Aliases &
Descriptions
for MT-ATP8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| mitochondrially encoded ATP synthase 81 | | ATPase82 | | ATP81 2 3 | | ATP synthase F0 subunit 82 | | A6L1 3 | | F-ATPase subunit 83 | | MTATP82 3 | | ATPASE83 | | ATP synthase 81 | | |
Export aliases for MT-ATP8 gene to outside databasesPrevious GC identifer: GC00U921583 |
Summaries
for MT-ATP8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of therespiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalyticcore and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalksubunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in themembrane (By similarity)
Gene Wiki entry for MT-ATP8 |
Genomic Views
for MT-ATP8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MT-ATP8
Other transcription factors
Search SABiosciences Chromatin IP Primers for MT-ATP8
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Chromosome:MT
HGNC chromosome: mitochondriaGeneLoc gene densities for chromosome MT GeneLoc Exon Structure GeneLoc location for GCMTP008368: view genomic region
(about GC identifiers)
Start:
|
8,366 bp from pter |
End:
|
8,572 bp from pter |
Size:
|
207 bases |
Orientation:
|
minus strand |
|
Proteins
for MT-ATP8 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928 (See
protein sequence)Recommended Name: ATP synthase protein 8 Size: 68 amino acids; 7992 Da
Subunit: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel (Bysimilarity)
Subcellular location: Mitochondrion membrane; Single-pass membrane protein
Secondary accessions: Q34771Explore the universe of human proteins at neXtProt for MT-ATP8: NX_P03928
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
ENSEMBL proteins: ENSP00000355265
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
MT-ATP8 for ontologies About GeneDecksing
Antibodies for MT-ATP8:
Assays for MT-ATP8: |
Protein
Domains/
Families
for MT-ATP8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MT-ATP8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P03928ProtoNet protein and cluster: P03928 1 Blocks protein family: IPB001421 Mitochondrial ATPase
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928Similarity: Belongs to the ATPase protein 8 family |
Gene Function
for MT-ATP8 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ATP8_HUMAN, P03928Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in thepresence of a proton gradient across the membrane which is generated by electron transport complexes of therespiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalyticcore and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalksubunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in themembrane (By similarity)
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
MT-ATP8 for ontologies About GeneDecksing
|
Pathways & Interactions
for MT-ATP8 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
MT-ATP8 for pathways About GeneDecksing
5  Kegg Pathways (Kegg details for MT-ATP8):
SABiosciences Custom Pathway-Focused PCR Arrays for MT-ATP8
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-ATP8
5/20 Interacting proteins for MT-ATP8 (ENSP000003552653) via UniProtKB, MINT, and/or STRING (see all 20)About this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0015986 | ATP synthesis coupled proton transport |
NAS | -- | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0042776 | mitochondrial ATP synthesis coupled proton transport |
TAS | -- | | GO:0055093 | response to hyperoxia |
IEA | -- |
About this table
MT-ATP8 for ontologies About GeneDecksing
|
Drugs & Compounds
for MT-ATP8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
MT-ATP8 for compounds About GeneDecksing
 Browse Tocris compounds for MT-ATP8
2  Novoseek chemical compound relationships for MT-ATP8 gene
About this table
|
Transcripts
for MT-ATP8 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000361851
|
Expression
for MT-ATP8 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MT-ATP8 expression in normal and diseased human tissues
Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SABiosciences Custom PCR Arrays for MT-ATP8
|
Orthologs
for MT-ATP8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MT-ATP8 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
ATP81 |
-- |
ATP synthase F0 subunit 8 |
91.18(n)
92.65(a) |
807862 ATP8_5835123 NP_008190.1 |
About this table Species with no ortholog for MT-ATP8
ENSEMBL Gene Tree for MT-ATP8 (if available) |
Paralogs
for MT-ATP8 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for MT-ATP8 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| |
Disorders & Mutations
for MT-ATP8 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MT-ATP8 for disorders About GeneDecksing
OMIM: 516070
Human Gene Mutation Database (HGMD): MT-ATP8
Genetic Association Database (GAD): MT-ATP8
Export disorders and mutations for MT-ATP8 gene to outside databases
|
Medical News
for MT-ATP8 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MT-ATP8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/41 PubMed articles for MT-ATP8 gene, integrated from 7 sources (see all 41):
(articles sorted by number of sources associating them with MT-ATP8)- Polymorphisms in the coding region of mtDNA and effects on clinical outcome of unrelated bone marrow transplantation. (PubMed id 11607774)1, 4 Ishikawa Y....Juji T. (2001)
- Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (1981)
- Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PubMed id 17619138)1, 7 Ahari S.E....Bahar M.A. (2007)
- Mitochondrial tRNALeu/Lys and ATPase 6/8 gene variations in spinocerebellar ataxias. (PubMed id 19066432)1, 7 Safaei S....Shariati P. (2009)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- MtSNPscore: a combined evidence approach for assessin g cumulative impact of mitochondrial variations in disease. (PubMed id 19758471)1 Bhardwaj A....Tiwari S. (2009)
- Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians. (PubMed id 14760490)2 Coble M.D.... Parsons T.J. (2004)
- Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. (PubMed id 12840039)2 Ingman M. and Gyllensten U. (2003)
- Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J. (PubMed id 12949126)2 Moilanen J.S.... Majamaa K. (2003)
|
External Searches for MT-ATP8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MT-ATP8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MT-ATP8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MT-ATP8 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MT-ATP8 gene:
Search GeneIP for patents involving MT-ATP8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MT-ATP8 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for MT-ATP8 |
| |  |  |  |  | | | | |
 | | |
|
|
