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MARVELD2 Gene

protein-coding   GIFtS: 49

GC05P065667
MARVEL domain containing 2
(Previous names: MARVEL (membrane-associating) domain containing 2, deafness, autosomal recessive 49 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MRVLDC2, DFNB49)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
MARVEL domain containing 21 2     MARVEL domain-containing protein 22
TRIC1 3 5     OTTHUMP000002222252
FLJ305321 2     Tric2
MARVEL (membrane-associating) domain containing 21 2     MRVLDC22
DFNB492 5     tricellulin2
MARVD22 5     Tricellulin3
deafness, autosomal recessive 491     

External Ids:    HGNC: 264011   Entrez Gene: 1535622   Ensembl: ENSG000001529397   UniProtKB: Q8N4S93   

Export aliases for MARVELD2 gene to outside databases

Previous GC identifer: GC05P068746


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MARVELD2:
Tight junctions (TJ) prevent leakage of solutes through the paracellular pathway of epithelial cells. MARVELD2, or
tricellulin (TRIC), is an integral membrane protein concentrated at the vertically oriented TJ strands of tricellular
contacts (Ikenouchi et al., 2005 (PubMed 16365161)).(supplied by OMIM)

UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9
Function: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and
perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing

Gene Wiki entry for MARVELD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARVELD2 gene promoter:
         CUTL1   FAC1   POU2F1   HOXA9B   Meis-1   AREB6   MZF-1   ATF-2   Pax-5   POU3F2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MARVELD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.1

MARVELD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARVELD2 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P065667:  view genomic region     (about GC identifiers)

Start:
65,667,182 bp from pter
End:
65,694,144 bp from pter
Size:
26,963 bases
Orientation:
plus strand

2 alternative locations:
Chr5+,PATCHES 69,103,528-69,130,025      Chr5+ 68,710,939-68,740,157     
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9 (See protein sequence)
Recommended Name: MARVEL domain-containing protein 2  
Size: 558 amino acids; 64180 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction, tight junction (By similarity).
Note=Found at tricellular contacts (By similarity)
Secondary accessions: A1BQX0 A1BQX1 A8KA97 Q96NM9
Alternative splicing: 3 isoforms:  Q8N4S9-1   Q8N4S9-2   Q8N4S9-3   

Explore the universe of human proteins at neXtProt for MARVELD2: NX_Q8N4S9 

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001033692.2  

    ENSEMBL proteins: 
    ENSP00000282886 ENSP00000423490 ENSP00000323264 ENSP00000421902 ENSP00000396244 ENSP00000414776 
    ENSP00000398922 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MARVELD2
    OriGene Protein Over-expression Lysate: MARVELD2
    GenScript Custom Purified and Recombinant Proteins Services for MARVELD2 
    Novus Biologicals Lysate for MARVELD2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0005923 tight junction IEA--
    GO:0016021 integral to membrane IEA--
    GO:0030054 cell junction IEA--
    About this table

    MARVELD2 for ontologies           About GeneDecksing



    Antibodies for MARVELD2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse antibodies at Epitomics

    Assays for MARVELD2: 
    Browse Kits and Assays available from Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MARVELD2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR021128 MARVEL-like_dom
     IPR008253 Marvel
     IPR010844 Occludin_RNApol2_elong_fac_ELL

    Graphical View of Domain Structure for InterPro Entry Q8N4S9

    ProtoNet protein and cluster: Q8N4S9

    2 Blocks protein families:
    IPB008253 Marvel
    IPB010844 Occludin and RNA polymerase II elongation factor ELL


    UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9
    Similarity: Contains 1 MARVEL domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9
    Function: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and
    perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MARVELD2
    Sigma-Aldrich shRNA for MARVELD2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): MARVELD2
    OriGene shRNA RFP (see all 3): MARVELD2
    OriGene basic RS shRNA (see all 3): MARVELD2
    OriGene siRNA (see all 3): MARVELD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MARVELD2 
    miRNA:Sigma-Aldrich microRNA Mimics for MARVELD2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MARVELD2 
    Search SABiosciences for Assays for microRNAs that regulate MARVELD2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MARVELD2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MARVELD2
    OriGene untagged cDNA clones in CMV expression vector (see all 3): MARVELD2
    OriGene 3'-UTR clone: MARVELD2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: MARVELD2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MARVELD2 


