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ID2 Gene

protein-coding   GIFtS: 62

GC02P008605
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for ID2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein1 2     inhibitor of differentiation 22
bHLHb261 2 3     OTTHUMP000002002972
GIG81 2     ID2A2
Class B basic helix-loop-helix protein 262 3     ID2H2
DNA-binding protein inhibitor ID-22     helix-loop-helix protein ID22
DNA-binding protein inhibitor ID22     cell growth-inhibiting gene 82
MGC263892     BHLHB263
OTTHUMP000001402582     Inhibitor of DNA binding 23

External Ids:    HGNC: 53611   Entrez Gene: 33982   Ensembl: ENSG000001157387   UniProtKB: Q023633   

Export aliases for ID2 gene to outside databases

Previous GC identifers: GC02P008873 GC02P008843 GC02P008772


Summaries
for ID2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ID2:
The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are
transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID
family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by
suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively
regulating cell differentiation. A pseudogene has been identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers
with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression

Gene Wiki entry for ID2

Genomic Views
for ID2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ID2 gene promoter:
         COUP-TF1   HNF-4alpha2   p53   FOXC1   FOXO3b   FOXO3a   FOXF2   NF-E2   NF-E2 p45   FOXD1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ID2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ID2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID2 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P008605:  view genomic region     (about GC identifiers)

Start:
 8,668,297 bp from pter
End:
 8,670,767 bp from pter
Size:
 2,471 bases
Orientation:
 plus strand

1 alternative location:
Chr2+ 8,818,975-8,824,583     
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  

Proteins
for ID2 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-2  
Size: 134 amino acids; 14917 Da
Subunit: Heterodimer with other HLH proteins
Subcellular location: Nucleus
Developmental stage: Found in most early fetal tissues but not in the corresponding mature tissues

Explore the universe of human proteins at neXtProt for ID2: NX_Q02363 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002157.2  

    ENSEMBL proteins: 
    ENSP00000379585 ENSP00000385465 ENSP00000234091 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ID2
    OriGene Protein Over-expression Lysate: ID2
    GenScript Custom Purified and Recombinant Proteins Services for ID2 
    Novus Biologicals Proteins for ID2
    Novus Biologicals Lysates for ID2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785 chromatin IEA--
    GO:0005634 nucleus IDA18029348
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    GO:0005829 cytosol IEA--
    About this table

    ID2 for ontologies           About GeneDecksing



    Antibodies for ID2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ID2
    R&D Systems Antibodies for ID2
    Cell Signaling Technology (CST) Antibodies for ID2 
    OriGene Antibodies (see all 2): ID2
    GenScript Custom Superior Antibodies Services for ID2 
    Novus Biologicals Antibodies for ID2
    Browse antibodies at Epitomics

    Assays for ID2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ID2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ID2 

    Protein Domains/
    Families
    for ID2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ID2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001092 HLH_DNA-bd_dom
     IPR011598 HLH_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q02363

    ProtoNet protein and cluster: Q02363

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Similarity: Contains 1 basic helix-loop-helix (bHLH) domain


    Gene Function
    for ID2 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers
    with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ID2
    Sigma-Aldrich shRNA for ID2
    OriGene 29mer shRNA kits in GFP-retroviral vector: ID2
    OriGene shRNA RFP: ID2
    OriGene basic RS shRNA: ID2
    OriGene siRNA: ID2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ID2 
    miRNA:Sigma-Aldrich microRNA Mimics for ID2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ID2 
    8/11 SABiosciences Assays for microRNAs that regulate ID2 (see all 11):
    hsa-miR-1237 hsa-miR-300 hsa-miR-381 hsa-miR-618 hsa-miR-1179 hsa-miR-340 hsa-miR-513b hsa-miR-298

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ID2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ID2
    OriGene untagged cDNA clones in CMV expression vector: ID2
    OriGene 3'-UTR clone: ID2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ID2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for ID2 

