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IGFBP7 Gene

protein-coding GIFtS: 58

GC04M053850

insulin-like growth factor binding protein 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
insulin-like growth factor binding protein 7¹ ²		IBP-7² ³
MAC25¹ ² ³ ⁵		TAF² ³
IGFBP-7¹ ² ³		PGI2-stimulating factor² ³
PSF¹ ² ³		insulin-like growth factor-binding protein 7²
FSTL2¹ ²		IGFBPRP1²
Prostacyclin-stimulating factor² ³		IGFBP-7v²
Tumor-derived adhesion factor² ³		angiomodulin²
IGFBP-rP1² ³		AGM²
IGF-binding protein 7² ³		MAC25 protein³

External Ids:	HGNC: 5476¹	Entrez Gene: 3490²	Ensembl: ENSG00000163453⁷	UniProtKB: Q16270³

Export aliases for IGFBP7 gene to outside databases

Previous GC identifers: GC04M057701 GC04M057893 GC04M057812 GC04M057738 GC04M057592

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270

Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates

cell adhesion

Gene Wiki entry for IGFBP7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGFBP7 gene promoter:
         IRF-7A   AP-2alphaA   AP-2gamma   Sox9   IRF-1   ATF   Nkx6-1   FOXJ2 (long isoform)   Lmo2   CUTL1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for IGFBP7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for IGFBP7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q12

IGFBP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGFBP7 gene location

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M053850: view genomic region (about GC identifiers)

Start:	53,850,818 bp from pter
End:	53,930,079 bp from pter
Size:	79,262 bases
Orientation:	minus strand

1 alternative location:

Chr4- 57,896,939-57,976,551

RefSeq DNA sequence:

NC_000004.11 NT_022853.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270 (See protein sequence)

Recommended Name: Insulin-like growth factor-binding protein 7 precursor

Size: 282 amino acids; 29130 Da

Subunit: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear

Subcellular location: Secreted

Rna editing: Modified_positions=78, 95; Note=Partially edited. In the brain, position 78 is edited at about 55% and

position 95 at about 31%

Secondary accessions: Q07822 Q53YE6 Q9UCA8

Explore the universe of human proteins at neXtProt for IGFBP7: NX_Q16270

Post-translational modifications:

N-glycosylated¹

REFSEQ proteins: NP_001544.1

ENSEMBL proteins:

ENSP00000295666

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IGFBP7 (IGFBP-rp1/IGFBP-7)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IGFBP7
	GenScript Custom Purified and Recombinant Proteins Services for IGFBP7
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IDA	--
GO:0031012	colocalizes with extracellular matrix	IDA	--

About this table

IGFBP7 for ontologies About GeneDecksing

Antibodies for IGFBP7:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IGFBP7
	R&D Systems Antibodies for IGFBP7 (IGFBP-rp1/IGFBP-7)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for IGFBP7
	Novus Biologicals Antibodies for IGFBP7
	Browse antibodies at Epitomics

Assays for IGFBP7:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IGFBP7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGFBP7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGFBP7 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR007110 Ig-like

IPR002350 Prot_inh_Kazal

IPR003599 Ig_sub

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q16270

ProtoNet protein and cluster: Q16270

3 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB011497 Protease inhibitor

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 Kazal-like domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: IBP7_HUMAN, Q16270

Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates

cell adhesion

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IGFBP7 Sigma-Aldrich shRNA for IGFBP7
		OriGene 29mer shRNA kits in GFP-retroviral vector: IGFBP7 OriGene shRNA RFP: IGFBP7 OriGene basic RS shRNA: IGFBP7 OriGene siRNA: IGFBP7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGFBP7

miRNA:		Sigma-Aldrich microRNA Mimics for IGFBP7 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGFBP7
		Search SABiosciences for Assays for microRNAs that regulate IGFBP7

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IGFBP7 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IGFBP7 OriGene untagged cDNA clones in CMV expression vector: IGFBP7 OriGene 3'-UTR clone: IGFBP7 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IGFBP7
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for IGFBP7

