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IGHV1-14 Gene

pseudogene   GIFtS: 12

GC14M086743
immunoglobulin heavy variable 1-14 pseudogene
(Previous name: immunoglobulin heavy variable 1-14 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for IGHV1-14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
immunoglobulin heavy variable 1-14 pseudogene1 2
immunoglobulin heavy variable 1-141
1-14P2
IGHV1142

External Ids:    HGNC: 55471   Entrez Gene: 284702   

Export aliases for IGHV1-14 gene to outside databases

Previous GC identifers: GC14U990225 GC14M104574 GC14M105673 GC14M106603


Summaries
for IGHV1-14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGHV1-14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV1-14
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IGHV1-14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   HGNC cytogenetic band: 14q32.32-q32.33

IGHV1-14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGHV1-14 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M086743:  view genomic region     (about GC identifiers)

Start:
 86,743,342 bp from pter
End:
 86,743,591 bp from pter
Size:
 250 bases
Orientation:
 minus strand

1 alternative location:
Chr14- 106,602,571-106,602,820     

Proteins
for IGHV1-14 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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Human Recombinant Proteins 
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Assays for IGHV1-14: 
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Protein Domains/
Families
for IGHV1-14 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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   --

Gene Function
for IGHV1-14 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHV1-14 
Search SABiosciences for Assays for microRNAs that regulate IGHV1-14

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for IGHV1-14 


Pathways & Interactions
for IGHV1-14 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
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    SABiosciences Custom Pathway-Focused PCR Arrays for IGHV1-14 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV1-14

Drugs & Compounds
for IGHV1-14 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV1-14


Transcripts
for IGHV1-14 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
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Browse OriGene siRNA
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IGHV1-14 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGHV1-14 
Search SABiosciences for Assays for microRNAs that regulate IGHV1-14
Clones: Browse FLAG tag genes at Sigma-Aldrich
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
Browse 3'-UTR reporter clones for miRNA target validation 
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Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGHV1-14

highest scoring ESTs for IGHV1-14:

AW403330 BE155933 CV379192 AJ519282 AF471201 AF471499 AY339597 AB063870 AF471198 DQ431489 


GeneLoc Exon Structure


Expression
for IGHV1-14 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IGHV1-14 expression in normal and diseased human tissues

1  / 2  / 3

16 probe-sets matching IGHV1-14 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
211878_at*2, 3 U133-A 122 0.64 0.01 -- -- M26463 0.20 0.00 0.14 2
217384_x_at*2 U133-A 167 0.46 0.01 -- -- -- -- -- -- --
217198_x_at*2 U133-A 202 0.46 0.01 -- -- -- -- -- -- --
234419_x_at*2 U133-B 176 0.46 0.01 -- -- -- -- -- -- --
217360_x_at*2 U133-A 169 0.36 0.01 -- -- -- -- -- -- --
211638_at*2, 3 U133-A 158 0.36 0.01 -- -- L23517 0.20 0.00 0.14 2
211636_at*2 U133-A 145 0.27 0.01 -- -- -- -- -- -- --
217169_at*2 U133-A 124 0.27 0.01 -- -- -- -- -- -- --
211878_at*2 U133Plus2 122 0.64 0.01 -- -- -- -- -- -- --
217384_x_at*2 U133Plus2 167 0.46 0.01 -- -- -- -- -- -- --
217198_x_at*2 U133Plus2 202 0.46 0.01 -- -- -- -- -- -- --
234419_x_at*2 U133Plus2 176 0.46 0.01 -- -- -- -- -- -- --
217360_x_at*2 U133Plus2 169 0.36 0.01 -- -- -- -- -- -- --
211638_at*2 U133Plus2 158 0.36 0.01 -- -- -- -- -- -- --
211636_at*2 U133Plus2 145 0.27 0.01 -- -- -- -- -- -- --
217169_at*2 U133Plus2 124 0.27 0.01 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
IGHV1-14 gene expression
IGHV1-14 gene electronic northern expression
IGHV1-14 gene sage expression
About these images

CGAP SAGE TAG: --
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGHV1-14
    SABiosciences Custom PCR Arrays for IGHV1-14 


Orthologs
for IGHV1-14 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
   --

Paralogs
for IGHV1-14 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

Genomic Variants
for IGHV1-14 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
Search QIAGEN SeqTarget long-range PCR primers for resequencing for IGHV1-14 

Disorders & Mutations
for IGHV1-14 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for IGHV1-14 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for IGHV1-14 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

1 PubMed article for IGHV1-14 gene integrated from 7 sources:
(articles sorted by number of sources associating them with IGHV1-14)
  1. Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus. (PubMed id 8490662)1 Matsuda F....Anand R. (1993)

External Searches for IGHV1-14 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGHV1-14 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28470 HGNC: 5547 euGenes: HUgn28470 ECgene: IGHV1-14 H-InvDB: IGHV1-14

Other Databases showing IGHV1-14 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGHV1-14 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
IMGT entry for IGHV1-14 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGHV1-14 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for IGHV1-14 gene:
Search GeneIP for patents involving IGHV1-14

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGHV1-14 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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