    Genatlas biochemistry entry for ID2:
    inhibitor of DNA binding 2,putative transcription regulator,expressed during early development,inhibiting transcription
    factors of the basic helix loop helix family

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI10915743
    GO:0016563 transcription activator activity ----
    GO:0016564 transcription repressor activity IDA14627819
    GO:0030528 transcription regulator activity ----
    About this table

    ID2 for ontologies           About GeneDecksing

    Animal Models: 15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Id2) (see all 16):

    adipose tissuebehavior/neurologicalcellulardigestive/alimentaryendocrine/exocrine gland
    growth/sizehematopoietic systemimmune systemlethality-postnatallife span-post-weaning/aging
    nervous systemno phenotypic analysisrenal/urinary systemreproductive systemtaste/olfaction

    ID2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ID2 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ID2 for pathways           About GeneDecksing

    3 Millipore Pathways for ID2
        Selected targets of C/EBPbeta
    Selected targets of Oct-3/4
    Selected targets of CREB1

    1 Kegg Pathway  (Kegg details for ID2):
        hsa04350 TGF-beta signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including ID2: PAHS-005A PAHS-035A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ID2

    5/10 Interacting proteins for ID2 (Q023631, 2 ENSP000002340913) via UniProtKB, MINT, and/or STRING (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF3P15923-11, ENSP000002629653EBI-713450,EBI-769645 STRING: ENSP00000262965
    C1orf103Q5T3J32MINT-64030
    UNC119Q134322MINT-64029
    TCF4ENSP000003464403STRING: ENSP00000346440
    ARNTENSP000003156373STRING: ENSP00000315637
    About this table

    5/22 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 22):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0003166 bundle of His development IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0007507 heart development IEA--
    GO:0008284 positive regulation of cell proliferation IEA--
    About this table

    ID2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ID2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ID2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ID2
    9 Novoseek chemical compound relationships for ID2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 21.4 9 19260835 (2), 15831462 (2), 17393418 (1), 19180920 (1)
    phosphatidylinositol 11.1 1 16150928 (1)
    bromodeoxyuridine 9.61 1 19609365 (1)
    oligonucleotide 9.04 1 12670915 (1)
    retinoic acid 8.53 7 17310985 (2), 16549780 (1), 14582708 (1)
    butyrate 7.36 1 10330158 (1)
    calcitriol 5.17 1 16007183 (1)
    estrogen 0 2 15809228 (1), 19257909 (1)
    dexamethasone 0 3 11317672 (2), 12424200 (1)
    About this table



    Transcripts
    for ID2 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ID2
    Sigma-Aldrich shRNA for ID2
    OriGene 29mer shRNA kits in GFP-retroviral vector: ID2
    OriGene shRNA RFP: ID2
    OriGene basic RS shRNA: ID2
    OriGene siRNA: ID2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ID2 
    miRNA: Sigma-Aldrich microRNA Mimics for ID2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ID2 
    8/11 SABiosciences Assays for microRNAs that regulate ID2 (see all 11):
    hsa-miR-1237 hsa-miR-300 hsa-miR-381 hsa-miR-618 hsa-miR-1179 hsa-miR-340 hsa-miR-513b hsa-miR-298
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ID2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ID2
    OriGene untagged cDNA clones in CMV expression vector: ID2
    OriGene 3'-UTR Clone: ID2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ID2 
    Primers: OriGene genome-wide validated SYBR primer pairs: ID2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ID2: PPH00414A

    REFSEQ mRNAs for ID2 gene: 

    NM_002166.4  

    Additional cDNA sequence: 

    AK222682.1 AK311988.1 AY634687.1 BC030639.2 CR607131.1 CR611001.1 CR614653.1 CR620423.1 
    CR620531.1 CR623038.1 CR626410.1 D13891.1 M97796.1 

