Aliases &
Descriptions
for PEX11B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| peroxisomal biogenesis factor 11 beta1 2 | | peroxisomal membrane protein 11B2 | | Peroxisomal biogenesis factor 11B1 2 3 | | peroxin-11B2 | | Protein PEX11 homolog beta2 3 | | Peroxin-11B3 | | PEX11-BETA2 | | PEX11-beta3 |
Export aliases for PEX11B gene to outside databasesPrevious GC identifers: GC01P144036 GC01P142103 GC01P143243 GC01P143265 GC01P143005 GC01P144227 GC01P145516 |
Summaries
for PEX11B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PX11B_HUMAN, O96011Function: Involved in peroxisomal proliferation. May regulate peroxisomes division by recruiting the dynamin-relatedGTPase DNM1L to the peroxisomal membrane
Gene Wiki entry for PEX11B |
Genomic Views
for PEX11B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PEX11B gene promoter:
Sox9 HOXA9B Meis-1 AP-2alphaA c-Myb Pax-6 Pax-2 POU3F1 RSRFC4 JunB
Other transcription factors
Search SABiosciences Chromatin IP Primers for PEX11B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PEX11B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21PEX11B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P119479: view genomic region
(about GC identifiers)
Start:
|
119,479,859 bp from pter |
End:
|
119,487,437 bp from pter |
Size:
|
7,579 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 145,516,252-145,523,730 |
RefSeq DNA sequence:- NC_000001.10 NT_167185.1
|
Proteins
for PEX11B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PX11B_HUMAN, O96011 (See
protein sequence)Recommended Name: Peroxisomal membrane protein 11B Size: 259 amino acids; 28431 Da
Subunit: Interacts with PEX19
Subcellular location: Peroxisome membrane; Single-pass membrane protein
Caution: PubMed:9792670 states that both the N- and the C-terminus are located in the cytoplasm
Secondary accessions: B3KN85 Q96ET2Explore the universe of human proteins at neXtProt for PEX11B: NX_O96011
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001171724.1 NP_003837.1
ENSEMBL proteins: ENSP00000358312 ENSP00000414018
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
PEX11B for ontologies About GeneDecksing
Antibodies for PEX11B:
Assays for PEX11B: |
Protein
Domains/
Families
for PEX11B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PEX11B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O96011ProtoNet protein and cluster: O96011 1 Blocks protein family: IPB008733 Peroxisomal biogenesis factor 11
UniProtKB/Swiss-Prot: PX11B_HUMAN, O96011Similarity: Belongs to the peroxin-11 family |
Gene Function
for PEX11B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PX11B_HUMAN, O96011Function: Involved in peroxisomal proliferation. May regulate peroxisomes division by recruiting the dynamin-relatedGTPase DNM1L to the peroxisomal membrane
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
PEX11B for ontologies About GeneDecksing
Animal Models: 9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pex11b):
PEX11B for phenotypes About GeneDecksing
|
Pathways & Interactions
for PEX11B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PEX11B for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for PEX11B):
SABiosciences Custom Pathway-Focused PCR Arrays for PEX11B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PEX11B
5/13 Interacting proteins for PEX11B (ENSP000003583123 O960112) via UniProtKB, MINT, and/or STRING (see all 13)About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007031 | peroxisome organization |
ISS | -- | | GO:0007165 | signal transduction |
ISS | -- | | GO:0016559 | peroxisome fission |
IEA | -- |
About this table
PEX11B for ontologies About GeneDecksing
|
Drugs & Compounds
for PEX11B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PEX11B
|
Transcripts
for PEX11B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PEX11B gene (2 alternative transcripts): NM_001184795.1 NM_003846.2 Additional cDNA sequence: AB018080.1 AF093670.1 AK023991.1 AK094173.1 AK301983.1 BC011963.1 CR542047.1 CR608642.1 12 DOTS entries: DT.121360180 DT.413896 DT.100781199 DT.100669469 DT.95252936 DT.121360157 DT.95080725 DT.100737599 DT.121360182 DT.121360251 DT.91754071 DT.95282601 24/710 AceView cDNA sequences (see all 710): BM504213 AW732552 BQ374198 BQ690177 BI859733 AI246134 CK905487 BM713606 BU784319 AA478530 BU782007 CA412548 BU190733 BQ374220 AA443427 CB155528 BM462398 BF373436 BM831104 BE256827 BQ374226 CA867805 BQ374179 NM_003846
 highest scoring ESTs for PEX11B:AF093670 AA037657 AA069866 AA071180 AA203743 AA321703 AA350944 AA350945 AA515589 AA700391 Unigene Cluster for PEX11B: Peroxisomal biogenesis factor 11 beta Hs.714608 [show with all ESTs]Unigene Representative Sequence: AK094173
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PEX11B (see all 7)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PEX11B
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369306(uc001eny.1 uc010oyu.1) ENST00000428634
|
Expression
for PEX11B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PEX11B expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching PEX11B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37900_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AF093670 |
1.00 |
1.00 |
1.00 |
1 |
| 202658_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_003846 |
0.60 |
1.00 |
0.82 |
1 |
| 202658_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PEX11B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGCCAGCCTC
SOURCE GeneReport for Unigene cluster: Hs.714608
Expression variation in blood from EXPOLDB for PEX11B SABiosciences Custom PCR Arrays for PEX11B
|
Orthologs
for PEX11B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PEX11B gene from 5/9 species (see all 9)
About this table Species with no ortholog for PEX11B
ENSEMBL Gene Tree for PEX11B (if available) |
Paralogs
for PEX11B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PEX11B gene
- PEX11A2
PEX11B for paralogs About GeneDecksing
|
Genomic Variants
for PEX11B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PEX11B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PEX11B
3 CNVs: 2324 5199 53561 | | QIAGEN SeqTarget long-range PCR primers for resequencing PEX11B |
|
Disorders & Mutations
for PEX11B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PEX11B for disorders About GeneDecksing
OMIM: 603867
Human Genome Epidemiology (HuGE) Navigator: PEX11B (1 document)
Export disorders and mutations for PEX11B gene to outside databases
|
Medical News
for PEX11B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PEX11B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/19 PubMed articles for PEX11B gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with PEX11B)- Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. (PubMed id 9792670)1, 2, 3 Schrader M.... Gould S.J. (1998)
- cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p. (PubMed id 9826565)1, 2, 7 Abe I. and Fujiki Y. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. (PubMed id 12618434)1, 2 Li X. and Gould S.J. (2003)
- PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. (PubMed id 10704444)1, 2 Sacksteder K.A.... Gould S.J. (2000)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance. (PubMed id 20826455)1 Koch J....Brocard C. (2010 Oct 1)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Peroxisomes in airway epithelia and future prospects of these organelles for pulmonary cell biology. (PubMed id 19229552)1 Karnati S. and Baumgart-Vogt E. (2009)
|
External Searches for PEX11B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PEX11B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PEX11B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PEX11B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PEX11B gene:
Search GeneIP for patents involving PEX11B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PEX11B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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