Aliases &
Descriptions
for MAP1LC3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| microtubule-associated protein 1 light chain 3 gamma1 2 3 | | MAP1 light chain 3-like protein 32 3 | | ATG8J1 2 | | LC3-like protein 22 | | Autophagy-related protein LC3 C2 3 | | MAP1 light chain 3-like protein 22 | | Autophagy-related ubiquitin-like modifier LC3 C2 3 | | microtubule-associated proteins 1A/1B light chain 3C2 | | MAP1A/MAP1B light chain 3 C2 3 | | LC3C2 | | MAP1A/MAP1B LC3 C2 3 | | |
Export aliases for MAP1LC3C gene to outside databasesPrevious GC identifers: GC01M238485 GC01M240225 GC01M242158 |
Summaries
for MAP1LC3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP1LC3C:
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance anddevelopment. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 (PubMed12740394)).(supplied by OMIM)
UniProtKB/Swiss-Prot: MLP3C_HUMAN, Q9BXW4Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity)
|
Genomic Views
for MAP1LC3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP1LC3C gene promoter:
MRF-2 LCR-F1 deltaCREB CREB NF-E2 NF-E2 p45 p53 c-Fos c-Jun Fra-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP1LC3C
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q43 Ensembl cytogenetic band: 1q43 HGNC cytogenetic band: 1q43MAP1LC3C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M212618: view genomic region
(about GC identifiers)
Start:
|
212,617,683 bp from pter |
End:
|
212,621,283 bp from pter |
Size:
|
3,601 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr1- 242,158,792-242,162,375 |
RefSeq DNA sequence:- NC_000001.10 NT_167186.1
|
Proteins
for MAP1LC3C gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: MLP3C_HUMAN, Q9BXW4 (See
protein sequence)Recommended Name: Microtubule-associated proteins 1A/1B light chain 3C precursor Size: 147 amino acids; 16852 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity)
Subcellular location: Cytoplasm. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane;Lipid-anchor. Note=LC3-II binds to the autophagic membranes
Secondary accessions: A0PJY8 A2RUP0Explore the universe of human proteins at neXtProt for MAP1LC3C: NX_Q9BXW4
Post-translational modifications:
The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7,transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II1
REFSEQ proteins: NP_001004343.1
ENSEMBL proteins: ENSP00000349785
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
MAP1LC3C for ontologies About GeneDecksing
Antibodies for MAP1LC3C:
Assays for MAP1LC3C: |
Protein
Domains/
Families
for MAP1LC3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP1LC3C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BXW4ProtoNet protein and cluster: Q9BXW4 1 Blocks protein family: IPB004241 Light chain 3 (LC3)
UniProtKB/Swiss-Prot: MLP3C_HUMAN, Q9BXW4Similarity: Belongs to the MAP1 LC3 family |
Gene Function
for MAP1LC3C gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: MLP3C_HUMAN, Q9BXW4Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity)
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
MAP1LC3C for ontologies About GeneDecksing
|
Pathways & Interactions
for MAP1LC3C gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for MAP1LC3C
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP1LC3C
2 Interacting proteins for MAP1LC3C (Q9BXW41) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006914 | autophagy |
IEA | -- |
About this table
MAP1LC3C for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP1LC3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MAP1LC3C
|
Transcripts
for MAP1LC3C gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for MAP1LC3C gene: NM_001004343.2 Additional cDNA sequence: AF276659.1 BC127722.1 BC132986.1 BC132988.1 2 DOTS entries: DT.95149060 DT.40261247 4 AceView cDNA sequences: NM_001004343 AF276659 BX282224 AA424268
 highest scoring ESTs for MAP1LC3C:AF276659 AA424268 BC127722 BX282224 CN260933 NM_001004343 Unigene Cluster for MAP1LC3C: Microtubule-associated protein 1 light chain 3 gamma Hs.534971 [show with all ESTs]Unigene Representative Sequence: NM_001004343
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000357246(uc001hzk.2)
|
Expression
for MAP1LC3C gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MAP1LC3C expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching MAP1LC3C gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 221697_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
AF276659 |
0.60 |
1.00 |
0.82 |
1 |
| 221697_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGGGCAGGTG
SOURCE GeneReport for Unigene cluster: Hs.534971
UniProtKB/Swiss-Prot: MLP3C_HUMAN, Q9BXW4Tissue specificity: Most abundant in placenta, lung and ovary
SABiosciences Custom PCR Arrays for MAP1LC3C
|
Orthologs
for MAP1LC3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAP1LC3C gene from 5 species
About this table Species with no ortholog for MAP1LC3C
ENSEMBL Gene Tree for MAP1LC3C (if available) |
Paralogs
for MAP1LC3C gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MAP1LC3C gene
- GABARAPL22 MAP1LC3B2 MAP1LC3A2 GABARAP2 GABARAPL32 MAP1LC3B22 GABARAPL12
MAP1LC3C for paralogs About GeneDecksing
|
Genomic Variants
for MAP1LC3C gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAP1LC3C
1 CNV: 8352 | | QIAGEN SeqTarget long-range PCR primers for resequencing MAP1LC3C |
|
Disorders & Mutations
for MAP1LC3C gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP1LC3C for disorders About GeneDecksing
OMIM: 609605
Export disorders and mutations for MAP1LC3C gene to outside databases
|
Medical News
for MAP1LC3C gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MAP1LC3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for MAP1LC3C gene integrated from 7 sources:
(articles sorted by number of sources associating them with MAP1LC3C)- Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PubMed id 12740394)1, 2, 3 He H.... Yu L. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. (PubMed id 15187094)1, 2 Tanida I....Kominami E. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. (PubMed id 19250911)1 Kirkin V.... Johansen T. (2009)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The cleavage of host cell proteins by HIV-1 protease. (PubMed id 8997639)1 Snasel J. and Pichova I. (1996)
- Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases. (PubMed id 2212989)1 Wallin M....Danielson U.H. (1990)
|
External Searches for MAP1LC3C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP1LC3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP1LC3C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP1LC3C gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAP1LC3C gene:
Search GeneIP for patents involving MAP1LC3C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP1LC3C gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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