Aliases &
Descriptions
for HTR1E gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| 5-hydroxytryptamine (serotonin) receptor 1E1 2 | | S312 3 | | 5-HT1E1 2 3 | | OTTHUMP000000168232 | | Serotonin receptor 1E2 3 | | 5-hydroxytryptamine receptor 1E2 | | 5-HT-1E2 3 | | |
Export aliases for HTR1E gene to outside databasesPrevious GC identifers: GC06P087593 GC06P087643 GC06P087704 GC06P087647 |
Summaries
for HTR1E gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteinsthat inhibit adenylate cyclase activity
 summary
for HTR1E: Serotonin 5-ht1E receptors are primarily located in the cortex, caudate putamen, claustrum, hippocampus, and
amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15). The function of this
receptor has yet to be elucidated.
Gene Wiki entry for HTR1E (5-HT1E receptor) |
Genomic Views
for HTR1E gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for HTR1E
Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR1E
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for HTR1E  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14-q15 Ensembl cytogenetic band: 6q14.3 HGNC cytogenetic band: 6q14-q15HTR1E Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P084863: view genomic region
(about GC identifiers)
Start:
|
84,863,632 bp from pter |
End:
|
84,942,983 bp from pter |
Size:
|
79,352 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr6+ 87,647,024-87,726,401 |
RefSeq DNA sequence:- NC_000006.11 NT_007299.13
|
Proteins
for HTR1E gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 1E Size: 365 amino acids; 41682 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q9P1Y1Explore the universe of human proteins at neXtProt for HTR1E: NX_P28566
REFSEQ proteins: NP_000856.1
ENSEMBL proteins: ENSP00000358597 ENSP00000307766
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
HTR1E for ontologies About GeneDecksing
Antibodies for HTR1E:
Assays for HTR1E: |
Protein
Domains/
Families
for HTR1E gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR1E for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P28566ProtoNet protein and cluster: P28566 1 Blocks protein family: IPB002231 5-hydroxytryptamine receptor signature
UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566Similarity: Belongs to the G-protein coupled receptor 1 family |
Gene Function
for HTR1E gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteinsthat inhibit adenylate cyclase activity
Genatlas biochemistry entry for HTR1E:5-hydroxytryptamine (serotonin) receptor,subtype IE,G protein coupled receptor superfamily,inhibiting adenylate cyclase5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
HTR1E for ontologies About GeneDecksing
|
Pathways & Interactions
for HTR1E gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
HTR1E for pathways About GeneDecksing
3  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for HTR1E
1  Kegg Pathway (Kegg details for HTR1E):  | hsa04080 Neuroactive ligand-receptor interaction |
SABiosciences Pathway-Focused PCR Array including HTR1E: PAHS-3009A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for HTR1E
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR1E
5/7 Interacting proteins for HTR1E (ENSP000003585973 P285661) via UniProtKB, MINT, and/or STRING (see all 7)About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
HTR1E for ontologies About GeneDecksing
|
Drugs & Compounds
for HTR1E gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
HTR1E for compounds About GeneDecksing
Compounds for HTR1E available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| BRL 54443 | Potent 5-ht1E/F agonist | -- |
About this table
6  Novoseek chemical compound relationships for HTR1E gene
About this table
|
Transcripts
for HTR1E gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for HTR1E gene: NM_000865.2 Additional cDNA sequence: AF498980.1 BC069751.1 CR596923.1 CR606192.1 CR618239.1 CR624925.1 M91467.1 3 DOTS entries: DT.100670613 DT.91739998 DT.100661910 24/25 AceView cDNA sequences (see all 25): AF498980 BX349901 CR596923 BC069751 CR606192 CR618239 CB565887 AL561877 BX355486 AL521494 AL520002 AL561841 M91467 BX389401 NM_000865 AL520435 AL522462 AI807334 AL519220 AL521170 AL522463 AL521493 AI479667 AL521169
 highest scoring ESTs for HTR1E:M91467 AF498980 AL521493 AL522462 AL561841 AL561877 CB565887 AL520002 AL520435 BC069751 Unigene Cluster for HTR1E: 5-hydroxytryptamine (serotonin) receptor 1E Hs.1611 [show with all ESTs]Unigene Representative Sequence: CR624925