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for MARVELD2 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARVELD2

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605 sensory perception of sound IEA--
    About this table

    MARVELD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARVELD2


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MARVELD2
    Sigma-Aldrich shRNA for MARVELD2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): MARVELD2
    OriGene shRNA RFP (see all 3): MARVELD2
    OriGene basic RS shRNA (see all 3): MARVELD2
    OriGene siRNA (see all 3): MARVELD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MARVELD2 
    miRNA: Sigma-Aldrich microRNA Mimics for MARVELD2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MARVELD2 
    Search SABiosciences for Assays for microRNAs that regulate MARVELD2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MARVELD2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MARVELD2
    OriGene untagged cDNA clones in CMV expression vector (see all 3): MARVELD2
    OriGene 3'-UTR Clone: MARVELD2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: MARVELD2 
    Primers: OriGene genome-wide validated SYBR primer pairs: MARVELD2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MARVELD2: PPH18956A

    REFSEQ mRNAs for MARVELD2 gene: 

    NM_001038603.2  

    Additional cDNA sequence: 

    AB219936.1 AB219937.1 AK055094.1 AK292962.1 BC033689.1 DQ682656.1 DQ682657.1 DQ682658.1 

    7 DOTS entries:

    DT.91756161  DT.109014  DT.406580  DT.120855077  DT.86858008  DT.91994457  DT.92050085 

    24/65 AceView cDNA sequences (see all 65):

    W38683 BQ023768 CB069146 AA902629 W44766 BE549594 AI023974 AI288538 
    BC033689 BM766345 AA524190 AA704297 CB069382 AI355645 AI052428 R71698 
    NM_144724 BE090154 BF222447 AI283471 AK055094 BE081398 BX092467 BG285087 

    highest scoring ESTs for MARVELD2:

    AA902629 AI140740 AI283471 AI288538 AI355645 AW948876 BC033689 BE090154 BF222447 BG285087 

    Unigene Cluster for MARVELD2:

    MARVEL domain containing 2
    Hs.726520  [show with all ESTs]
    Unigene Representative Sequence: AK055094


    GeneLoc Exon Structure

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282886 ENST00000512803 ENST00000325631(uc003jwq.2 uc010ixf.2)
    ENST00000515844 ENST00000454295(uc003jws.1) ENST00000436532 ENST00000413223(uc003jwr.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MARVELD2 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching MARVELD2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    42522_at2, 3 U95-B 1 0.88 1.00 1.00 1.00 N57927 0.60 1.00 0.82 1
    235955_at2, 3 U133-B 1 1.00 1.00 -- -- N57927 0.60 1.00 0.82 1
    235141_at2, 3 U133-B 1 0.46 1.00 -- -- AW009562 0.60 0.75 0.68 1
    235955_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    235141_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    MARVELD2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MARVELD2 gene expression
    MARVELD2 gene electronic northern expression
    MARVELD2 gene sage expression
    About these images

    CGAP SAGE TAG: AGGCCCCTTA

    SOURCE GeneReport for Unigene cluster: Hs.726520
    Primers: OriGene genome-wide validated SYBR primer pairs: MARVELD2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MARVELD2: PPH18956A
        SABiosciences Custom PCR Arrays for MARVELD2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MARVELD2 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MARVELD21   -- MARVEL domain containing 2 76.27(n)
    76.99(a)
    487240  XM_544368.2  XP_544368.2 
    chimpanzee
    (Pan troglodytes)
    MARVELD21   -- MARVEL domain containing 2 99.46(n)
    99.1(a)
    461831  XM_517724.2  XP_517724.2 
    cow
    (Bos taurus)
    MARVELD21   -- MARVEL domain containing 2 87.25(n)
    88.51(a)
    541110  XM_614589.3  XP_614589.3 
    rat
    (Rattus norvegicus)
    Marveld21   -- MARVEL domain containing 2 82.97(n)
    85.38(a)
    365657  XM_345145.3  XP_345146.3 
    mouse
    (Mus musculus)
    Marveld21 , 5 13 (53.23 cM)5
    MARVEL (membrane-associating) domain containing 21, 5 85.12(n)1
    88.38(a)1
    2185181  NM_001038602.21  NP_001033691.11 
     AA7597375  AB2199355  (see all 15)
    About this table        Species with no ortholog for MARVELD2

