Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



HK1 Gene

protein-coding   GIFtS: 64

GC10P065029
hexokinase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
hexokinase 11 2     HK1-tc2
Brain form hexokinase2 3     glycolytic enzyme2
Hexokinase type I2 3     hexokinase-12
HK I2 3     HK1-ta2
HK1-tb2     HXK12
HKI2     EC 2.7.1.13

External Ids:    HGNC: 49221   Entrez Gene: 30982   Ensembl: ENSG000001565157   UniProtKB: P193673   

Export aliases for HK1 gene to outside databases

Previous GC identifers: GC10P069840 GC10P070116 GC10P070922 GC10P070374 GC10P070699 GC10P071031


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HK1:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways.
This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in
this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene
results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform
has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript
variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.
(provided by RefSeq)

summary for HK1:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for HK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HK1 gene promoter:
         Max1   c-Myc   HNF-4alpha2   COUP-TF1   Max   RORalpha1   LCR-F1   XBP-1   Arnt   FAC1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for HK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HK1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22

HK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HK1 gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P065029:  view genomic region     (about GC identifiers)

Start:
65,029,590 bp from pter
End:
65,161,554 bp from pter
Size:
131,965 bases
Orientation:
plus strand

1 alternative location:
Chr10+ 71,029,740-71,161,638     
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: HXK1_HUMAN, P19367 (See protein sequence)
Recommended Name: Hexokinase-1  
Size: 917 amino acids; 102486 Da
Subunit: Monomer
Subcellular location: Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in
membrane binding
Miscellaneous: In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III
and IV (glucokinase)
PDB structures from and Proteopedia :
1CZA (3D)    1DGK (3D)    1HKB (3D)    1HKC (3D)    1QHA (3D)    
Secondary accessions: O43443 O43444 O75574 Q5VTC3 Q96HC8 Q9NNZ4 Q9NNZ5
Alternative splicing: 4 isoforms:  P19367-1   P19367-2   P19367-3   P19367-4   

Explore the universe of human proteins at neXtProt for HK1: NX_P19367 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (5 alternative transcripts): 
    NP_000179.2  NP_277031.1  NP_277032.1  NP_277033.1  NP_277035.2  


    ENSEMBL proteins: 
    ENSP00000398316 ENSP00000353433 ENSP00000385930 ENSP00000348697 ENSP00000409761 ENSP00000415949 
    ENSP00000389702 ENSP00000408774 ENSP00000384774 ENSP00000298649 ENSP00000402103 ENSP00000352398 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HK1
    GenScript Custom Purified and Recombinant Proteins Services for HK1 
    Novus Biologicals Proteins for HK1
    Novus Biologicals Lysates for HK1
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HK1

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005730NOT nucleolus IDA18029348
    GO:0005739 mitochondrion IDA18029348
    GO:0005741 mitochondrial outer membrane IEA--
    GO:0005829 cytosol TAS--
    About this table

    HK1 for ontologies           About GeneDecksing



    Antibodies for HK1: 
    Millipore Mono- and Polyclonal Antibodies for the study of HK1
    Sigma-Aldrich Antibodies for HK1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HK1  (Hexokinase I)
    Browse OriGene Antibodies
    GenScript Superior Antibodies for HK1 
    Novus Biologicals Antibodies for HK1
    Epitomics antibodies for HK1

    Assays for HK1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HK1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HK1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HK1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019807 Hexokinase_CS
     IPR001312 Hexokinase
     IPR022672 Hexokinase_N
     IPR022673 Hexokinase_C

    Graphical View of Domain Structure for InterPro Entry P19367

    ProtoNet protein and cluster: P19367

    1 Blocks protein family: IPB001312 Hexokinase

    UniProtKB/Swiss-Prot: HXK1_HUMAN, P19367
    Domain: The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic
    activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain
    can bind a single glucose and Gluc-6-P molecule
    Similarity: Belongs to the hexokinase family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: HXK1_HUMAN, P19367
    Catalytic activity: ATP + D-hexose = ADP + D-hexose 6-phosphate
    Enzyme regulation: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P
    Enzyme Number (IUBMB): EC 2.7.1.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for HK1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for HK1
    Sigma-Aldrich shRNA Panels and shRNA for HK1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): HK1
    OriGene shRNA RFP (see all 5): HK1
    OriGene basic RS shRNA (see all 5): HK1
    OriGene siRNA (see all 5): HK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HK1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HK1 
    2 SABiosciences Assays for microRNAs that regulate HK1:
    hsa-miR-138 hsa-miR-1207-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): HK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): HK1
    OriGene untagged cDNA clones in CMV expression vector (see all 5): HK1
    OriGene 3'-UTR clone (see all 5): HK1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HK1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for HK1 