Genatlas biochemistry entry for IGFBP7:

insuline-like growth factor binding protein 7 (related protein 1),expressed in both in situ and invasive neoplasm and

increased in senescent cells

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	9388210
GO:0005520	insulin-like growth factor binding	IEA	--

About this table

IGFBP7 for ontologies About GeneDecksing

Animal Models: 1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Igfbp7):

no phenotypic analysis

IGFBP7 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

IGFBP7 for pathways About GeneDecksing

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for IGFBP7

	Inositol Metabolism
	IGF-1 Signaling

SABiosciences Pathway-Focused PCR Array including IGFBP7: PAHS-050A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IGFBP7

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IGFBP7

5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0007155	cell adhesion	IDA	8117260
GO:0007566	embryo implantation	IEA	--
GO:0008285	negative regulation of cell proliferation	TAS	8939990
GO:0009408	response to heat	IEA	--

About this table

IGFBP7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

IGFBP7 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGFBP7
9 Novoseek chemical compound relationships for IGFBP7 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine	66.9	3	19094461 (1), 17236181 (1), 19638426 (1)
prostacyclin	63.4	25	8435236 (3), 7980422 (3), 1837513 (3), 8982858 (2) (see all 12)
agar	35	2	10344746 (1), 17465992 (1)
txb2	20.9	1	1837513 (1)
retinoic acid	19	9	7538673 (2), 11295114 (1), 11089538 (1)
vegf	4.13	2	19374835 (2)
serine	4.03	1	16420484 (1)
glucose	0	10	15027891 (3), 9313760 (3), 16873698 (1)
estrogen	0	5	17545519 (1), 11429696 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IGFBP7 Sigma-Aldrich shRNA for IGFBP7
		OriGene 29mer shRNA kits in GFP-retroviral vector: IGFBP7 OriGene shRNA RFP: IGFBP7 OriGene basic RS shRNA: IGFBP7 OriGene siRNA: IGFBP7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGFBP7

miRNA:		Sigma-Aldrich microRNA Mimics for IGFBP7 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGFBP7
		Search SABiosciences for Assays for microRNAs that regulate IGFBP7

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: IGFBP7 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IGFBP7 OriGene untagged cDNA clones in CMV expression vector: IGFBP7 OriGene 3'-UTR Clone: IGFBP7 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: IGFBP7

Primers:		OriGene genome-wide validated SYBR primer pairs: IGFBP7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IGFBP7: PPH05831A

REFSEQ mRNAs for IGFBP7 gene:

NM_001553.1

Additional cDNA sequence:

AF540057.1 AK303915.1 AK316082.1 BC017201.2 BC066339.1 BT006654.1 BX648756.1 CR599263.1

CR607474.1 CR612946.1 CR615138.1 CR619194.1 CR619713.1 CR626227.1 L19182.1 S75725.1

24/26 DOTS entries (see all 26):

DT.95170564 DT.97760173 DT.40205446 DT.92040454 DT.100045783 DT.95170547 DT.95170563 DT.91955903

DT.92413462 DT.100674865 DT.100674866 DT.95170568 DT.100674872 DT.121219229 DT.121219282 DT.121219324

DT.121219400 DT.95104371 DT.95313534 DT.97812821 DT.118707 DT.121219304 DT.451262 DT.91980279

24/688 AceView cDNA sequences (see all 688):

BU948156 CD679099 CA952677 BF056097 AA557124 AA730101 AW517171 BM314525

CA942661 AW074676 CA447588 BU730944 BQ773909 BF725225 CD517905 AA653623

AI923605 AW572072 AA151485 BM673354 BM091458 AW192242 AI138712 AI755056

highest scoring ESTs for IGFBP7:

L19182 AA341077 BF967200 BG495848 BI909939 BM509054 BM689029 BQ948560 CN481182 CN481391

Unigene Cluster for IGFBP7:

Insulin-like growth factor binding protein 7

Hs.479808 [show with all ESTs]

Unigene Representative Sequence: BX648756

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP7

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b
SP1:															-		-
SP2:							-		-						-		-
SP3:
SP4:							-

About this scheme

ECgene alternative splicing isoforms for IGFBP7
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000295666(uc003hcn.2 uc011cag.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IGFBP7 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching IGFBP7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2062_at²^{, 3}	U95-A	1	0.56	1.00	1.00	1.00	L19182	1.00	0.90	0.95	1
201162_at²^{, 3}	U133-A	1	0.82	1.00	--	--	NM_001553	0.60	1.00	0.82	1
201163_s_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_001553	0.60	1.00	0.82	1
201162_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
201163_s_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

IGFBP7 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

IGFBP7 gene electronic northern expression

About these images

CGAP SAGE TAG: CATATCATTA TTTCCTTCAT

SOURCE GeneReport for Unigene cluster: Hs.479808

Expression variation in blood from EXPOLDB for IGFBP7

Primers:		OriGene genome-wide validated SYBR primer pairs: IGFBP7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for IGFBP7: PPH05831A

SABiosciences Expression via Pathway-Focused PCR Array including IGFBP7: PAHS-050A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IGFBP7 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IGFBP7¹	--	insulin-like growth factor binding protein 7	95.04(n) 93.97(a)	608559 XM_845177.1 XP_850270.1
chimpanzee (Pan troglodytes)	IGFBP7¹	--	insulin-like growth factor binding protein 7	99.43(n) 100(a)	461304 XM_517274.2 XP_517274.2
cow (Bos taurus)	IGFBP7¹	--	insulin-like growth factor binding protein 7	95.39(n) 95.74(a)	616368 XM_868373.2 XP_873466.2
rat (Rattus norvegicus)	Igfbp7¹	--	insulin-like growth factor binding protein 7	91.22(n) 91.1(a)	289560 NM_001013048.1 NP_001013066.1
mouse (Mus musculus)	Igfbp7^{1 , 5}	5 (41.71 cM)⁵	insulin-like growth factor binding protein 7^{1, 5}	90.87(n)¹ 90.75(a)¹	29817¹ NM_008048.2¹ NP_032074.2¹ AA200937⁵ AB012886⁵ (see all 20)

About this table Species with no ortholog for IGFBP7

ENSEMBL Gene Tree for IGFBP7 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IGFBP7 gene

KAZALD1² IGFBPL1²

IGFBP7 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs876858^1,2	C,F,A,	57914919(+)	`CACTCC/GCCAGC`	1	--	int¹		17		NA EA NS WA	1250
rs881382^1,2	C,F,A,H,	57917346(-)	`TCATCC/ACCTTC`	1	--	int¹ trp³		9		NS EA NA WA	626
rs1054653^1,2	F	57897871(-)	`GTCAAG/ACCATG`	1	--	int¹		1		MN	186
rs1064798^1,2	--	57935845(-)	`TTtttG/Ttttgt`	1	--	int¹		0	--	--	--	--
rs1111626^1,2	C,A,H,	57953240(+)	`GAGACG/CGACAC`	1	--	int¹		7		NA WA	14
rs1111627^1,2	C,H,	57953550(+)	`ACTAAC/TGAAGG`	1	--	int¹		7		NA	84
rs1111628^1,2	C,F,A,H,	57953687(+)	`AGTCCG/CTGGGC`	1	--	int¹		13		NS EA NA WA	552
rs1111629^1,2	C,H,	57953774(+)	`TATACA/GCAAGG`	1	--	int¹		8		NA WA	136
rs1133243^1,2	--	57976234(-)	`GCGGAA/GGGGTA`	2	K R	ref¹ mis¹ ese³		1		MN	184
rs1277272^1,2	C,F,A,H,	57909388(-)	`CCCAGG/ACTGCC`	1	--	int¹		30		EA NA NS MN WA	2120

