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ISYNA1 Gene

protein-coding GIFtS: 53

GC19M018108

inositol-3-phosphate synthase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
inositol-3-phosphate synthase 1¹ ²		MIP synthase² ³
IPS¹ ² ⁵		hIPS² ³
INOS¹ ²		IPS 1² ³
Myo-inositol 1-phosphate synthase A1² ³		hINO1² ³
Myo-inositol-1-phosphate synthase² ³		Ino1¹
INO1² ³		EC 5.5.1.4³
MI-1-P synthase² ³

External Ids:	HGNC: 29821¹	Entrez Gene: 51477²	Ensembl: ENSG00000105655⁷	UniProtKB: Q9NPH2³

Export aliases for ISYNA1 gene to outside databases

Previous GC identifers: GC19M019039 GC19M018937 GC19M018390 GC19M018406 GC19M018545

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ISYNA1:

Myoinositol, the most common naturally occurring form of inositol, is a component of plasma membrane phospholipids and

functions as a cell signaling molecule. ISYNA1 (EC 5.5.1.4), or IPS, is a rate-limiting enzyme that catalyzes the de

novo synthesis of myoinositol 1-phosphate from glucose 6-phosphate (Seelan et al., 2004 (PubMed 15464731)).(supplied

by OMIM)

UniProtKB/Swiss-Prot: INO1_HUMAN, Q9NPH2

Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to

1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing

compounds

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ISYNA1 gene promoter:
         YY1   STAT3   RFX1   p300   E2F-1   E2F   E47   ZID   AhR   Arnt
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ISYNA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ISYNA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11

ISYNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISYNA1 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M018108: view genomic region (about GC identifiers)

Start:	18,108,499 bp from pter
End:	18,112,412 bp from pter
Size:	3,914 bases
Orientation:	minus strand

1 alternative location:

Chr19- 18,545,625-18,548,943

RefSeq DNA sequence:

NC_000019.9 NT_011295.11

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: INO1_HUMAN, Q9NPH2 (See protein sequence)

Recommended Name: Inositol-3-phosphate synthase 1

Size: 558 amino acids; 61068 Da

Cofactor: NAD

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAP97151.1; Type=Frameshift; Positions=82, 85, 496;

Secondary accessions: Q6NXT5 Q7Z525 Q9BT65 Q9H2Y2 Q9NSU0 Q9NVW7

Alternative splicing: 2 isoforms: Q9NPH2-1 Q9NPH2-2

Explore the universe of human proteins at neXtProt for ISYNA1: NX_Q9NPH2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001164409.1 NP_001164410.1 NP_057452.1

ENSEMBL proteins:

ENSP00000315147 ENSP00000337746 ENSP00000415458

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ISYNA1
	GenScript Custom Purified and Recombinant Proteins Services for ISYNA1
	Novus Biologicals Protein for ISYNA1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

About this table

ISYNA1 for ontologies About GeneDecksing

Antibodies for ISYNA1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ISYNA1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for ISYNA1
	Novus Biologicals Antibodies for ISYNA1
	Browse antibodies at Epitomics

Assays for ISYNA1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ISYNA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ISYNA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ISYNA1 for domains About GeneDecksing

3 InterPro domains/families:

IPR013021 Myo-inos-1-P_Synthase_GAPDH

IPR002587 Myo-inos-1-P_Synthase

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q9NPH2

ProtoNet protein and cluster: Q9NPH2

1 Blocks protein family: IPB002587 Myo-inositol-1-phosphate synthase

UniProtKB/Swiss-Prot: INO1_HUMAN, Q9NPH2

Similarity: Belongs to the myo-inositol-1-phosphate synthase family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: INO1_HUMAN, Q9NPH2

Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to

1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing

compounds

Catalytic activity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate

Enzyme regulation: Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium

Biophysicochemical properties: Kinetic parameters: KM=0.57 mM for 6-phosphate; KM=8 uM for NAD; pH dependence: Optimum

pH is 8.0;

Induction: By glucose and lovastain. Up-regulation is prevented by mevalonic acid, farnesol, and geranylgeraniol.

Up-regulated by E2F1

Enzyme Number (IUBMB): EC 5.5.1.4

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ISYNA1 Sigma-Aldrich shRNA for ISYNA1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ISYNA1 OriGene shRNA RFP (see all 4): ISYNA1 OriGene basic RS shRNA (see all 4): ISYNA1 OriGene siRNA (see all 3): ISYNA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISYNA1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISYNA1
		Search SABiosciences for Assays for microRNAs that regulate ISYNA1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ISYNA1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ISYNA1 OriGene untagged cDNA clones in CMV expression vector: ISYNA1 OriGene 3'-UTR clone: ISYNA1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ISYNA1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ISYNA1

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004512	inositol-3-phosphate synthase activity	IEA	--
GO:0005488	binding	IEA	--
GO:0016853	isomerase activity	IEA	--