    Genatlas biochemistry entry for HK1:
    hexokinase 1,108kDa,glycolysis and gluconeogenesis,energy pathway,red blood specific with two isoforms HK1,universally
    expressed,and an erythroid specific isoform AXR derived from the HK1 gene by the alternate use of a specific promoter
    and an alternative splicing

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004340 glucokinase activity TAS--
    GO:0004396 hexokinase activity TAS3207429
    GO:0005524 ATP binding IEA--
    GO:0016301 kinase activity IEA--
    About this table

    HK1 for ontologies           About GeneDecksing

    Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hk1):

    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemliver/biliary system
    renal/urinary systemreproductive systemskin/coat/nails

    HK1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    HK1 for pathways           About GeneDecksing

    3 Millipore Pathways for HK1
        Glycogen metabolism
    Glycolysis and gluconeogenesis (short map)
    Galactose metabolism

    5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  HK1
        Glycolysis/Gluconeogenesis
    Galactose Metabolism
    Fructose and Mannose Metabolism
    Starch and Sucrose Metabolism
    Aminosugars Metabolism

    5/11 Kegg Pathways  (Kegg details for HK1) (see all 11):
        hsa00010 Glycolysis / Gluconeogenesis
    hsa00051 Fructose and mannose metabolism
    hsa00052 Galactose metabolism
    hsa00500 Starch and sucrose metabolism
    hsa00520 Amino sugar and nucleotide sugar metabolism

    UniProtKB/Swiss-Prot: HXK1_HUMAN, P19367
    Pathway: Carbohydrate metabolism; hexose metabolism

        SABiosciences Custom Pathway-Focused PCR Arrays for HK1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HK1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HK1

    5/285 Interacting proteins for HK1 (ENSP000003486973 P193672) via UniProtKB, MINT, and/or STRING (see all 285)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ACAD9Q9H8452MINT-8079030
    ACADVLP497482MINT-8079030
    ACOT9Q9Y3052MINT-8079030
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975 carbohydrate metabolic process TAS--
    GO:0006096 glycolysis IEA--
    GO:0008645 hexose transport TAS--
    GO:0015758 glucose transport TAS--
    GO:0055085 transmembrane transport TAS--
    About this table

    HK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    HK1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HK1 available from Tocris Bioscience
    CompoundAction CAS number
    LonidamineMitochondrial hexokinase inhibitor[50264-69-2]
    About this table


    10/22 Novoseek chemical compound relationships for HK1 gene (see all 22)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 6-phosphate 82.7 53 16166083 (7), 10531306 (5), 17949503 (4), 9493266 (3) (see all 19)
    glucose 68.5 82 12690200 (3), 9493266 (3), 8446591 (2), 9735292 (2) (see all 38)
    glycogen 52.8 15 18165236 (3), 8798601 (3), 10438462 (1), 9486162 (1)
    atp 51.7 17 9422720 (3), 10574795 (2), 8855953 (2), 8215417 (1) (see all 9)
    18f fluorodeoxyglucose 48.1 8 15509640 (4), 18695903 (2)
    mgatp 47.3 2 15724432 (1)
    digitonin 46.5 1 7683206 (1)
    pyruvate 42.5 4 10438462 (1), 9215806 (1), 9166680 (1)
    2-deoxyglucose 37.6 1 16555088 (1)
    dextran 31 3 7683206 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for HK1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for HK1
    Sigma-Aldrich shRNA Panels and shRNA for HK1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): HK1
    OriGene shRNA RFP (see all 5): HK1
    OriGene basic RS shRNA (see all 5): HK1
    OriGene siRNA (see all 5): HK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HK1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HK1 
    2 SABiosciences Assays for microRNAs that regulate HK1:
    hsa-miR-138 hsa-miR-1207-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): HK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): HK1
    OriGene untagged cDNA clones in CMV expression vector (see all 5): HK1
    OriGene 3'-UTR Clone (see all 5): HK1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for HK1 
    Primers: OriGene genome-wide validated SYBR primer pairs: HK1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HK1: PPH02045A

    REFSEQ mRNAs for HK1 gene (5 alternative transcripts): 

    NM_000188.2  NM_033496.2  NM_033497.2  NM_033498.2  NM_033500.2  

    Additional cDNA sequence: 

    AB209526.1 AF073786.2 AK091267.1 AK128226.1 AK292012.1 AK294428.1 AK309904.1 BC008730.2 
    BC128210.1 CR598171.1 CR601325.1 CR605003.1 CR608450.1 M75126.1 U38226.1 U38227.1 
    U38228.1 X66957.1 

