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CLDN10 Gene

protein-coding GIFtS: 53

GC13P076683

claudin 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
claudin 10¹ ²
CPETRL3¹ ²
OSP-L¹ ²
OSP-like protein² ³
claudin-10²

External Ids:	HGNC: 2033¹	Entrez Gene: 9071²	Ensembl: ENSG00000134873⁷	UniProtKB: P78369³

Export aliases for CLDN10 gene to outside databases

Previous GC identifers: GC13P094445 GC13P090473 GC13P094922 GC13P093783 GC13P094883 GC13P096085

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLDN10:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight

junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely

through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in

maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of

primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been

reported, but the transcript sequences of some variants are not determined.

UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through

calcium-independent cell-adhesion activity (By similarity)

Gene Wiki entry for CLDN10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CLDN10 gene promoter:
         Chx10   NF-E2   NF-E2 p45   FOXF2   C/EBPbeta   SRF   TGIF   RP58   GATA-1   POU2F1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CLDN10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CLDN10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31-q34 Ensembl cytogenetic band: 13q32.1 HGNC cytogenetic band: 13q31-q34

CLDN10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLDN10 gene location

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P076683: view genomic region (about GC identifiers)

Start:	76,683,603 bp from pter
End:	76,829,764 bp from pter
Size:	146,162 bases
Orientation:	plus strand

1 alternative location:

Chr13+ 96,085,858-96,231,906

RefSeq DNA sequence:

NC_000013.10 NT_009952.14

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369 (See protein sequence)

Recommended Name: Claudin-10

Size: 228 amino acids; 24488 Da

Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for CLDN10: NX_P78369

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001153572.1 NP_008915.1 NP_878268.1

ENSEMBL proteins:

ENSP00000366051 ENSP00000299339 ENSP00000366069

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CLDN10
	GenScript Custom Purified and Recombinant Proteins Services for CLDN10
	Novus Biologicals Protein for CLDN10
	Novus Biologicals Lysate for CLDN10
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005923	tight junction	ISS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IEA	--

About this table

CLDN10 for ontologies About GeneDecksing

Antibodies for CLDN10:

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	Novus Biologicals Antibodies for CLDN10
	Browse antibodies at Epitomics

Assays for CLDN10:

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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CLDN10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CLDN10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CLDN10 for domains About GeneDecksing

4 InterPro domains/families:

IPR017974 Claudin_CS

IPR003554 Claudin10

IPR006187 Claudin

IPR004031 PMP22/EMP/MP20/Claudin

Graphical View of Domain Structure for InterPro Entry P78369

ProtoNet protein and cluster: P78369

2 Blocks protein families:

IPB003554 Claudin-10 signature

IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369

Similarity: Belongs to the claudin family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CLD10_HUMAN, P78369

Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through

calcium-independent cell-adhesion activity (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CLDN10 Sigma-Aldrich shRNA Panels and shRNA for CLDN10
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CLDN10 OriGene shRNA RFP (see all 3): CLDN10 OriGene basic RS shRNA (see all 3): CLDN10 OriGene siRNA (see all 3): CLDN10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CLDN10

miRNA:		Sigma-Aldrich microRNA Mimics for CLDN10 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CLDN10
		3 SABiosciences Assays for microRNAs that regulate CLDN10:
		hsa-miR-495 hsa-miR-410 hsa-miR-486-5p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CLDN10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CLDN10 OriGene untagged cDNA clones in CMV expression vector (see all 2): CLDN10 OriGene 3'-UTR clone (see all 3): CLDN10 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CLDN10
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CLDN10

Genatlas biochemistry entry for CLDN10:

claudin 10,clostridium perfringens enterotoxin receptor,integral membrane protein,claudin family of major structural

components of tight junction (TJ) strands,widely expressed

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0042802	identical protein binding	ISS	--

About this table

CLDN10 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CLDN10 for pathways About GeneDecksing

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CLDN10

	Tight Junction Signaling
	Leukocyte Extravasation Signaling

4 Kegg Pathways (Kegg details for CLDN10):

	hsa04514 Cell adhesion molecules (CAMs)
	hsa04530 Tight junction
	hsa04670 Leukocyte transendothelial migration
	hsa05160 Hepatitis C

SABiosciences Custom Pathway-Focused PCR Arrays for CLDN10

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CLDN10

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CLDN10

5/105 Interacting proteins for CLDN10 (ENSP00000299339³) via UniProtKB, MINT, and/or STRING (see all 105)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTNNB1	ENSP00000344456³	STRING: ENSP00000344456
ABCB1	ENSP00000265724³	STRING: ENSP00000265724
ACOX1	ENSP00000301608³	STRING: ENSP00000301608
ALDH3A1	ENSP00000334590³	STRING: ENSP00000334590
APBB1	ENSP00000299402³	STRING: ENSP00000299402