About this table

ISYNA1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

ISYNA1 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for ISYNA1

Inositol Phosphate Metabolism

2 Kegg Pathways (Kegg details for ISYNA1):

	hsa00562 Inositol phosphate metabolism
	hsa01100 Metabolic pathways

UniProtKB/Swiss-Prot: INO1_HUMAN, Q9NPH2

Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2

    SABiosciences Custom Pathway-Focused PCR Arrays for ISYNA1

  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ISYNA1
  Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ISYNA1

5/9 Interacting proteins for ISYNA1 (Q9NPH2² ENSP00000315147³) via UniProtKB, MINT, and/or STRING (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2CA	P67775²	MINT-65632
IMPA1	ENSP00000256108³	STRING: ENSP00000256108
IMPA2	ENSP00000269159³	STRING: ENSP00000269159
GCK	ENSP00000223366³	STRING: ENSP00000223366
HK1	ENSP00000348697³	STRING: ENSP00000348697

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006021	inositol biosynthetic process	IEA	--
GO:0008654	phospholipid biosynthetic process	IEA	--

About this table

ISYNA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ISYNA1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ISYNA1 Sigma-Aldrich shRNA for ISYNA1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ISYNA1 OriGene shRNA RFP (see all 4): ISYNA1 OriGene basic RS shRNA (see all 4): ISYNA1 OriGene siRNA (see all 3): ISYNA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISYNA1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISYNA1
		Search SABiosciences for Assays for microRNAs that regulate ISYNA1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ISYNA1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ISYNA1 OriGene untagged cDNA clones in CMV expression vector: ISYNA1 OriGene 3'-UTR Clone: ISYNA1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ISYNA1

Primers:		OriGene genome-wide validated SYBR primer pairs: ISYNA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ISYNA1: PPH19187A

REFSEQ mRNAs for ISYNA1 gene (3 alternative transcripts):

NM_001170938.1 NM_001170939.1 NM_016368.4

Additional cDNA sequence:

AF086921.1 AF207640.1 AF220530.1 AK001325.1 AK021526.1 AK092179.1 AK093461.1 AK296022.1

AL137749.1 BC004320.1 BC018952.2 BC066902.1 CR599696.1 CR600268.1 CR606285.1 CR606341.1

24/25 DOTS entries (see all 25):

DT.85104226 DT.95278735 DT.91962553 DT.100881957 DT.91758900 DT.95278499 DT.95143351 DT.100881953

DT.95278725 DT.100881959 DT.121437702 DT.100038846 DT.121437722 DT.95244852 DT.100753340 DT.121437670

DT.437496 DT.95229283 DT.97862521 DT.100881961 DT.121437675 DT.121437680 DT.121437698 DT.95294902

24/324 AceView cDNA sequences (see all 324):

BG939449 AW195527 BU845065 CR606285 CD627838 CR599696 BI915609 BP373535

AK092433 BE645558 AX747545 AU119365 BQ002216 AK021526 BQ680494 CD722506

BQ576061 BP343122 BU844429 BM797041 BF116039 BU521220 CD243250 AI814293

highest scoring ESTs for ISYNA1:

AA216666 AF086921 AF207640 AF220530 AI625790 AI672316 AI817229 AK021526 AK092179 AK093461

Unigene Cluster for ISYNA1:

Inositol-3-phosphate synthase 1

Hs.405873 [show with all ESTs]

Unigene Representative Sequence: NM_016368

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ISYNA1 (see all 15)

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	·
SP1:																	-		-				-						-
SP2:													-		-		-		-				-						-
SP3:																							-						-
SP4:																	-		-
SP5:													-		-		-		-		-		-		-				-

ExUns:	11c	^	12a	·	12b	·	12c
SP1:	-
SP2:	-
SP3:	-
SP4:	-
SP5:

About this scheme

ECgene alternative splicing isoforms for ISYNA1
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000317018(uc002nja.1 uc002njb.1 uc002njc.1 uc002njd.1 uc010xqh.1 uc002nje.1 uc002njf.1)

ENST00000338128 ENST00000457269

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ISYNA1 expression in normal and diseased human tissues

¹ / ² / ³

7 probe-sets matching ISYNA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49690_at²^{, 3}	U95-C	1	1.00	1.00	0.84	1.26	AI817229	0.80	0.88	0.84	1
76665_at²^{, 3}	U95-E	1	0.75	1.00	0.98	0.76	AA216666	1.00	0.90	0.95	1
48092_at²^{, 3}	U95-B	1	0.50	1.00	0.33	1.00	AI739562	0.20	1.00	0.72	1
222240_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL137749	0.60	0.83	0.73	1
229324_x_at*²	U133-B	NULL	0.00	0.00	--	--	--	--	--	--	--
222240_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229324_x_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

ISYNA1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ISYNA1 gene electronic northern expression

About these images

CGAP SAGE TAG: CTCCTGGAAC

SOURCE GeneReport for Unigene cluster: Hs.405873

UniProtKB/Swiss-Prot: INO1_HUMAN, Q9NPH2

Tissue specificity: Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood

leukocyte, thymus, skeletal muscle and colon

Primers:		OriGene genome-wide validated SYBR primer pairs: ISYNA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ISYNA1: PPH19187A