    20 DOTS entries:

    DT.100663278  DT.452205  DT.100030671  DT.100663271  DT.100663265  DT.91762069  DT.97779307  DT.99995823 
    DT.100707784  DT.91762076  DT.100030669  DT.97820459  DT.95373800  DT.95373803  DT.85104252  DT.91762074 
    DT.91762077  DT.95373795  DT.95373797  DT.97806338 

    24/553 AceView cDNA sequences (see all 553):

    BI493693 AF073786 BG057140 CR598171 NM_033500 AW189147 BM557800 CB850795 
    BI861726 AW515702 CD672092 CD515718 NM_033497 AI754494 BM826385 BU732947 
    AA357507 BU675197 BQ946206 BM853722 BU191098 AA300273 AI539513 BQ921622 

    highest scoring ESTs for HK1:

    AA084325 AA215528 AA309185 AA310839 AA316819 AA357507 AA363923 AA364575 AA365258 AA367458 

    Unigene Cluster for HK1:

    Hexokinase 1
    Hs.370365  [show with all ESTs]
    Unigene Representative Sequence: AK128226


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HK1 (see all 6)

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:              -     -                             -     -     -     -     -                                                                                 
    SP2:                                                                          -                                                                                 
    SP3:        -                             -           -                                                                                                         
    SP4:                                                                    -     -                                                                                 
    SP5:                                      -                                                                                                                     

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              

    About this scheme

    ECgene alternative splicing isoforms for HK1
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000421088 ENST00000476368 ENST00000483077 ENST00000480047(uc009xqc.1)
    ENST00000360289(uc001jpg.3 uc001jph.3 uc001jpi.3 uc001jpj.3)
    ENST00000405407 ENST00000470050 ENST00000464803 ENST00000483054 ENST00000493591
    ENST00000356342 ENST00000450646 ENST00000436817 ENST00000439900 ENST00000450557
    ENST00000404387 ENST00000298649(uc001jpk.3) ENST00000448642

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    HK1 expression in normal and diseased human tissues

    1  / 2  / 3

    2 probe-sets matching HK1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    200697_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000188 0.60 1.00 0.82 1
    200697_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    HK1 gene expression
    HK1 gene electronic northern expression
    HK1 gene sage expression
    About these images

    CGAP SAGE TAG: GTTTGATTTT

    SOURCE GeneReport for Unigene cluster: Hs.370365

    UniProtKB/Swiss-Prot: HXK1_HUMAN, P19367
    Tissue specificity: Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific

    Primers: OriGene genome-wide validated SYBR primer pairs: HK1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for HK1: PPH02045A
        SABiosciences Custom PCR Arrays for HK1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for HK1 gene from 5/19 species (see all 19)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    HK11   -- hexokinase 1 90.37(n)
    95.42(a)
    479234  XM_536376.2  XP_536376.2 
    chimpanzee
    (Pan troglodytes)
    HK11   -- hexokinase 1 98.75(n)
    98.35(a)
    450505  XM_001169069.1  XP_001169069.1 
    cow
    (Bos taurus)
    HK11   -- hexokinase 1 89.31(n)
    94.98(a)
    280817  NM_001012668.1  NP_001012686.1 
    mouse
    (Mus musculus)
    Hk11 , 5 10 (32.37 cM)5
    hexokinase 11, 5 86.56(n)1
    92.32(a)1
    152751  NM_010438.21  NP_034568.11 
     AA0034175  AK1436305  (see all 37)
    chicken
    (Gallus gallus)
    HK11   -- hexokinase 1 79.2(n)
    87.83(a)
    373889  NM_204101.1  NP_989432.1 
    About this table        Species with no ortholog for HK1

    ENSEMBL Gene Tree for HK1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for HK1 gene
    HK32  HKDC12  HK22  GCK2  

    HK1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1721 NCBI SNPs in HK1 are shown (see all 1721)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs122161,2
    C,F,A,71161281(+) CTCCCT/CGTGTG 4 -- ut31 ese3 trp37Minor allele frequency- C:0.11MN NS EA WA 650
    rs127511,2
    C,F,71160971(+) GTTGCG/TCTGGG 4 -- ut31 ese33Minor allele frequency- T:0.07MN WA 236
    rs131391,2
    C,F,71160897(+) GAGTCC/TGGGAT 4 -- ut3113Minor allele frequency- T:0.06MN NS EA NA WA 1208
    rs140061,2
    C,F,71160828(+) GGCAGC/TGGCAA 8 S ref1 syn1 ese32Minor allele frequency- T:0.11NA WA 78
    rs143821,2
    --71161220(+) TGGAAA/TATCAC 4 -- ut311Minor allele frequency- T:0.00MN 184
    rs7482351,2
    C,F,O,A,H,71142420(+) ACCAAA/GGACAT 8 K syn1 ref125Minor allele frequency- N:0.00MN NS EA NA WA 2950
    rs7491051,2
    C,F,A,71144702(+) TGATCA/GGGCAG 4 -- int119Minor allele frequency- G:0.34NA EA NS WA 1294
    rs7491061,2
    C,F,O,71144777(+) CTAGAT/GGACAG 4 -- int116Minor allele frequency- G:0.14NA EA NS WA 1294
    rs7491071,2
    C,F,A,H,71144813(+) GCTTTA/GTTTCA 4 -- int119Minor allele frequency- G:0.22NA EA NS 1488
    rs7491081,2
    C,F,O,A,71144869(+) GAAAGT/CGTCAC 4 -- int123Minor allele frequency- C:0.39NA EA NS WA 1450
    About this table

