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HSPA9 Gene

protein-coding GIFtS: 64

GC05M133080

heat shock 70kDa protein 9 (mortalin)
(Previous name: heat shock 70kDa protein 9B (mortalin-2) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HSPA9B)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
heat shock 70kDa protein 9 (mortalin)¹ ²		mthsp75¹
GRP75¹ ² ³ ⁵		heat shock 70kDa protein 9B (mortalin-2)¹
PBP74¹ ² ³		MGC4500²
HSPA9B² ³ ⁵		MTHSP75²
Heat shock 70 kDa protein 9² ³		heat shock 70kD protein 9B²
Peptide-binding protein 74² ³		mortalin, perinuclear²
75 kDa glucose-regulated protein² ³		mortalin-2²
MOT² ³		CSA²
GRP-75² ³		stress-70 protein, mitochondrial²
MOT2² ⁵		p66-mortalin²
mot-2¹		Mortalin³

External Ids:	HGNC: 5244¹	Entrez Gene: 3313²	Ensembl: ENSG00000113013⁷	UniProtKB: P38646³

Export aliases for HSPA9 gene to outside databases

Previous GC identifers: GC05M137920 GC05M137923

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA9:

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the

mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is

a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the

mitochondria. A pseudogene of this gene is found on chromosome 2.

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646

Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone

Gene Wiki entry for HSPA9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for HSPA9
Other transcription factors

Search SABiosciences Chromatin IP Primers for HSPA9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HSPA9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.1

HSPA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA9 gene location

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M133080: view genomic region (about GC identifiers)

Start:	133,080,998 bp from pter
End:	133,101,775 bp from pter
Size:	20,778 bases
Orientation:	minus strand

1 alternative location:

Chr5- 137,890,571-137,911,133

RefSeq DNA sequence:

NC_000005.9 NT_034772.6

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646 (See protein sequence)

Recommended Name: Stress-70 protein, mitochondrial precursor

Size: 679 amino acids; 73680 Da

Subunit: Interacts with FXN

Subcellular location: Mitochondrion

PDB structures from and Proteopedia :

3N8E (3D)

Secondary accessions: B2RCM1 P30036 P31932 Q1HB43 Q53H23 Q6GU03 Q9BWB7 Q9UC56

Explore the universe of human proteins at neXtProt for HSPA9: NX_P38646

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004125.3

ENSEMBL proteins:

ENSP00000297185 ENSP00000421892 ENSP00000429475 ENSP00000421311 ENSP00000423759 ENSP00000420944

ENSP00000425598 ENSP00000423098

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for HSPA9
	OriGene Purified Protein: HSPA9 OriGene Protein Over-expression Lysate: HSPA9
	GenScript Custom Purified and Recombinant Proteins Services for HSPA9
	Novus Biologicals Proteins for HSPA9
	Novus Biologicals Lysates for HSPA9
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HSPA9

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	7684501
GO:0005739	mitochondrion	TAS	16130169
GO:0009986	cell surface	IDA	12493773
GO:0042645	mitochondrial nucleoid	IDA	18063578

About this table

HSPA9 for ontologies About GeneDecksing

Antibodies for HSPA9:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for HSPA9
	R&D Systems Antibodies for HSPA9 (GRP75/HSPA9B)
	OriGene Antibodies (see all 3): HSPA9
	GenScript Custom Superior Antibodies Services for HSPA9
	Novus Biologicals Antibodies for HSPA9
	Epitomics antibodies for HSPA9

Assays for HSPA9:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HSPA9
	Enzo Life Sciences assays for HSPA9
	Uscn ELISAs and CLIAs for HSPA9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPA9 for domains About GeneDecksing

4 InterPro domains/families:

IPR018181 Heat_shock_70_CS

IPR001023 Hsp70

IPR012725 Chaperone_DnaK

IPR013126 Hsp_70

Graphical View of Domain Structure for InterPro Entry P38646

ProtoNet protein and cluster: P38646

1 Blocks protein family: IPB001023 Heat shock protein Hsp70

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646

Similarity: Belongs to the heat shock protein 70 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646

Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for HSPA9 Sigma-Aldrich shRNA Panels and shRNA for HSPA9
		OriGene 29mer shRNA kits in GFP-retroviral vector: HSPA9 OriGene shRNA RFP: HSPA9 OriGene basic RS shRNA: HSPA9 OriGene siRNA: HSPA9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HSPA9

miRNA:		Sigma-Aldrich microRNA Mimics for HSPA9 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HSPA9
		2 SABiosciences Assays for microRNAs that regulate HSPA9:
		hsa-miR-767-3p hsa-miR-532-5p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: HSPA9 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HSPA9 OriGene untagged cDNA clones in CMV expression vector: HSPA9 OriGene 3'-UTR clone: HSPA9 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for HSPA9
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for HSPA9

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0019899	enzyme binding	IEA	--
GO:0051082	unfolded protein binding	TAS	16130169

About this table

HSPA9 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

HSPA9 for pathways About GeneDecksing

3 Millipore Pathways for HSPA9

	Development Glucocorticoid receptor signaling
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for HSPA9

	Huntington's Disease Signaling
	Glucocorticoid Receptor Signaling

1 Kegg Pathway (Kegg details for HSPA9):

hsa03018 RNA degradation

SABiosciences Pathway-Focused PCR Arrays including HSPA9 (see all 4): PAHS-076A PAHS-3012A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HSPA9

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPA9

5/303 Interacting proteins for HSPA9 (ENSP00000297185³ P38646^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 303)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637²	STRING: ENSP00000269305 MINT-7557611 MINT-7557644 MINT-7557580 MINT-4302632
COBRA1	Q8WX92¹	EBI-354932,EBI-347721
C1QBP	Q07021²	MINT-6489217 MINT-8079030
HSPD1	P10809²	MINT-6489217 MINT-8079030
MAP3K3	Q99759²	MINT-47992 MINT-48392

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	IEA	--
GO:0006611	protein export from nucleus	IEA	--
GO:0006916	anti-apoptosis	TAS	16130169

About this table

HSPA9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

HSPA9 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPA9
7 Novoseek chemical compound relationships for HSPA9 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glyceraldehyde 3-phosphate	15.9	2	16220529 (1), 9504817 (1)
ouabain	15	3	12433836 (2), 17172693 (1)
atp	13.4	4	16220529 (1), 12488463 (1), 15724436 (1), 10221157 (1)
glucose	0	11	15724436 (4), 19659607 (1), 12371145 (1), 11099777 (1) (see all 5)
calcium	0	1	12687615 (1)
tyrosine	0	6	11162655 (4)
phosphatidylinositol	0	1	17635236 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for HSPA9 Sigma-Aldrich shRNA Panels and shRNA for HSPA9
		OriGene 29mer shRNA kits in GFP-retroviral vector: HSPA9 OriGene shRNA RFP: HSPA9 OriGene basic RS shRNA: HSPA9 OriGene siRNA: HSPA9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of HSPA9

miRNA:		Sigma-Aldrich microRNA Mimics for HSPA9 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of HSPA9
		2 SABiosciences Assays for microRNAs that regulate HSPA9:
		hsa-miR-767-3p hsa-miR-532-5p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: HSPA9 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: HSPA9 OriGene untagged cDNA clones in CMV expression vector: HSPA9 OriGene 3'-UTR Clone: HSPA9 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for HSPA9

Primers:		OriGene genome-wide validated SYBR primer pairs: HSPA9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for HSPA9: PPH01191A

REFSEQ mRNAs for HSPA9 gene:

NM_004134.6

Additional cDNA sequence:

AK222758.1 AK225488.1 AK293990.1 AK297795.1 AK297897.1 AK315177.1 BC000478.2 BC024034.2

BC030634.1 CR603588.1 CR613622.1 CR618446.1 DQ185038.1 DQ480334.1 L11066.1 L15189.1

24/45 DOTS entries (see all 45):

DT.97836364 DT.95288765 DT.100887123 DT.120803652 DT.101977168 DT.92407569 DT.405321 DT.95288768

DT.97766955 DT.99991700 DT.120803655 DT.120803628 DT.120803672 DT.92325858 DT.92465522 DT.97836373

DT.99943195 DT.120803599 DT.100039307 DT.100887131 DT.100887134 DT.120803668 DT.120803688 DT.95128155

24/1018 AceView cDNA sequences (see all 1018):