    ENSEMBL Gene Tree for MARVELD2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MARVELD2 gene
    ELL32  OCEL12  ELL22  ELL2  

    MARVELD2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/202 NCBI SNPs in MARVELD2 are shown (see all 202)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs2990721,2
    C,F,A,68730234(-) atcacT/Agctca 1 -- int15Minor allele frequency- A:0.50NA EA WA 214
    rs2990731,2
    C,F,A,H,68729682(-) GAATTA/GTCATC 1 -- int113Minor allele frequency- G:0.49NA EA WA 720
    rs2990741,2
    C,F,A,H68729412(-) ctactT/Cgggag 1 -- int14Minor allele frequency- C:0.38NA 8
    rs2990751,2
    C,F,A,H,68728544(-) GGGCCC/TCTCAA 1 -- int117Minor allele frequency- T:0.34EA NA MN NS 2630
    rs2990761,2
    C,H68727091(-) agtggT/Cgggcg 1 -- int14Minor allele frequency- C:0.38NA WA 8
    rs2990871,2
    C,F,A,H,68712772(+) ctcatC/Ttcact 1 -- int112Minor allele frequency- T:0.49NS EA NA WA 636
    rs2990881,2
    C,A68713660(+) acttgG/Cgaggc 1 -- int12Minor allele frequency- C:0.50NA 4
    rs2990891,2
    --68715626(+) TACGGA/CGGGTC 4 G ref1 syn1 ese30--------
    rs2990901,2
    C,F,A,H,68716463(+) TCATAG/AAAATC 1 -- int15Minor allele frequency- A:0.48NA EA WA 214
    rs2990911,2
    C,F,A,H,68716633(+) TTATTA/TTGTCT 1 -- int18Minor allele frequency- T:0.36NA EA 296
    About this table

    HapMap Linkage Disequilibrium images for MARVELD2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MARVELD2
         2 CNVs: 99169 0283
         2 Indels: 62384 46913

    QIAGEN SeqTarget long-range PCR primers for resequencing MARVELD2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MARVELD2 for disorders           About GeneDecksing

    OMIM: 610572   disorders: 610153  

    UniProtKB/Swiss-Prot: MALD2_HUMAN, Q8N4S9

  • Defects in MARVELD2 are the cause of deafness autosomal recessive type 49 (DFNB49) [MIM:610153]. DFNB49 is a
  • form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner
    ear, the nerve pathways to the brain, or the area of the brain that receives sound information

    Human Gene Mutation Database (HGMD): MARVELD2

    Export disorders and mutations for MARVELD2 gene to outside databases


    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/33 PubMed articles for MARVELD2 gene, integrated from 7 sources (see all 33):
    (articles sorted by number of sources associating them with MARVELD2)
    1. Tricellulin is a tight-junction protein necessary for hearing. (PubMed id 17186462)1, 2, 3, 7 Riazuddin S.... Friedman T.B. (2006)
    2. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. (PubMed id 16365161)1, 2, 7 Ikenouchi J.... Tsukita S. (2005)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)1, 2 Zhang Y.... White F.M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Tight junction-associated MARVEL proteins marveld3, t ricellulin, and occludin have distinct but overlapping functions. (PubMed id 20164257)1, 7 Raleigh D.R....Turner J.R. (2010)
    8. Tricellulin forms a barrier to macromolecules in tric ellular tight junctions without affecting ion permeability. (PubMed id 19535456)1, 7 Krug S.M....Fromm M. (2009)
    9. Expression and localization of tricellulin in human n asal epithelial cells in vivo and in vitro. (PubMed id 20033365)1, 7 Ohkuni T....Sawada N. (2009)
    10. Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. (PubMed id 18084694)1, 7 Chishti M.S....Ahmad W. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 153562 HGNC: 26401 AceView: MARVELD2 Ensembl:ENSG00000152939 euGenes: HUgn153562
    ECgene: MARVELD2 H-InvDB: MARVELD2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for MARVELD2 gene:
    Search GeneIP for patents involving MARVELD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for MARVELD2 Browse antibodies at Sigma-Aldrich
     Super-pooled esiRNAs for MARVELD2 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MARVELD2 microRNA Mimics for MARVELD2
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    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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