Aliases &
Descriptions
for MIR2861 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| microRNA 28611 2 | | EC 2.7.11.223 | | MIRN28612 5 | | CDC2L43 | | BMND152 5 | | Cell division cycle 2-like protein kinase 43 | | hsa-mir-28611 | | Serine/threonine-protein kinase PITALRE3 | | EC 2.7.11.233 | | C-2K3 | | Cyclin-dependent kinase 93 | | |
Export aliases for MIR2861 gene to outside databasesPrevious GC identifer: GC09U901547 |
Summaries
for MIR2861 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR2861:
MicroRNAs, such as MIR2861, are single-stranded noncoding RNAs of about 22 nucleotides that negatively regulatetranslation by base pairing with partially or fully complementary sequences in target mRNAs. MIR2861 is involved inregulation of osteoblast differentiation (Li et al., 2009 (PubMed 19920351)).(supplied by OMIM)
UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750Function: Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcriptionelongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation byphosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. TheCDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro
|
Genomic Views
for MIR2861 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR2861
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR2861
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 9q34.11 HGNC chromosome: 9MIR2861 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P130548: view genomic region
(about GC identifiers)
Start:
|
130,547,958 bp from pter |
End:
|
130,553,066 bp from pter |
Size:
|
5,109 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr9+ 100,164,466-100,164,555 |
|
Proteins
for MIR2861 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750 (See
protein sequence)Recommended Name: Cell division protein kinase 9 Size: 372 amino acids; 42778 Da
Subunit: Associates with CCNT1/cyclin-T1 to form P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Also associates withCCNK/cyclin-K. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II,SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 andCCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs
Subcellular location: Nucleus
Sequence caution: Sequence=CAI39767.1; Type=Erroneous gene model prediction;
PDB structures from  and Proteopedia  :1PF6 (3D)
3BLH (3D)
3BLQ (3D)
3BLR (3D)
3MI9 (3D)
3MIA (3D)
Secondary accessions: Q5JU24 Q5JU25 Q5U006 Q96TF1Alternative splicing: 2 isoforms: P50750-1 P50750-2 Explore the universe of human proteins at neXtProt for MIR2861: NX_P50750
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
ENSEMBL proteins: ENSP00000362362 ENSP00000395872 ENSP00000362361
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
-- | -- | | GO:0005654 | nucleoplasm |
-- | -- | | GO:0008023 | transcription elongation factor complex |
-- | -- | | GO:0043231 | intracellular membrane-bounded organelle |
-- | -- |
About this table
MIR2861 for ontologies About GeneDecksing
Antibodies for MIR2861:
Assays for MIR2861: |
Protein
Domains/
Families
for MIR2861 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MIR2861 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P50750ProtoNet protein and cluster: P50750 UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Gene Function
for MIR2861 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750Function: Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcriptionelongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation byphosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. TheCDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitroCatalytic activity: ATP + a protein = ADP + a phosphoproteinCatalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphateEnzyme Numbers (IUBMB): EC 2.7.11.22 EC 2.7.11.23
5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
-- | -- | | GO:0003677 | DNA binding |
-- | -- | | GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
-- | -- | | GO:0004693 | cyclin-dependent protein kinase activity |
-- | -- |
About this table
MIR2861 for ontologies About GeneDecksing
|
Pathways & Interactions
for MIR2861 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for MIR2861
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR2861
5/810 Interacting proteins for MIR2861 (ENSP000003623623 P507502) via UniProtKB, MINT, and/or STRING (see all 810)About this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006367 | transcription initiation from RNA polymerase II promoter |
-- | -- | | GO:0006368 | RNA elongation from RNA polymerase II promoter |
-- | -- | | GO:0006468 | protein phosphorylation |
-- | -- | | GO:0008283 | cell proliferation |
-- | -- | | GO:0045449 | regulation of transcription |
-- | -- |
About this table
MIR2861 for ontologies About GeneDecksing
|
Drugs & Compounds
for MIR2861 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MIR2861
|
Transcripts
for MIR2861 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
GeneLoc Exon Structure
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000480353 ENST00000373265(uc004bse.2) ENST00000421939 ENST00000498339
ENST00000496284 ENST00000491521 ENST00000373264
|
Expression
for MIR2861 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MIR2861 expression in normal and diseased human tissues
Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: CDK9_HUMAN, P50750Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for MIR2861
|
Orthologs
for MIR2861 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MIR2861 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
baker's yeast
(Saccharomyces cerevisiae) |
SGV1(YPR161C)4 |
16(866418-864445) |
Cyclin (Bur2p)-dependent protein kinase that functions more |
-- |
856290 NP_015487.1 |
About this table Species with no ortholog for MIR2861
ENSEMBL Gene Tree for MIR2861 (if available) |
Paralogs
for MIR2861 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MIR2861 gene
- CDK122 CDK132
MIR2861 for paralogs About GeneDecksing
|
Genomic Variants
for MIR2861 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| |
Disorders & Mutations
for MIR2861 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MIR2861 for disorders About GeneDecksing
OMIM: 613405 disorders: 613418 Human Gene Mutation Database (HGMD): MIR2861
Export disorders and mutations for MIR2861 gene to outside databases
|
Medical News
for MIR2861 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MIR2861 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for MIR2861 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with MIR2861)- A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. (PubMed id 19920351)1 Li H....Luo X.H. (2009)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)2 Jeronimo C.... Coulombe B. (2007)
- Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)2 Wissing J.... Daub H. (2007)
- miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (2006)
- Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element. (PubMed id 14701750)2 Fujinaga K.... Peterlin B.M. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for MIR2861 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MIR2861 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MIR2861 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR2861 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/cdk9/ |
|
| | |
About This Section
| Patent Information for MIR2861 gene:
Search GeneIP for patents involving MIR2861
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR2861 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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