1.00 0.91 1
    1656_s_at2, 3 U95-A 1 1.00 1.00 0.77 0.46 U07563 0.20 0.50 0.38 1
    1636_g_at2, 3 U95-A 1 0.94 1.00 0.88 1.38 U07563 0.20 0.50 0.38 1
    1635_at2, 3 U95-A 1 0.94 1.00 0.82 1.17 U07563 0.20 0.50 0.38 1
    52316_s_at2, 3 U95-B 1 0.81 1.00 0.77 1.55 T47234 1.00 1.00 1.00 1
    39730_at2, 3 U95-A 1 0.75 1.00 0.88 1.32 X16416 1.00 1.00 1.00 1
    202123_s_at2, 3 U133-A 1 0.73 1.00 -- -- NM_005157 0.60 1.00 0.82 1
    202123_s_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    ABL1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ABL1 gene expression
    ABL1 gene electronic northern expression
    ABL1 gene sage expression
    About these images

    CGAP SAGE TAG: AGGTACTGGT

    SOURCE GeneReport for Unigene cluster: Hs.431048

    Expression variation in blood from EXPOLDB for ABL1

    UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519
    Tissue specificity: Widely expressed

    Primers: OriGene genome-wide validated SYBR primer pairs: ABL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ABL1: PPH00087A
        SABiosciences Expression via Pathway-Focused PCR Arrays including ABL1 (see all 8): PAHS-012A PAHS-020A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ABL1 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ABL11   -- c-abl oncogene 1, receptor tyrosine kinase 88.24(n)
    91.48(a)
    491292  XM_548413.2  XP_548413.2 
    chimpanzee
    (Pan troglodytes)
    ABL11   -- c-abl oncogene 1, receptor tyrosine kinase 99.54(n)
    99.91(a)
    464802  XM_001166213.1  XP_001166213.1 
    cow
    (Bos taurus)
    ABL11   -- c-abl oncogene 1, receptor tyrosine kinase 87.43(n)
    91.45(a)
    540876  XM_613548.3  XP_613548.2 
    rat
    (Rattus norvegicus)
    Abl11   -- c-abl oncogene 1, receptor tyrosine kinase 85.24(n)
    89.02(a)
    311860  XM_001067860.1  XP_001067860.1 
    mouse
    (Mus musculus)
    Abl11 , 5 2 (21.86 cM)5
    c-abl oncogene 1, non-receptor tyrosine kinase5
    c-abl oncogene 1, receptor tyrosine kinase1
    84.81(n)1
    88.38(a)1
    113501  NM_009594.21  NP_033724.11 
     AI3250925  AK0378875  (see all 41)
    About this table        Species with no ortholog for ABL1

    ENSEMBL Gene Tree for ABL1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ABL1 gene
    TEC2  BMX2  ABL22  SRMS2  ITK2  PTK62  TXK2  BTK2  

    ABL1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/2088 NCBI SNPs in ABL1 are shown (see all 2088)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs74571,2
    C,F,O,A,133762826(+) GTTAAC/TGTGAT 2 -- ut3119Minor allele frequency- T:0.30MN NS EA NA WA 1430
    rs97621,2
    C,F,A,H,133762553(+) TTCCCA/GCCCCT 2 -- ut31 ese39Minor allele frequency- G:0.35NS NA WA 198
    rs107531,2
    --133761923(+) GGCAGG/AGGACA 2 -- ut31 ese31Minor allele frequency- A:0.00MN 184
    rs119911,2
    C,F,A,133762558(+) ACCCCT/CTCATA 2 -- ut31 ese317Minor allele frequency- C:0.32MN NS EA NA WA 1104
    rs9137211,2
    C,A,133645683(+) gaagcT/Cgggag 1 -- int14Minor allele frequency- C:0.25NA WA 8
    rs9464861,2
    C,F,O,A,133646005(-) GCCAAG/ATAATT 1 -- int120Minor allele frequency- A:0.40NA NS EA WA 1204
    rs10561691,2
    C,133760677(+) TCCACC/TGCCTT 4 T ref1 syn1 ese35Minor allele frequency- T:0.01NS 190
    rs10561711,2
    C,F,H,133761001(+) GGTCCG/AGCGGC 4 /P ref1 syn1 ese319Minor allele frequency- A:0.26MN NS NA WA 1046
    rs10561741,2
    C133761139(+) TACCCG/ATGACA 2 -- ut31 ese35Minor allele frequency- A:0.01NS 190
    rs10562091,2
    C,F,O,133762590(+) GCACAG/AGCCCT 2 -- ut31 ese314Minor allele frequency- A:0.10MN NS EA NA WA 866
    About this table