    17 DOTS entries:

    DT.102824856  DT.92437989  DT.100818571  DT.100818572  DT.100818580  DT.100818582  DT.419995  DT.100722779 
    DT.95334744  DT.100818570  DT.92437995  DT.100697819  DT.120992816  DT.120992827  DT.92437991  DT.100818576 
    DT.91990899 

    24/483 AceView cDNA sequences (see all 483):

    AV706301 BP380292 BM785380 CR611001 CB107753 CR620423 AI087021 CR607131 
    BU521193 AA128163 BF035729 AI923540 CD677353 BU687176 BQ269932 AI346160 
    CB154889 BU742429 AI342472 N46821 BM126985 AI686940 BU738915 CR614653 

    highest scoring ESTs for ID2:

    D13891 AA151620 AA524819 AA526652 AA557557 AA594299 AA625292 AA946931 AI076720 AI087021 

    Unigene Cluster for ID2:

    Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
    Hs.180919  [show with all ESTs]
    Unigene Representative Sequence: CR623038


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396290 ENST00000472142 ENST00000331129 ENST00000234091(uc010yiu.1 uc002qza.2)


    Expression
    for ID2 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ID2 expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching ID2 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41216_r_at2, 3 U95-A 1 0.88 1.00 0.70 0.15 D13891 1.00 0.90 0.95 1
    64354_f_at2, 3 U95-C 2 0.88 0.89 0.99 1.04 AA557557 0.80 1.00 0.91 1
    41215_s_at2, 3 U95-A 2 0.81 0.87 0.99 0.96 D13891 1.00 0.90 0.95 1
    201565_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002166 0.60 1.00 0.82 1
    201566_x_at2, 3 U133-A 2 0.82 0.94 -- -- D13891 1.00 0.90 0.95 1
    201565_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    201566_x_at2 U133Plus2 2 0.82 0.94 -- -- -- -- -- -- --
    About this table

    ID2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ID2 gene expression
    ID2 gene electronic northern expression
    ID2 gene sage expression
    About these images

    CGAP SAGE TAG: TCTGAAGTCA

    SOURCE GeneReport for Unigene cluster: Hs.180919

    Expression variation in blood from EXPOLDB for ID2

    UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system

    Primers: OriGene genome-wide validated SYBR primer pairs: ID2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ID2: PPH00414A
        SABiosciences Expression via Pathway-Focused PCR Arrays including ID2: PAHS-005A PAHS-035A 


    Orthologs
    for ID2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ID2 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    cow
    (Bos taurus)    		 ID21   -- inhibitor of DNA binding 2, dominant negative helix-loop-helix more 94.53(n)
    98.51(a)    		 505025  NM_001034231.1  NP_001029403.1 
    rat
    (Rattus norvegicus)    		 Id21   -- inhibitor of DNA binding 2 94.03(n)
    97.76(a)    		 25587  NM_013060.2  NP_037192.1 
    mouse
    (Mus musculus)    		 Id21 , 5 12 (8.57 cM)5
    		 inhibitor of DNA binding 21, 5 95.02(n)1
    98.51(a)1    		 159021  NM_010496.21  NP_034626.11 
     AF0778605  AF0778615  (see all 17)
    chicken
    (Gallus gallus)    		 ID21   -- inhibitor of DNA binding 2, dominant negative helix-loop-helix more 86.32(n)
    94.03(a)    		 395852  NM_205002.1  NP_990333.1 
    zebrafish
    (Danio rerio)    		 id22   -- inhibitor of DNA binding 2, dominant negative helix-loop-helix more 78.85(n) 266599  AY398363.1 
    About this table        Species with no ortholog for ID2

    ENSEMBL Gene Tree for ID2 (if available)

    Paralogs
    for ID2 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ID2 gene
    ID12  ID32  ID42  