SABiosciences Custom PCR Arrays for ISYNA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ISYNA1 gene from 5/22 species (see all 22)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ISYNA1¹	--	inositol-3-phosphate synthase 1	88.31(n) 92.81(a)	476667 XM_533872.2 XP_533872.2
chimpanzee (Pan troglodytes)	ISYNA1¹	--	inositol-3-phosphate synthase 1	99.58(n) 99.5(a)	455861 XM_512514.2 XP_512514.2
cow (Bos taurus)	ISYNA1¹	--	inositol-3-phosphate synthase 1	87.83(n) 92.63(a)	509394 NM_001046032.1 NP_001039497.1
rat (Rattus norvegicus)	Isyna1¹	--	inositol-3-phosphate synthase 1	81.66(n) 89.71(a)	290651 NM_001013880.1 NP_001013902.1
mouse (Mus musculus)	Isyna1^{1 , 5}	8 (34.15 cM)⁵	myo-inositol 1-phosphate synthase A1^{1, 5}	82.37(n)¹ 88.67(a)¹	71780¹ NM_023627.1¹ NP_076116.1¹ AF288525⁵ AI847162⁵ (see all 16)

About this table Species with no ortholog for ISYNA1

ENSEMBL Gene Tree for ISYNA1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs2303696^1,2	C,F	18548884(-)	`GGGGCA/GGGGAC`	2	--	int¹ ut5¹		7		EA NA	1232
rs2303697^1,2	C,F,A,	18546678(-)	`AACCTA/GTCGGC`	6	L	ref¹ syn¹ ese³		12		EA MN NA WA	2242
rs2385089^1,2	C,F,	18550434(+)	`taaaaC/Aaaaaa`	2	--	ng5¹		9		NS EA NA	494
rs2431132^1,2	--	18550897(+)	`agtgaA/Gccatg`	2	--	ng5¹		0	--	--	--	--
rs2434471^1,2	--	18550870(-)	`gagctC/Taagtg`	2	--	ng5¹		0	--	--	--	--
rs2434472^1,2	--	18550868(-)	`gctcaA/Ggtgat`	2	--	ng5¹		0	--	--	--	--
rs4595905^1,2	C,A,	18547305(+)	`GATGGA/TGAGGG`	2	--	int¹		3		NA WA	6
rs5827414^1,2	C	18550443(+)	`aaaaaA/-gccac`	2	--	ng5¹ trp³		1		NA	2
rs10413237^1,2	C,A,	18548249(+)	`TCCAGC/ACCCGG`	2	--	int¹		1		NA	2
rs10420384^1,2	C,F,A,	18549549(+)	`TGGGCC/GGGAGC`	2	--	ng5¹		13		NS EA NA WA	1042

About this table

HapMap Linkage Disequilibrium images for ISYNA1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ISYNA1: --

QIAGEN SeqTarget long-range PCR primers for resequencing ISYNA1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ISYNA1 for disorders About GeneDecksing

OMIM: 611670

Human Gene Mutation Database (HGMD): ISYNA1

Export disorders and mutations for ISYNA1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/12 PubMed articles for ISYNA1 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with ISYNA1)

Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast. (PubMed id 15024000)^{1, 2, 3} Ju S.... Greenberg M.L. (2004)
cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase. (PubMed id 12941308)^{1, 2, 3} Guan G....Shechter I. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter. (PubMed id 15464731)^{1, 2} Seelan R.S.... Parthasarathy R.N. (2004)
Human MIP synthase splice variants in bipolar disorder. (PubMed id 17988368)² Shamir A.... Agam G. (2007)
Effects of valproate derivatives on human brain myo-inositol-1- phosphate (MIP) synthase activity and amphetamine-induced rearing. (PubMed id 17901568)² Galit S.... Galila A. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent. (PubMed id 17121280)² Parthasarathy L.K....Parthasarathy R.N. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51477	HGNC: 29821	AceView: ISYNA1	Ensembl:ENSG00000105655	euGenes: HUgn51477
ECgene: ISYNA1	Kegg: 51477	H-InvDB: ISYNA1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for ISYNA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ISYNA1 gene:
Search GeneIP for patents involving ISYNA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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Search for Antibodies & Assays

	Regulatory tfbs in ISYNA1 promoter
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	SABiosciences Custom PCR Arrays for ISYNA1

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	Proteins for ISYNA1

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ELISAs and CLIAs for ISYNA1

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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protein-coding GIFtS: 53

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for ISYNA1 gene

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for ISYNA1 gene

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for ISYNA1 gene

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for ISYNA1 gene

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for ISYNA1 gene

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for ISYNA1 gene

Transcripts
for ISYNA1 gene

Expression
for ISYNA1 gene

Orthologs
for ISYNA1 gene

Paralogs
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Genomic Variants
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Publications
for ISYNA1 gene

Intellectual Property
for ISYNA1 gene

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