    HapMap Linkage Disequilibrium images for ABL1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for ABL1
         7 CNVs: 3782 96316 83198 96318 7726 83199 96320
         6 Indels: 96319 96317 96321 29063 65533 83200

    QIAGEN SeqTarget long-range PCR primers for resequencing ABL1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ABL1 for disorders           About GeneDecksing

    OMIM: 189980

    UniProtKB/Swiss-Prot: ABL1_HUMAN, P00519

  • Note=A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia. Translocation
  • t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute
    lymphoblastic leukemia (ALL)

    10/55 Novoseek disease relationships for ABL1 gene (see all 55)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 91.9 112 18243808 (3), 2157692 (2), 16825513 (2), 7718887 (2) (see all 97)
    blast crisis 79.7 14 10822991 (2), 10190307 (2), 10498618 (2), 12759927 (2) (see all 7)
    leukemia 77.8 84 18257513 (3), 9341866 (3), 2163816 (2), 17959833 (2) (see all 67)
    lymphoblastic leukemia acute 70.4 12 8242587 (1), 8632666 (1), 11801308 (1), 15964830 (1) (see all 12)
    cml chronic phase 67.7 2 1736009 (1)
    myeloproliferative disorders 65.1 11 10490629 (2), 12767088 (1), 9490692 (1), 15616602 (1) (see all 8)
    minimal residual disease 62.2 1 16213363 (1)
    myeloproliferative neoplasm 59.2 4 18971950 (1), 19175693 (1)
    leukemogenesis 56.9 12 11387320 (2), 9790503 (1), 12887890 (1), 20082857 (1) (see all 7)
    gastrointestinal stromal tumor 54.4 4 15637141 (1), 15717993 (1), 15727903 (1), 18553235 (1)
    About this table

    3 PharmGKB disease relationships for ABL1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Diabetes Mellitus, Non-Insulin-DependentCO  PD  15758023
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    Leukemia, Myeloid, ChronicPD  GN  15243647
    About this table

    Genetic Association Database (GAD): ABL1
    Human Genome Epidemiology (HuGE) Navigator: ABL1 (15 documents)
    Tumor Gene Database (TGDB): ABL1

    Export disorders and mutations for ABL1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/1040 PubMed articles for ABL1 gene, integrated from 7 sources (see all 1040):
    (articles sorted by number of sources associating them with ABL1)
    1. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2, 7 Yoshida K.... Miki Y. (2005)
    2. Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. (PubMed id 7665185)1, 2, 7 Chissoe S.L.... Roe B.A. (1995)
    3. Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation. (PubMed id 16678104)1, 2, 7 Liu X....Cao C. (2006)
    4. Role of interfacial water molecules in proline-rich l igand recognition by the Src homology 3 domain of Abl. (PubMed id 19906645)1, 2, 7 Palencia A....Luque I. (2010)
    5. A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. (PubMed id 10194451)1, 2, 7 Wisniewski D.... Clarkson B. (1999)
    6. Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution. (PubMed id 1281542)1, 2, 7 Overduin M.... Cowburn D. (1992)
    7. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
    8. Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. (PubMed id 16543148)1, 2 Nagar B.... Kuriyan J. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. A single nucleotide polymorphism in the coding region of ABL and its effects on sensitivity to imatinib. (PubMed id 16151465)1, 4 Crossman L.C....Deininger M.W. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25 HGNC: 76 AceView: ABL1 Ensembl:ENSG00000097007 euGenes: HUgn25
    ECgene: ABL1 Kegg: 25 H-InvDB: ABL1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ABL1 Genetics and Cytogenetics in Oncology and Haematology
    CGP resequencing studieshttp://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ABL1
    NIEHS-SNPshttp://egp.gs.washington.edu/data/abl1/
    Wikipedia http://en.wikipedia.org/wiki/Abl_gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ABL1 gene:
    Search GeneIP for patents involving ABL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     Regulatory tfbs in ABL1 promoter
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