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IGLV1-47 Gene

protein-coding   GIFtS: 21

GC22P022713
immunoglobulin lambda variable 1-47
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for IGLV1-47 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
immunoglobulin lambda variable 1-471 2
V1-172
IGLV1472

External Ids:    HGNC: 58801   Entrez Gene: 288222   Ensembl: ENSG000002116487   UniProtKB: A2MYD04   UniProtKB: Q8NEJ14   

Export aliases for IGLV1-47 gene to outside databases

Previous GC identifers: GC22U990174 GC22P021036 GC22P021042


Summaries
for IGLV1-47 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGLV1-47 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLV1-47
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IGLV1-47

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV1-47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV1-47 gene location

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022713:  view genomic region     (about GC identifiers)

Start:
 22,712,087 bp from pter
End:
 22,712,610 bp from pter
Size:
 524 bases
Orientation:
 plus strand

1 alternative location:
Chr22+ 5,670,621-5,671,088     

Proteins
for IGLV1-47 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/TrEMBL: A2MYD0 (See protein sequence)
Recommended Name: V1-17 protein  
Size: 99 amino acids; 10396 Da

UniProtKB/TrEMBL: Q8NEJ1 (See protein sequence)

Recommended Name: Putative uncharacterized protein  
Size: 236 amino acids; 25024 Da

Explore the universe of human proteins at neXtProt for IGLV1-47: NX_Q8NEJ1 



ENSEMBL proteins: 
ENSP00000374829 


Human Recombinant Proteins 
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Protein Domains/
Families
for IGLV1-47 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGLV1-47 for domains           About GeneDecksing

5/6 InterPro domains/families (see all 6):
 IPR007110 Ig-like
 IPR003006 Ig/MHC_CS
 IPR003596 Ig_V-set_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry A2MYD0
Graphical View of Domain Structure for InterPro Entry Q8NEJ1

ProtoNet protein and cluster: A2MYD0


Gene Function
for IGLV1-47 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGLV1-47 
Search SABiosciences for Assays for microRNAs that regulate IGLV1-47

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for IGLV1-47 


Pathways & Interactions
for IGLV1-47 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for IGLV1-47 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLV1-47

Drugs & Compounds
for IGLV1-47 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLV1-47


Transcripts
for IGLV1-47 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
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miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IGLV1-47 
Search SABiosciences for Assays for microRNAs that regulate IGLV1-47
Clones: Browse FLAG tag genes at Sigma-Aldrich
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Browse 3'-UTR reporter clones for miRNA target validation 
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Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGLV1-47

5 AceView cDNA sequences:

S63730 U09902 Z46312 AF047209 U09887 

highest scoring ESTs for IGLV1-47:

U36536 AB064170 AB064171 BM830690 BM830821 CD685161 CD694743 CD699950 CD706491 DQ098790 


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390294

Expression
for IGLV1-47 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

IGLV1-47 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching IGLV1-47 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
31459_i_at*2 U95-A 82 0.54 0.01 1.00 1.00 -- -- -- -- --
216430_x_at*2 U133-A 94 0.73 0.01 -- -- -- -- -- -- --
216430_x_at*2 U133Plus2 94 0.73 0.01 -- -- -- -- -- -- --
About this table

IGLV1-47 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
IGLV1-47 gene expression
IGLV1-47 gene electronic northern expression
IGLV1-47 gene sage expression
About these images

CGAP SAGE TAG: --
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for IGLV1-47
    SABiosciences Custom PCR Arrays for IGLV1-47 


Orthologs
for IGLV1-47 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
 ENSEMBL Gene Tree for IGLV1-47 (if available)

Paralogs
for IGLV1-47 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for IGLV1-47 gene
ENSG000002116602  IGLV2-182  IGLV1-502  IGLV1-402  ENSG000002116662  IGLV2-332  IGLV6-572  LOC1002904812  
IGLV1-362  ENSG000002116442  ENSG000002116712  ENSG000002116682  

IGLV1-47 for paralogs           About GeneDecksing



Genomic Variants
for IGLV1-47 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
Search QIAGEN SeqTarget long-range PCR primers for resequencing for IGLV1-47 

Disorders & Mutations
for IGLV1-47 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for IGLV1-47 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for IGLV1-47 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

2 PubMed articles for IGLV1-47 gene integrated from 7 sources:
(articles sorted by number of sources associating them with IGLV1-47)
  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K....Shimizu N. (1997)
  2. Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372)1 Williams S.C....Winter G. (1996)

External Searches for IGLV1-47 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLV1-47 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28822 HGNC: 5880 AceView: IGLV1-47 Ensembl:ENSG00000211648 euGenes: HUgn28822
ECgene: IGLV1-47 H-InvDB: IGLV1-47

Other Databases showing IGLV1-47 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLV1-47 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
IMGT entry for IGLV1-47 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGLV1-47 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for IGLV1-47 gene:
Search GeneIP for patents involving IGLV1-47

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGLV1-47 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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