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	10508613
GO:0016338	calcium-independent cell-cell adhesion	ISS	--

About this table

CLDN10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CLDN10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CLDN10 Sigma-Aldrich shRNA Panels and shRNA for CLDN10
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CLDN10 OriGene shRNA RFP (see all 3): CLDN10 OriGene basic RS shRNA (see all 3): CLDN10 OriGene siRNA (see all 3): CLDN10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CLDN10

miRNA:		Sigma-Aldrich microRNA Mimics for CLDN10 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CLDN10
		3 SABiosciences Assays for microRNAs that regulate CLDN10:
		hsa-miR-495 hsa-miR-410 hsa-miR-486-5p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CLDN10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CLDN10 OriGene untagged cDNA clones in CMV expression vector (see all 2): CLDN10 OriGene 3'-UTR Clone (see all 3): CLDN10 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CLDN10

Primers:		OriGene genome-wide validated SYBR primer pairs: CLDN10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CLDN10: PPH08650A

REFSEQ mRNAs for CLDN10 gene (3 alternative transcripts):

NM_001160100.1 NM_006984.4 NM_182848.3

Additional cDNA sequence:

AF339794.1 AK055855.1 AK315737.1 BC010920.1 CR456845.1 U89916.1

7 DOTS entries:

DT.212544 DT.75199458 DT.92421647 DT.40118535 DT.92421648 DT.311780 DT.95070448

24/91 AceView cDNA sequences (see all 91):

AK055855 NM_006984 AI089846 BU686852 CB119421 AW160992 CA450135 AA341006

AA394111 AF339794 AI861881 AW960040 CA335155 BC010920 NM_182848 BG429316

AI522187 AL699037 CA776387 BI523494 BM955857 U89916 AW452851 CF529753

highest scoring ESTs for CLDN10:

U89916 AA142937 AA292311 AA366287 AA394111 AA480851 AA902570 AF339794 AI089846 AI095035

Unigene Cluster for CLDN10:

Claudin 10

Hs.534377 [show with all ESTs]

Unigene Representative Sequence: NM_182848

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376855 ENST00000299339 ENST00000376873(uc001vmg.2 uc010tii.1 uc001vmh.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CLDN10 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching CLDN10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39579_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U89916	1.00	1.00	1.00	1
42072_at²^{, 3}	U95-B	1	0.31	1.00	0.57	0.39	AI861881	0.60	1.00	0.82	1
205328_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006984	0.60	1.00	0.82	1
205328_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1556687_a_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

About this table

CLDN10 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CLDN10 gene electronic northern expression

About these images

CGAP SAGE TAG: GTGGAGAAGA

SOURCE GeneReport for Unigene cluster: Hs.534377

Expression variation in blood from EXPOLDB for CLDN10

Primers:		OriGene genome-wide validated SYBR primer pairs: CLDN10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CLDN10: PPH08650A

SABiosciences Custom PCR Arrays for CLDN10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CLDN10 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CLDN10¹	--	claudin 10	93.86(n) 96.93(a)	476963 XM_534163.2 XP_534163.1
chimpanzee (Pan troglodytes)	CLDN10¹	--	claudin 10	99.42(n) 100(a)	452626 XM_509702.2 XP_509702.1
cow (Bos taurus)	CLDN10¹	--	claudin 10	92.54(n) 96.93(a)	506545 NM_001014857.1 NP_001014857.1
rat (Rattus norvegicus)	Cldn10¹	--	claudin 10	88.6(n) 95.61(a)	290485 XM_214250.4 XP_214250.4
mouse (Mus musculus)	Cldn10^{1 , 5}	14 (62.55 cM)⁵	claudin 10^{1, 5}	88.16(n)¹ 93.86(a)¹	58187¹ NM_021386.3¹ NP_067361.1¹ AF124425⁵ AI851016⁵ (see all 14)

About this table Species with no ortholog for CLDN10

ENSEMBL Gene Tree for CLDN10 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CLDN10 gene