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369584 ENST00000305344(uc003pli.2)
|
Expression
for HTR1E gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| HTR1E expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching HTR1E gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33607_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
M91467 |
1.00 |
0.90 |
0.95 |
1 |
| 207404_s_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_000865 |
0.60 |
1.00 |
0.82 |
1 |
| 207404_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
HTR1E for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGTGGATGGG
SOURCE GeneReport for Unigene cluster: Hs.1611
Expression variation in blood from EXPOLDB for HTR1E SABiosciences Expression via Pathway-Focused PCR Array including HTR1E: PAHS-3009A
|
Orthologs
for HTR1E gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HTR1E gene from 5/8 species (see all 8)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
HTR1E1 |
-- |
5-hydroxytryptamine (serotonin) receptor 1E |
90.5(n)
94.52(a) |
481907 XM_539028.1 XP_539028.1 |
cow
(Bos taurus) |
HTR1E1 |
-- |
5-hydroxytryptamine (serotonin) receptor 1E |
89.13(n)
95.07(a) |
616356 XM_868360.1 XP_873453.1 |
chicken
(Gallus gallus) |
HTR1E1 |
-- |
5-hydroxytryptamine (serotonin) receptor 1E |
75.73(n)
86.81(a) |
771973 XM_001235178.1 XP_001235179.1 |
zebrafish
(Danio rerio) |
LOC5720401 |
-- |
similar to 5-hydroxytryptamine receptor 1E (5-HT-1E) more |
65.93(n)
68.14(a) |
572040 XM_695698.1 XP_700790.1 |
fruit fly
(Drosophila melanogaster) |
5-HT1A3 |
56B2--5 |
serotonin receptor signaling pathway
G-protein more |
43(a)
(best of 3) |
-- |
About this table Species with no ortholog for HTR1E
ENSEMBL Gene Tree for HTR1E (if available) |
Paralogs
for HTR1E gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HTR1E gene
- HTR1A2 ADRB12 HTR1F2 HTR72 HTR1D2 ADRB22 ADRB32 HTR5A2
- HTR1B2
HTR1E for paralogs About GeneDecksing
|
Genomic Variants
for HTR1E gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for HTR1E (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HTR1E
1 CNV: 99617 | | QIAGEN SeqTarget long-range PCR primers for resequencing HTR1E |
|
Disorders & Mutations
for HTR1E gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR1E for disorders About GeneDecksing
OMIM: 182132
Genetic Association Database (GAD): HTR1E
Human Genome Epidemiology (HuGE) Navigator: HTR1E (9 documents)
Export disorders and mutations for HTR1E gene to outside databases
|
Medical News
for HTR1E gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for HTR1E gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/26 PubMed articles for HTR1E gene, integrated from 7 sources (see all 26):
(articles sorted by number of sources associating them with HTR1E)- Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. (PubMed id 1608964)1, 2, 3 McAllister G.... Whiting P. (1992)
- Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. (PubMed id 1733778)1, 2, 7 Levy F.O.... Birnbaumer L. (1992)
- Human gene S31 encodes the pharmacologically defined serotonin 5- hydroxytryptamine1E receptor. (PubMed id 1513320)1, 2, 7 Zgombick J.M....Weinshank R.L. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. (PubMed id 12627464)1, 4 Turecki G....Rouleau G.A. (2003)
- Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)1, 2 Cargill M....Lander E.S. (1999)
- Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15. (PubMed id 8001977)1, 7 Levy F.O....Gudermann T. (1994)
- 5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study. (PubMed id 9316030)1, 7 Pierce P.A....Peroutka S.J. (1997)
- Association study of the serotoninergic system in mig raine in the Spanish population. (PubMed id 19455600)1 Corominas R....Cormand B. (2010)
|
External Searches for HTR1E gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HTR1E gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HTR1E gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR1E gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HTR1E gene:
Search GeneIP for patents involving HTR1E
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HTR1E gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Tocris compounds for HTR1E |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for HTR1E |
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