    HapMap Linkage Disequilibrium images for HK1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for HK1
         3 CNVs: 85360 2877 85359
         2 Indels: 85361 75302

    QIAGEN SeqTarget long-range PCR primers for resequencing HK1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HK1 for disorders           About GeneDecksing

    OMIM: 142600   disorders: 235700  

    UniProtKB/Swiss-Prot: HXK1_HUMAN, P19367

  • Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:235700]. HK deficiency is a rare
  • autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature

    7 Novoseek disease relationships for HK1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 19.6 5 18695903 (2), 10912295 (1), 8826847 (1), 7622299 (1)
    primary tumor 17.6 11 15509640 (3), 19235753 (2)
    tumors 12.1 21 19235753 (4), 19049977 (2), 18632830 (1), 16555088 (1)
    cancer 8.36 1 19689405 (1)
    metastasis 3.51 4 16841142 (1), 15509640 (1), 19235753 (1)
    breast cancer 0 1 15127240 (1)
    anemia 0 1 19651813 (1)
    About this table

    Genatlas disease: HK1
    hemolytic anemia including type I with a reduced activity of HK1,found in RBC,lymphocytes,platelets,fibroblats,type II
    with a decreased activity restricted to RBC

    Human Gene Mutation Database (HGMD): HK1
    Human Genome Epidemiology (HuGE) Navigator: HK1 (28 documents)

    Export disorders and mutations for HK1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/162 PubMed articles for HK1 gene, integrated from 7 sources (see all 162):
    (articles sorted by number of sources associating them with HK1)
    1. Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA. (PubMed id 10978502)1, 2, 7 Andreoni F.... Magnani M. (2000)
    2. Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control. (PubMed id 10574795)1, 2, 7 Rosano C.... Bolognesi M. (1999)
    3. Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate. (PubMed id 9735292)1, 2, 7 Aleshin A.E.... Honzatko R.B. (1998)
    4. The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate. (PubMed id 9493266)1, 2, 7 Aleshin A.E....Honzatko R.B. (1998)
    5. Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. (PubMed id 10686099)1, 2, 7 Aleshin A.E.... Honzatko R.B. (2000)
    6. Identification of the cDNA for human red blood cell-specific hexokinase isozyme. (PubMed id 9028305)1, 2, 7 Murakami K. and Piomelli S. (1997)
    7. Human hexokinase type I microheterogeneity is due to different amino- terminal sequences. (PubMed id 1985912)1, 2, 7 Magnani M.... Stocchi V. (1991)
    8. Crystallization and preliminary X-ray analysis of human brain hexokinase. (PubMed id 8706938)1, 2, 7 Aleshin A.E.... Honatko R.B. (1996)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3098 HGNC: 4922 AceView: HK1 Ensembl:ENSG00000156515 euGenes: HUgn3098
    ECgene: HK1 Kegg: 3098 H-InvDB: HK1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Hexokinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for HK1 gene:
    Search GeneIP for patents involving HK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for HK1 Antibodies for HK1
     Super-pooled esiRNAs for HK1 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HK1 Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Nano Scale siRNA for HK1
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HK1
     SeqTarget long-range PCR primers for resequencing HK1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HK1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HK1
     GenScript Custom Purified and Recombinant Proteins Services for HK1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HK1
     GenScript Custom Assay Services for HK1 GenScript Superior Antibodies for HK1
     GenScript Custom overexpressing Cell Line Services for HK1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for HK1 
    (Hexokinase I)

     Regulatory tfbs in HK1 promoter
     Search Chromatin IP Primers for HK1
     RT2 qPCR Primer Assay for HK1
     GNC Network for HK1
     Assays for microRNAs that regulate HK1
     SABiosciences Custom PCR Arrays for HK1
     Tocris compounds for HK1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for HK1
     Proteins for HK1
     Lysates for HK1
     Antibodies for HK1
     Recombinant Protein for HK1

     ELISAs and CLIAs for HK1
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    HK1 gene at Home site.
    hostname: genecards db genecards_305 index build: 81e solr: 1.4