Aliases &
Descriptions
for INSM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| insulinoma-associated 21 2 | | insulinoma-associated protein IA-62 | | IA-61 2 | | mlt12 | | Zinc finger protein IA-62 3 | | IA63 | | insulinoma-associated protein 22 | | |
Export aliases for INSM2 gene to outside databasesPrevious GC identifers: GC14P033381 GC14P029790 GC14P033993 GC14P035072 GC14P036003 |
Summaries
for INSM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92Function: May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity)
|
Genomic Views
for INSM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INSM2 gene promoter:
NF-kappaB1 CUTL1 CHOP-10 C/EBPalpha Chx10 NF-kappaB oct-B2 POU2F2B POU2F2C Oct-B1
Other transcription factors
Search SABiosciences Chromatin IP Primers for INSM2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for INSM2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q13.2 Ensembl cytogenetic band: 14q13.2 HGNC cytogenetic band: 14q13.1INSM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P016117: view genomic region
(about GC identifiers)
Start:
|
16,117,138 bp from pter |
End:
|
16,120,150 bp from pter |
Size:
|
3,013 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr14+ 36,003,248-36,006,260 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for INSM2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92 (See
protein sequence)Recommended Name: Insulinoma-associated protein 2 Size: 566 amino acids; 59491 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAK49393.1; Type=Frameshift; Positions=123, 127;
Secondary accessions: A1L432 Q8N8K7 Q96Q84Explore the universe of human proteins at neXtProt for INSM2: NX_Q96T92
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_115983.3
ENSEMBL proteins: ENSP00000306523
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
INSM2 for ontologies About GeneDecksing
Antibodies for INSM2:
Assays for INSM2: |
Protein
Domains/
Families
for INSM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INSM2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96T92ProtoNet protein and cluster: Q96T92 UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92Similarity: Contains 5 C2H2-type zinc fingers |
Gene Function
for INSM2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: INSM2_HUMAN, Q96T92Function: May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons (By similarity)
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
INSM2 for ontologies About GeneDecksing
|
Pathways & Interactions
for INSM2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for INSM2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INSM2
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045449 | regulation of transcription |
IEA | -- |
About this table
INSM2 for ontologies About GeneDecksing
|
Drugs & Compounds
for INSM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for INSM2
|
Transcripts
for INSM2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for INSM2 gene: NM_032594.3 Additional cDNA sequence: AB037912.1 AF260323.1 AK096639.1 BC130377.1 BC130379.1 1 DOTS entry: DT.40114524 16 AceView cDNA sequences: AW090356 BX394847 AW090573 AK096639 BX388388 NM_032594 AU252443 BE312386 AF260323 BG519620 AB037912 BX351134 AU252442 AW148539 AW149262 BF312968
 highest scoring ESTs for INSM2:AA046477 AA046951 AA058826 AB037912 AF260323 AK096639 AU252443 AW090356 AW090573 AW148539 Unigene Cluster for INSM2: Insulinoma-associated 2 Hs.62813 [show with all ESTs]Unigene Representative Sequence: AF260323
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000307169(uc001wth.1)
|
Expression
for INSM2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| INSM2 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching INSM2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 240841_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AA046951 |
0.80 |
1.00 |
0.91 |
1 |
| 240841_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCCATTCTTA
SOURCE GeneReport for Unigene cluster: Hs.62813
SABiosciences Custom PCR Arrays for INSM2
|
Orthologs
for INSM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for INSM2 gene from 5/6 species (see all 6)
About this table Species with no ortholog for INSM2
ENSEMBL Gene Tree for INSM2 (if available) |
Paralogs
for INSM2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for INSM2 gene
- INSM12
INSM2 for paralogs About GeneDecksing
|
Genomic Variants
for INSM2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 14 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for INSM2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for INSM2
1 CNV: 71885 | | QIAGEN SeqTarget long-range PCR primers for resequencing INSM2 |
|
Disorders & Mutations
for INSM2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for INSM2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for INSM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for INSM2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with INSM2)- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to selec t first-degree relatives of type 1 diabetic patients with risk of rapid progres sion to clinical onset of the disease: implications for prevention trials. (PubMed id 20091020)1 De Grijse J....Gorus F.K. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)2 Ohira M.... Nakagawara A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for INSM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INSM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INSM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INSM2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for INSM2 gene:
Search GeneIP for patents involving INSM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INSM2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for INSM2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for INSM2 |
| |
|
|