BU540572 CA426751 CR613622 CB158873 AW410552 AI920957 BF968357 BM836943

BE388072 BU618695 AA306603 AI383937 BM928770 AL536081 AA742294 AI810378

BP358140 CN483030 AA679742 BM462331 CR599268 BP360501 AI623586 C04924

highest scoring ESTs for HSPA9:

L15189 AA306420 AA312030 AA313292 AA314185 AA332764 AA361394 AA376265 AL518899 AL540682

Unigene Cluster for HSPA9:

Heat shock 70kDa protein 9 (mortalin)

Hs.184233 [show with all ESTs]

Unigene Representative Sequence: NM_004134

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA9 (see all 9)

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^
SP1:									-		-		-												-						-
SP2:									-		-		-						-		-		-		-		-		-		-		-		-		-		-		-
SP3:									-		-		-												-
SP4:													-												-
SP5:									-		-		-

ExUns:	14	^	15	^	16a	·	16b	^	17	^	18	^	19
SP1:					-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for HSPA9
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000297185(uc003lde.2 uc003ldf.2) ENST00000501917 ENST00000524109

ENST00000512328 ENST00000507097(uc011cyw.1) ENST00000523929 ENST00000508003

ENST00000504902 ENST00000507115 ENST00000505110 ENST00000504810 ENST00000506477

ENST00000507886

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

HSPA9 expression in normal and diseased human tissues

¹ / ² / ³

10 probe-sets matching HSPA9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
75250_s_at²^{, 3}	U95-D	1	1.00	1.00	0.98	1.17	AW023676	0.80	1.00	0.91	1
41510_s_at²^{, 3}	U95-A	2	1.00	0.94	0.98	0.83	L15189	1.00	0.90	0.95	1
200692_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004134	0.60	1.00	0.82	1
200691_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000478	0.80	0.88	0.84	1
200690_at²^{, 3}	U133-A	1	0.55	1.00	--	--	AA927701	0.40	1.00	0.76	1
232200_at*²	U133-B	NULL	0.00	0.00	--	--	--	--	--	--	--
200692_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200691_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200690_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--
232200_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

HSPA9 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

HSPA9 gene electronic northern expression

About these images

CGAP SAGE TAG: TTTGTAGATG

SOURCE GeneReport for Unigene cluster: Hs.184233

Primers:		OriGene genome-wide validated SYBR primer pairs: HSPA9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for HSPA9: PPH01191A

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA9 (see all 4): PAHS-076A PAHS-3012A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HSPA9 gene from 5/28 species (see all 28)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HSPA9¹	--	heat shock 70kDa protein 9 (mortalin)	92.49(n) 98.53(a)	474697 XM_858752.1 XP_863845.1
chimpanzee (Pan troglodytes)	HSPA9¹	--	heat shock 70kDa protein 9 (mortalin)	99.85(n) 99.85(a)	462099 XM_001171426.1 XP_001171426.1
cow (Bos taurus)	HSPA9¹	--	heat shock 70kDa protein 9 (mortalin)	92.69(n) 98.53(a)	517535 NM_001034524.1 NP_001029696.1
rat (Rattus norvegicus)	Hspa9¹	--	heat shock protein 9	90.62(n) 98.38(a)	291671 XM_214583.4 XP_214583.3
mouse (Mus musculus)	Hspa9^{1 , 5}	18 (18.80 cM)⁵	heat shock protein 9^{1, 5}	90.23(n)¹ 98.38(a)¹	15526¹ NM_010481.1¹ NP_034611.1¹ AK002634⁵ AK004946⁵ (see all 29)