About this table

HapMap Linkage Disequilibrium images for IGFBP7 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGFBP7: --

QIAGEN SeqTarget long-range PCR primers for resequencing IGFBP7

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGFBP7 for disorders About GeneDecksing

OMIM: 602867

10/24 Novoseek disease relationships for IGFBP7 gene (see all 24)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetic angiopathies	56.9	2	8674874 (2)
bladder carcinoma	36.7	2	17465992 (1), 14521955 (1)
tumors	32.3	45	17136345 (4), 11429696 (4), 10344746 (2), 18701096 (2) (see all 21)
colon cancer	29.8	5	18981723 (1), 17334979 (1), 17465992 (1), 9605951 (1)
colorectal cancer	29.4	14	19094461 (6), 18701096 (3), 15027891 (2), 17136345 (1) (see all 5)
prostate cancer	28.5	22	14633696 (6), 10344746 (3), 10383131 (3), 9851777 (1) (see all 7)
benign prostatic hyperplasia	21.4	1	14633696 (1)
breast cancer	19.3	12	17634530 (4), 15979304 (2), 11295114 (1), 9449045 (1) (see all 7)
cancer	16.8	13	15027891 (4), 8939990 (1), 11295114 (1), 11400113 (1) (see all 8)
meningioma	11	2	11089538 (1), 7538673 (1)

About this table

1 PharmGKB disease relationship for IGFBP7 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Genetic Association Database (GAD): IGFBP7
Human Genome Epidemiology (HuGE) Navigator: IGFBP7 (2 documents)

Export disorders and mutations for IGFBP7 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/122 PubMed articles for IGFBP7 gene, integrated from 7 sources (see all 122):
(articles sorted by number of sources associating them with IGFBP7)

Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells. (PubMed id 7980422)^{1, 2, 3, 7} Yamauchi T....Nawata H. (1994)
Identification and characterization of genes differentially expressed in meningiomas. (PubMed id 7694637)^{1, 2, 3} Murphy M.... George D.L. (1993)
Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. (PubMed id 8939990)^{1, 2, 7} Oh Y....Rosenfeld R.G. (1996)
Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)^{1, 4} Kawahara C....Loughlin J. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. (PubMed id 11549700)^{1, 2} Wilson E.M.... Rosenfeld R.G. (2001)
Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells. (PubMed id 8117260)^{1, 2} Akaogi K.... Miyazaki K. (1994)
Circulating IGF-binding protein 7 (IGFBP7) levels are elevated in patients with endometriosis or undergoing diabetic hemodialysis. (PubMed id 19019211)^{1, 7} Kutsukake M....Tamura K. (2008)
Immunohistochemical study of prostacyclin-stimulating factor (PSF) in the diabetic and atherosclerotic human coronary artery. (PubMed id 9313760)^{1, 7} Sekiguchi N....Nawata H. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3490	HGNC: 5476	AceView: IGFBP7	Ensembl:ENSG00000163453	euGenes: HUgn3490
ECgene: IGFBP7	H-InvDB: IGFBP7

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for IGFBP7	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/igfbp7/

Intellectual Property for IGFBP7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for IGFBP7 gene:
Search GeneIP for patents involving IGFBP7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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	Antibodies for IGFBP7 (IGFBP-rp1/IGFBP-7)		Cell Culture Products
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for IGFBP7 (IGFBP-rp1/IGFBP-7)

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Search for Antibodies & Assays

	Regulatory tfbs in IGFBP7 promoter
	Search Chromatin IP Primers for IGFBP7
	RT² qPCR Primer Assay for IGFBP7
	GNC Network for IGFBP7
	Search for Assays for microRNAs that regulate IGFBP7
	SABiosciences PCR Arrays including IGFBP7

Search Tocris compounds for IGFBP7

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ELISAs and CLIAs for IGFBP7

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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IGFBP7 gene at Home site.

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IGFBP7 Gene

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