Aliases &
Descriptions
for BSPRY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| B-box and SPRY domain containing1 2 | | FLJ201501 2 | | B-box and SPRY-domain containing protein2 | | B box and SPRY domain-containing protein2 | | zetin 12 |
Export aliases for BSPRY gene to outside databasesPrevious GC identifers: GC09P107843 GC09P109565 GC09P111487 GC09P113191 GC09P115151 GC09P116111 |
Summaries
for BSPRY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity (By similarity)
|
Genomic Views
for BSPRY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BSPRY gene promoter:
GCNF-2 GCNF-1 Oct-B1 oct-B3 POU2F1 POU2F2 oct-B2 POU2F2 (Oct-2.1) POU2F2B POU2F2C
Other transcription factors
Search SABiosciences Chromatin IP Primers for BSPRY
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q33.1BSPRY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P085719: view genomic region
(about GC identifiers)
Start:
|
85,719,212 bp from pter |
End:
|
85,740,717 bp from pter |
Size:
|
21,506 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr9+ 116,111,821-116,133,513 |
RefSeq DNA sequence:- NC_000009.11 NT_008470.19
|
Proteins
for BSPRY gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4 (See
protein sequence)Recommended Name: B box and SPRY domain-containing protein Size: 402 amino acids; 44381 Da
Subunit: Interacts with TRPV5 and TRPV6. Interacts with YWHAZ/14-3-3 protein zeta (By similarity)
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=BAA90980.1; Type=Erroneous initiation;
Secondary accessions: B3KS19 Q96DJ2 Q9H4E4 Q9NXN0Alternative splicing: 2 isoforms: Q5W0U4-1 Q5W0U4-2 Explore the universe of human proteins at neXtProt for BSPRY: NX_Q5W0U4
REFSEQ proteins: NP_060158.2
ENSEMBL proteins: ENSP00000363298
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
BSPRY for ontologies About GeneDecksing
Antibodies for BSPRY:
Assays for BSPRY: |
Protein
Domains/
Families
for BSPRY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BSPRY for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5W0U4ProtoNet protein and cluster: Q5W0U4 3 Blocks protein families: IPB000315 B-box zinc finger signature IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4Similarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domain |
Gene Function
for BSPRY gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity (By similarity)
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
BSPRY for ontologies About GeneDecksing
|
Pathways & Interactions
for BSPRY gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for BSPRY
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BSPRY
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006816 | calcium ion transport |
IEA | -- |
About this table
BSPRY for ontologies About GeneDecksing
|
Drugs & Compounds
for BSPRY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for BSPRY
|
Transcripts
for BSPRY gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for BSPRY gene: NM_017688.2 Additional cDNA sequence: AJ276691.1 AK000157.1 AK092607.1 BC001477.2 CR603733.1 6 DOTS entries: DT.92451336 DT.92451339 DT.97839325 DT.100754196 DT.92042114 DT.91786817 24/104 AceView cDNA sequences (see all 104): AA569126 AW237259 AI207240 BF590829 AI279588 CA450456 CD676101 BP370567 BX106172 AI278908 AW204328 AI951830 AK092607 AA551900 AA829350 CR603733 AA639547 AL580969 AA860794 AA772358 AI804376 AA935729 AA724242 AA372012
 highest scoring ESTs for BSPRY:H81554 AA321659 AA341133 AA372012 AA502916 AA505859 AA551900 AA569126 AA621009 AA772358 Unigene Cluster for BSPRY: B-box and SPRY domain containing Hs.614517 [show with all ESTs]Unigene Representative Sequence: NM_017688
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374183(uc004bhg.3 uc010muw.2) ENST00000462085
|
Expression
for BSPRY gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| BSPRY expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching BSPRY gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 55827_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.96 |
1.01 |
W38021 |
0.80 |
1.00 |
0.91 |
1 |
| 48089_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.97 |
1.00 |
H81554 |
1.00 |
1.00 |
1.00 |
1 |
| 218792_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_017688 |
0.60 |
1.00 |
0.82 |
1 |
| 222746_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AJ276691 |
0.80 |
1.00 |
0.91 |
1 |
| 218792_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 222746_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
BSPRY for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCTCCAGGTA
SOURCE GeneReport for Unigene cluster: Hs.614517
SABiosciences Custom PCR Arrays for BSPRY
|
Orthologs
for BSPRY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BSPRY gene from 5/8 species (see all 8)
About this table Species with no ortholog for BSPRY
ENSEMBL Gene Tree for BSPRY (if available) |
Paralogs
for BSPRY gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for BSPRY gene
- TRIM142
BSPRY for paralogs About GeneDecksing
|
Genomic Variants
for BSPRY gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 9 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for BSPRY (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BSPRY
1 Indel: 59505 | | QIAGEN SeqTarget long-range PCR primers for resequencing BSPRY |
|
Disorders & Mutations
for BSPRY gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BSPRY for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: BSPRY (1 document)
Export disorders and mutations for BSPRY gene to outside databases
|
Medical News
for BSPRY gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for BSPRY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for BSPRY gene integrated from 7 sources:
(articles sorted by number of sources associating them with BSPRY)- BSPRY, a novel protein of the Ro-Ret family. (PubMed id 10978534)1, 2, 3 Schenker T. and Trueb B. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. (PubMed id 11099500)1, 3 Gisler S.M....Murer H. (2001)
- Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12). (PubMed id 19929093)1, 7 Machida J....Ono T. (2009)
- Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins. (PubMed id 12615066)1 Birkenfeld J....Roth D. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for BSPRY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BSPRY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BSPRY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BSPRY gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BSPRY gene:
Search GeneIP for patents involving BSPRY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BSPRY gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for BSPRY |
| |  |  |  |  | | | | |
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