About this table Species with no ortholog for HSPA9

ENSEMBL Gene Tree for HSPA9 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs7306^1,2	C,F,A	137891109(+)	`AGACAC/GAGGGC`	2	--	ut3¹ ese³		6		MN NS	368
rs10117^1,2	C,F,A,H,	137892170(-)	`CATCAT/CTGAAG`	4	/L	ref¹ syn¹		28		MN EA NA NS WA	1740
rs11032^1,2	C,F,	137891443(+)	`TAAAAT/CAGTTA`	2	--	ut3¹		6		MN NS	368
rs185342^1,2	C,F,A,	137909066(+)	`ACTTCC/GAggcc`	1	--	int¹		10		NS EA NA WA	426
rs192278^1,2	F,H	137907185(+)	`GGTATG/CTTTGC`	1	--	int¹		7		EA NA NS	470
rs256001^1,2	C,F,A,	137893425(+)	`GTTTGT/GGGGGA`	1	--	int¹		15		NS EA NA WA	1052
rs256002^1,2	C,F,O,A,	137895218(+)	`GACTAT/CCCTTT`	1	--	int¹		27		NS EA NA WA	2564
rs256003^1,2	C,F,A,	137895300(+)	`TGTTAA/CTCCTG`	1	--	int¹		16		NS EA NA WA	1148
rs256004^1,2	C,F,A,	137896128(+)	`CAACTA/CAAGAC`	1	--	int¹		11		NS EA WA	728
rs256005^1,2	C,A	137896289(+)	`gtgtcA/Gctcag`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for HSPA9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSPA9: --

QIAGEN SeqTarget long-range PCR primers for resequencing HSPA9

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPA9 for disorders About GeneDecksing

OMIM: 600548

6 Novoseek disease relationships for HSPA9 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	58	24	16817317 (1), 16619038 (1), 19280369 (1), 12687615 (1) (see all 20)
cancer	31.6	30	14728808 (3), 17306926 (3), 17389721 (2), 17934217 (2) (see all 15)
parkinson disease	27.8	4	19657588 (2), 20152901 (1), 18219256 (1)
tumors	24.2	28	17306926 (3), 16425258 (3), 17934217 (3), 9417864 (2) (see all 10)
breast carcinoma	0	1	16425258 (1)
adenocarcinoma	0	2	15532096 (2)

About this table

Human Gene Mutation Database (HGMD): HSPA9
Human Genome Epidemiology (HuGE) Navigator: HSPA9 (4 documents)

Export disorders and mutations for HSPA9 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/158 PubMed articles for HSPA9 gene, integrated from 7 sources (see all 158):
(articles sorted by number of sources associating them with HSPA9)

Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. (PubMed id 7684501)^{1, 2, 3} Domanico S.Z.... Pierce S.K. (1993)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A two-dimensional gel database of human colon carcinoma proteins. (PubMed id 9150948)^{1, 2} Ji H.... Simpson R.J. (1997)
Cloning and subcellular localization of human mitochondrial hsp70. (PubMed id 7829505)^{1, 2} Bhattacharyya T.... Morimoto R.I. (1995)
Human liver protein map: update 1993. (PubMed id 8313870)^{1, 2} Hughes G.J.... Hochstrasser D.F. (1993)
Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)^{1, 2} Hochstrasser D.F.... Hughes G.J. (1992)
Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. (PubMed id 17934217)^{1, 7} Yi X....Fan S.T. (2008)
Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31. (PubMed id 11187902)^{1, 7} Xie H....Westbrook C.A. (2000)
Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. (PubMed id 19739077)^{1, 7} Pilzer D....Fishelson Z. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3313	HGNC: 5244	AceView: HSPA9B	Ensembl:ENSG00000113013	euGenes: HUgn3313
ECgene: HSPA9	Kegg: 3313	H-InvDB: HSPA9

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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NIEHS-SNPs	http://egp.gs.washington.edu/data/hspa9b/

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HSPA9 (Gene Symbol)
heat shock 70kDa protein 9 (mortalin)
GRP75
PBP74
HSPA9B
Heat shock 70 kDa protein 9
Peptide-binding protein 74
75 kDa glucose-regulated protein
MOT
GRP-75
MOT2
mot-2
mthsp75
heat shock 70kDa protein 9B (mortalin-2)
MGC4500
MTHSP75
heat shock 70kD protein 9B
mortalin, perinuclear
mortalin-2
CSA
stress-70 protein, mitochondrial
p66-mortalin
Mortalin

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HSPA9 Gene

protein-coding GIFtS: 64

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