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IGHD4-11 Gene

protein-coding   GIFtS: 14

GC14M106396
immunoglobulin heavy diversity 4-11 (non-functional)
(Previous name: immunoglobulin heavy diversity 4-11 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for IGHD4-11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
immunoglobulin heavy diversity 4-11 (non-functional)1 2
IGHD4111 2
DA11 2
immunoglobulin heavy diversity 4-111

External Ids:    HGNC: 55021   Entrez Gene: 284952   Ensembl: ENSG000002325437   

Export aliases for IGHD4-11 gene to outside databases

Previous GC identifers: GC14U990250 GC14M104341 GC14M105440


Summaries
for IGHD4-11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGHD4-11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHD4-11
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IGHD4-11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.32-q32.33

IGHD4-11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHD4-11 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M106396:  view genomic region     (about GC identifiers)

Start:
 106,369,474 bp from pter
End:
 106,369,489 bp from pter
Size:
 16 bases
Orientation:
 minus strand

1 alternative location:
Chr14- 86,502,519-86,502,534     

Proteins
for IGHD4-11 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section


ENSEMBL proteins: 
ENSP00000430034 


Human Recombinant Proteins 
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Antibodies for IGHD4-11: 
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Assays for IGHD4-11: 
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Protein Domains/
Families
for IGHD4-11 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Gene Function
for IGHD4-11 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGHD4-11 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHD4-11 
Search SABiosciences for Assays for microRNAs that regulate IGHD4-11

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Browse OriGene untagged/tagged cDNA clones in CMV expression vector
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
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Browse Sino Biological Human cDNA Clones

Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for IGHD4-11 


Pathways & Interactions
for IGHD4-11 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for IGHD4-11 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHD4-11

Drugs & Compounds
for IGHD4-11 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHD4-11


Transcripts
for IGHD4-11 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGHD4-11 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHD4-11 
Search SABiosciences for Assays for microRNAs that regulate IGHD4-11
Clones: Browse FLAG tag genes at Sigma-Aldrich
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for IGHD4-11 
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGHD4-11

highest scoring ESTs for IGHD4-11:

U05891 U32601 U81053 U81073 S55104 U81055 U81057 U81058 U81059 U81060 


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000431440

Expression
for IGHD4-11 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IGHD4-11 expression in normal and diseased human tissues

1  / 2  / 3

26 probe-sets matching IGHD4-11 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
216557_x_at*2 U133-A 244 0.82 0.01 -- -- -- -- -- -- --
217236_x_at*2 U133-A 199 0.64 0.01 -- -- -- -- -- -- --
211878_at*2, 3 U133-A 122 0.64 0.01 -- -- M26463 0.20 0.00 0.14 2
234792_x_at*2 U133-B 98 0.55 0.02 -- -- -- -- -- -- --
211649_x_at*2 U133-A 212 0.46 0.02 -- -- -- -- -- -- --
217384_x_at*2 U133-A 167 0.46 0.01 -- -- -- -- -- -- --
217198_x_at*2 U133-A 202 0.46 0.01 -- -- -- -- -- -- --
234419_x_at*2 U133-B 176 0.46 0.01 -- -- -- -- -- -- --
217360_x_at*2 U133-A 169 0.36 0.01 -- -- -- -- -- -- --
211638_at*2, 3 U133-A 158 0.36 0.01 -- -- L23517 0.20 0.00 0.14 2
234477_at*2 U133-B 177 0.27 0.01 -- -- -- -- -- -- --
211636_at*2 U133-A 145 0.27 0.01 -- -- -- -- -- -- --
217169_at*2 U133-A 124 0.27 0.01 -- -- -- -- -- -- --
216557_x_at*2 U133Plus2 244 0.82 0.01 -- -- -- -- -- -- --
217236_x_at*2 U133Plus2 199 0.64 0.01 -- -- -- -- -- -- --
211878_at*2 U133Plus2 122 0.64 0.01 -- -- -- -- -- -- --
234792_x_at*2 U133Plus2 98 0.55 0.02 -- -- -- -- -- -- --
211649_x_at*2 U133Plus2 212 0.46 0.02 -- -- -- -- -- -- --
217384_x_at*2 U133Plus2 167 0.46 0.01 -- -- -- -- -- -- --
217198_x_at*2 U133Plus2 202 0.46 0.01 -- -- -- -- -- -- --
234419_x_at*2 U133Plus2 176 0.46 0.01 -- -- -- -- -- -- --
217360_x_at*2 U133Plus2 169 0.36 0.01 -- -- -- -- -- -- --
211638_at*2 U133Plus2 158 0.36 0.01 -- -- -- -- -- -- --
234477_at*2 U133Plus2 177 0.27 0.01 -- -- -- -- -- -- --
211636_at*2 U133Plus2 145 0.27 0.01 -- -- -- -- -- -- --
217169_at*2 U133Plus2 124 0.27 0.01 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
IGHD4-11 gene expression
IGHD4-11 gene electronic northern expression
IGHD4-11 gene sage expression
About these images

CGAP SAGE TAG: --
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGHD4-11
    SABiosciences Custom PCR Arrays for IGHD4-11 


Orthologs
for IGHD4-11 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
 ENSEMBL Gene Tree for IGHD4-11 (if available)

Paralogs
for IGHD4-11 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

Genomic Variants
for IGHD4-11 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
Search QIAGEN SeqTarget long-range PCR primers for resequencing for IGHD4-11 

Disorders & Mutations
for IGHD4-11 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for IGHD4-11 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for IGHD4-11 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

1 PubMed article for IGHD4-11 gene integrated from 7 sources:
(articles sorted by number of sources associating them with IGHD4-11)
  1. Organization of human immunoglobulin heavy chain diversity gene loci. (PubMed id 3243276)1, 3 Ichihara Y....Kurosawa Y. (1988)

External Searches for IGHD4-11 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHD4-11 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28495 HGNC: 5502 Ensembl:ENSG00000232543 euGenes: HUgn28495 ECgene: IGHD4-11
H-InvDB: IGHD4-11

Other Databases showing IGHD4-11 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHD4-11 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
IMGT entry for IGHD4-11 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHD4-11 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for IGHD4-11 gene:
Search GeneIP for patents involving IGHD4-11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGHD4-11 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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