Aliases &
Descriptions
for PADI1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| peptidyl arginine deiminase, type I1 2 | | Peptidylarginine deiminase I2 3 | | PDI11 2 3 | | Protein-arginine deiminase type I2 3 | | HPAD101 2 | | hPAD-colony 102 | | PAD11 2 | | protein-arginine deiminase type-12 | | PDI1 2 | | EC 3.5.3.153 |
Export aliases for PADI1 gene to outside databasesPrevious GC identifers: GC01P017269 GC01P016572 GC01P016912 GC01P017276 GC01P017404 GC01P017531 |
Summaries
for PADI1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PADI1:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translationaldeimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The familymembers have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involvedin the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintainshydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hairfollicle formation. This gene exists in a cluster with four other paralogous genes. (provided by RefSeq)
UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Function: Catalyzes the deimination of arginine residues of proteins (By similarity)
Gene Wiki entry for PADI1 |
Genomic Views
for PADI1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PADI1 gene promoter:
Sp1 LCR-F1 FAC1 GATA-1 GATA-3 GATA-2 LUN-1 AP-4 RORalpha2 C/EBPbeta
Other transcription factors
Search SABiosciences Chromatin IP Primers for PADI1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13PADI1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P015775: view genomic region
(about GC identifiers)
Start:
|
15,775,640 bp from pter |
End:
|
15,816,163 bp from pter |
Size:
|
40,524 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 17,531,621-17,572,501 |
RefSeq DNA sequence:- NC_000001.10 NT_004610.19
|
Proteins
for PADI1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6 (See
protein sequence)Recommended Name: Protein-arginine deiminase type-1 Size: 663 amino acids; 74666 Da
Cofactor: Calcium (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: A1L4K6 Q70SX6Explore the universe of human proteins at neXtProt for PADI1: NX_Q9ULC6
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_037490.2
ENSEMBL proteins: ENSP00000396697 ENSP00000364620
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
About this table
PADI1 for ontologies About GeneDecksing
Antibodies for PADI1:
Assays for PADI1: |
Protein
Domains/
Families
for PADI1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PADI1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9ULC6ProtoNet protein and cluster: Q9ULC6 1 Blocks protein family: IPB004303 Protein-arginine deiminase
UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Similarity: Belongs to the protein arginine deiminase family |
Gene Function
for PADI1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Function: Catalyzes the deimination of arginine residues of proteins (By similarity)Catalytic activity: Protein L-arginine + H(2)O = protein L-citrulline + NH(3)Enzyme Number (IUBMB): EC 3.5.3.15
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004668 | protein-arginine deiminase activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- |
About this table
PADI1 for ontologies About GeneDecksing
|
Pathways & Interactions
for PADI1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PADI1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PADI1
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | protein modification process |
IEA | -- | | GO:0018101 | peptidyl-citrulline biosynthetic process from peptidyl-arginine |
IEA | -- |
About this table
PADI1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PADI1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PADI1
|
Transcripts
for PADI1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PADI1 gene: NM_013358.2 Additional cDNA sequence: AB033768.2 AK026652.1 AK225541.1 AK293275.1 AK298538.1 AK298892.1 AK309106.1 AK314644.1 BC130574.1 BC136402.1 4 DOTS entries: DT.204987 DT.121405147 DT.101976294 DT.95127162 22 AceView cDNA sequences: AI378607 AW192295 BX284037 AI367538 AK127515 AL698692 BQ641703 AA495868 AB033768 BM050686 BM008704 AA912338 AI685069 BG680542 AK026652 AI738723 BM781897 BF509503 AI126015 NM_013358 AI129820 BF757553
 highest scoring ESTs for PADI1:AI685069 AA495868 AA912338 AB033768 AI126015 AI129820 AI367538 AI378607 AK026652 AW192295 Unigene Cluster for PADI1: Peptidyl arginine deiminase, type I Hs.412941 [show with all ESTs]Unigene Representative Sequence: AK026652
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PADI1 (see all 6)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · | 18b |
|---|
|
| SP1: | | | - | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PADI1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000413717(uc010ocp.1) ENST00000460293(uc009vpb.1) ENST00000375471(uc001bah.1 uc010oco.1 uc010ocq.1)
ENST00000483501
|
Expression
for PADI1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PADI1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching PADI1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 81926_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
1.00 |
1.00 |
AI685069 |
1.00 |
1.00 |
1.00 |
1 |
| 220962_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_013358 |
0.60 |
1.00 |
0.82 |
1 |
| 223739_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AK026652 |
0.80 |
1.00 |
0.91 |
1 |
| 220962_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223739_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PADI1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CATTTCTTAA
SOURCE GeneReport for Unigene cluster: Hs.412941
UniProtKB/Swiss-Prot: PADI1_HUMAN, Q9ULC6Tissue specificity: Epidermis, prostate, testis, placenta, spleen and thymus
SABiosciences Custom PCR Arrays for PADI1
|
Orthologs
for PADI1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PADI1 gene from 5 species
About this table Species with no ortholog for PADI1
ENSEMBL Gene Tree for PADI1 (if available) |
Paralogs
for PADI1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PADI1 gene
- PADI22 PADI42 PADI32
PADI1 for paralogs About GeneDecksing
|
Genomic Variants
for PADI1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PADI1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PADI1
1 CNV: 5200
1 Indel: 24005 | | QIAGEN SeqTarget long-range PCR primers for resequencing PADI1 |
|
Disorders & Mutations
for PADI1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PADI1 for disorders About GeneDecksing
OMIM: 607934
Export disorders and mutations for PADI1 gene to outside databases
|
Medical News
for PADI1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PADI1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/20 PubMed articles for PADI1 gene, integrated from 7 sources (see all 20):
(articles sorted by number of sources associating them with PADI1)- cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. (PubMed id 12416996)1, 2, 3, 7 Guerrin M.... Serre G. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. (PubMed id 15087120)1, 2 Chavanas S.... Simon M. (2004)
- Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes. (PubMed id 17851584)1, 7 Dong S....Takahara H. (2008)
- Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. (PubMed id 18669583)1, 7 Chen C....Zhao L.P. (2008)
- An intronic enhancer driven by NF-I_B contributes to t ranscriptional regulation of peptidylarginine deiminase type I gene in human ke ratinocytes. (PubMed id 20596086)1 Ying S....Takahara H. (2010)
- Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. (PubMed id 18710930)1 Proost P....Van Damme J. (2008)
- Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis. (PubMed id 16973334)1 Chavanas S....Simon M. (2006)
- The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations. (PubMed id 16091842)1 Mechin M.C....Simon M. (2005)
- Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin. (PubMed id 15675958)1 Nachat R....Simon M. (2005)
|
External Searches for PADI1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PADI1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PADI1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PADI1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PADI1 gene:
Search GeneIP for patents involving PADI1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PADI1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for PADI1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for PADI1 |
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