    ID2 for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    Genomic Variants
    for ID2 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/74 NCBI SNPs in ID2 are shown (see all 74)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs48991,2
    		C8822613(+) ACCCTC/GAACAC 2 L ref1 syn10--------
    rs10646531,2
    		--8823935(+) TTTTTA/TAAAAA 1 -- ut310--------
    rs13179661,2
    		C,A8820446(-) TTCCCC/TAGGCC 1 -- ng511Minor allele frequency- T:0.00MN 184
    rs18025491,2
    		--8824090(+) ATGGGA/GAGCGA 1 -- ut310--------
    rs18025501,2
    		--8824095(+) GAGCGA/GAAACG 1 -- ut310--------
    rs22417401,2
    		C,F,8820584(+) TGGGGC/AGCATA 1 -- ng518Minor allele frequency- A:0.20EA NS NA 1666
    rs23060671,2
    		C,F,H,8823553(+) GAAGCA/GGACTG 1 -- int112Minor allele frequency- G:0.20EA NS NA 2438
    rs30536711,2
    		--8823097(+) CGCGC-/GCATGTG 1 -- int10--------
    rs38457511,2
    		C,A,8822912(+) aaaaaC/Aaaaaa 1 -- int1 trp35Minor allele frequency- A:0.33NA WA 128
    rs39007951,2
    		--8824987(-) GTACAG/ACCTCT 1 -- ng311Minor allele frequency- A:0.00MN 184
    About this table

    HapMap Linkage Disequilibrium images for ID2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ID2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ID2 

    Disorders & Mutations
    for ID2 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ID2 for disorders           About GeneDecksing

    OMIM: 600386

    10/15 Novoseek disease relationships for ID2 gene (see all 15)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 56.4 13 11034201 (2), 15831462 (1), 16733829 (1), 16549780 (1) (see all 10)
    ewings sarcoma 41.7 10 16869242 (7), 12527902 (3)
    tumors 38.2 45 20388805 (5), 12545167 (3), 16549780 (3), 12447693 (2) (see all 24)
    cancer 12.2 7 12447693 (1), 16733829 (1), 9731481 (1), 18413820 (1) (see all 6)
    lymphoma 10.4 7 15492249 (2), 18085637 (1), 8632670 (1)
    colon carcinoma 3.22 5 11572874 (2), 16007183 (1)
    leukemia 0 2 8632670 (1), 15492249 (1)
    primary tumor 0 1 12447693 (1)
    glioma 0 2 7622574 (1), 12007145 (1)
    hypertrophy 0 2 16002773 (1), 15601750 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: ID2 (5 documents)

    Export disorders and mutations for ID2 gene to outside databases

    Medical News
    for ID2 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for ID2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/209 PubMed articles for ID2 gene, integrated from 7 sources (see all 209):
    (articles sorted by number of sources associating them with ID2)
    1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PubMed id 8294468)1, 2, 3 Hara E....Oda K. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A human Id-like helix-loop-helix protein expressed during early development. (PubMed id 1741406)1, 2 Biggs J.... Israel M.A. (1992)
    4. Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors. (PubMed id 19257909)1, 7 Meng Y....Han W. (2009)
    5. Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. (PubMed id 19010462)1, 7 Weigent D.A. (2009)
    6. The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas. (PubMed id 18085637)1, 7 Cotta C.V....Rassidakis G.Z. (2008)
    7. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. (PubMed id 16549780)1, 7 Lasorella A. and Iavarone A. (2006)
    8. Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. (PubMed id 15252039)1, 7 Lofstedt T....Axelson H. (2004)
    9. FHL2 interacts with and acts as a functional represso r of Id2 in human neuroblastoma cells. (PubMed id 19417068)1, 7 Han W....Yu L. (2009)
    10. The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. (PubMed id 12447693)1, 7 Nishimori H....Tokino T. (2002)

    External Searches for ID2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ID2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3398 HGNC: 5361 AceView: ID2 Ensembl:ENSG00000115738 euGenes: HUgn3398
    ECgene: ID2 Kegg: 3398 H-InvDB: ID2

    Other Databases showing ID2 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing ID2 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ID2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ID2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    		Patent Information for ID2 gene:
    Search GeneIP for patents involving ID2

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