CLDN20² CLDN24² CLDN18² CLDN2² CLDN25² CLDN15² CLDN14² CLDN22²

CLDN10 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs16880^1,2	C,F,H,	96161737(-)	`GGTACT/AGCTGC`	2	--	int¹		10	NA EA NS	746
rs723575^1,2	C,F,A,H,	96203840(+)	`TTTCTG/ACCTAA`	3	--	int¹ ng5¹		17	NA EA NS WA	2158
rs723576^1,2	C,F,A,	96204091(+)	`ATGAAG/AGAATG`	3	--	ng5¹ int¹		35	NA EA NS WA	3630
rs869529^1,2		96129943(-)	`ATCCAC/GAGTAG`	2	--	int¹		4	NS EA	418
rs869530^1,2		96129937(-)	`AGTAGG/AGTTGG`	2	--	int¹		4	NS EA	412
rs869531^1,2	C,F,A,	96129717(-)	`ccgggT/Ggatat`	2	--	int¹		2	NA EA	160
rs870706^1,2	F,A,	96126790(+)	`CAGAGC/TGGAGA`	2	--	int¹		4	NS EA	420
rs870707^1,2	C,F,O,A,	96126828(+)	`AAGAAC/AAGGTT`	2	--	int¹		22	NS EA NA	1928
rs877960^1,2	C,A,	96133534(+)	`AGTGCA/GGACCT`	2	--	int¹		6	NA EA WA	168
rs877961^1,2	C,A,	96133557(+)	`GGGGAG/AGGGCA`	2	--	int¹ trp³		6	NA EA WA	168

About this table

HapMap Linkage Disequilibrium images for CLDN10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CLDN10: --

QIAGEN SeqTarget long-range PCR primers for resequencing CLDN10

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CLDN10 for disorders About GeneDecksing

1 Novoseek disease relationship for CLDN10 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	30.6	18	18025272 (7), 17390062 (2), 15701840 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: CLDN10 (2 documents)

Export disorders and mutations for CLDN10 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/33 PubMed articles for CLDN10 gene, integrated from 7 sources (see all 33):
(articles sorted by number of sources associating them with CLDN10)

Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. (PubMed id 18025272)^{1, 3, 7} Ip Y.C....Fan S.T. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma. (PubMed id 15701840)^{1, 7} Cheung S.T....So S. (2005)
Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. (PubMed id 19383724)^{1, 7} GA1nzel D....MA1ller D. (2009)
Claudins in human cancer: a review. (PubMed id 19924644)¹ Ouban A. and Ahmed A.A. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The claudins. (PubMed id 19706201)¹ Lal-Nag M. and Morin P.J. (2009)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)² Imami K.... Ishihama Y. (2008)
Structure and function of claudins. (PubMed id 18036336)¹ Krause G....Blasig I.E. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9071	HGNC: 2033	AceView: CLDN10	Ensembl:ENSG00000134873	euGenes: HUgn9071
ECgene: CLDN10	Kegg: 9071	H-InvDB: CLDN10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for CLDN10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for CLDN10 gene:
Search GeneIP for patents involving CLDN10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CLDN10		Antibodies for CLDN10
	Super-pooled esiRNAs for CLDN10		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CLDN10		microRNA Mimics for CLDN10
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for CLDN10 (Claudin-10)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
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	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CLDN10
	SeqTarget long-range PCR primers for resequencing CLDN10
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CLDN10
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CLDN10

	GenScript Custom Purified and Recombinant Proteins Services for CLDN10		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CLDN10
	GenScript Custom Assay Services for CLDN10		GenScript Custom Superior Antibodies Services for CLDN10
	GenScript Custom overexpressing Cell Line Services for CLDN10		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in CLDN10 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ELISAs and CLIAs for CLDN10

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

CLDN10 gene at Home site.

hostname: genecards db genecards_305 index build: 81e solr: 1.4

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CLDN10 Gene

protein-coding GIFtS: 53

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Export list of displayed genes

CLDN10 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor CLDN10 gene

Summariesfor CLDN10 gene

Genomic Viewsfor CLDN10 gene

Proteinsfor CLDN10 gene

Protein Domains/Familiesfor CLDN10 gene

Gene Functionfor CLDN10 gene

Pathways & Interactionsfor CLDN10 gene

Drugs & Compoundsfor CLDN10 gene

Transcriptsfor CLDN10 gene

Expression for CLDN10 gene

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Disorders & Mutationsfor CLDN10 gene

Medical Newsfor CLDN10 gene

Publicationsfor CLDN10 gene

External Searches for CLDN10 gene

Genome Databases showing CLDN10 gene

Other Databases showing CLDN10 gene

Specialized Databases showing CLDN10 gene

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Aliases &
Descriptions
for CLDN10 gene

Summaries
for CLDN10 gene

Genomic Views
for CLDN10 gene

Proteins
for CLDN10 gene

Protein Domains/
Families
for CLDN10 gene

Gene Function
for CLDN10 gene

Pathways & Interactions
for CLDN10 gene

Drugs & Compounds
for CLDN10 gene

Transcripts
for CLDN10 gene

Expression
for CLDN10 gene

Orthologs
for CLDN10 gene

Paralogs
for CLDN10 gene

Genomic Variants
for CLDN10 gene

Disorders & Mutations
for CLDN10 gene

Medical News
for CLDN10 gene

Publications
for CLDN10 gene

Intellectual Property
for CLDN10 gene

Products
for CLDN10 gene