Aliases &
Descriptions
for PHF20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| PHD finger protein 201 2 | | C20orf1042 3 | | Novel zinc finger protein2 3 | | GLEA22 3 | | Hepatocellular carcinoma-associated antigen 582 3 | | HCA582 3 | | Glioma-expressed antigen 22 3 | | chromosome 20 open reading frame 1041 | | Transcription factor TZP2 3 | | dJ1121G12.11 | | NZF2 3 | | FLJ334792 | | TZP2 3 | | |
Export aliases for PHF20 gene to outside databasesPrevious GC identifers: GC20P033824 GC20P034359 |
Summaries
for PHF20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0Function: Possible transcription factor
Gene Wiki entry for PHF20 |
Genomic Views
for PHF20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PHF20 gene promoter:
Egr-1 NF-kappaB1 NF-kappaB Nkx6-1 TBP FOXD3 AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PHF20
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.22-q11.23 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.22-q11.23PHF20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P031137: view genomic region
(about GC identifiers)
Start:
|
31,137,752 bp from pter |
End:
|
31,316,089 bp from pter |
Size:
|
178,338 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr20+ 34,359,896-34,538,303 |
RefSeq DNA sequence:- NC_000020.10 NT_011362.10
|
Proteins
for PHF20 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0 (See
protein sequence)Recommended Name: PHD finger protein 20 Size: 1012 amino acids; 115386 Da
Subunit: Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 andRBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA,MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10
Subcellular location: Nucleus (Probable)
Miscellaneous: Antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastomaand childhood medulloblastula
Sequence caution: Sequence=AAF34184.1; Type=Frameshift; Positions=260; Sequence=AAK19748.1; Type=Frameshift;Positions=635, 653, 655;
Secondary accessions: A7E235 B2RB56 Q5JWY9 Q9BWV4 Q9BXA3 Q9BZW3 Q9H421 Q9H4J6 Q9NZ22Alternative splicing: 2 isoforms: Q9BVI0-1 Q9BVI0-2 Explore the universe of human proteins at neXtProt for PHF20: NX_Q9BVI0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057520.2
ENSEMBL proteins: ENSP00000363106 ENSP00000391915 ENSP00000363112 ENSP00000410373 ENSP00000404455 ENSP00000341900 ENSP00000400139 ENSP00000363124 ENSP00000413712
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PHF20 for ontologies About GeneDecksing
Antibodies for PHF20:
Assays for PHF20: |
Protein
Domains/
Families
for PHF20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PHF20 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q9BVI0ProtoNet protein and cluster: Q9BVI0 2 Blocks protein families: IPB001965 Zn-finger-like IPB002999 Tudor domain
UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0Similarity: Contains 1 A.T hook DNA-binding domainSimilarity: Contains 1 C2H2-type zinc fingerSimilarity: Contains 1 PHD-type zinc finger |
Gene Function
for PHF20 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0Function: Possible transcription factor
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PHF20 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Phf20):
PHF20 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PHF20 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PHF20
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHF20
5/26 Interacting proteins for PHF20 (Q9BVI02) via UniProtKB, MINT, and/or STRING (see all 26)About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045449 | regulation of transcription |
IEA | -- |
About this table
PHF20 for ontologies About GeneDecksing
|
Drugs & Compounds
for PHF20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PHF20
|
Transcripts
for PHF20 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PHF20 gene: NM_016436.4 Additional cDNA sequence: AF220416.1 AF258787.1 AF348207.1 AK054597.1 AK090798.1 AK097498.1 AK314503.1 AL137330.1 AY027523.1 AY134747.1 BC006415.1 BC015538.2 BC016948.1 BC022933.1 BC048210.1 BC062681.1 BC080598.1 BC093405.1 BC150178.1 CR626103.1 CR626433.1 22 DOTS entries: DT.100044409 DT.305771 DT.95154061 DT.100780272 DT.92472013 DT.101985494 DT.443943 DT.443988 DT.92472026 DT.100042229 DT.100725372 DT.92472059 DT.100774767 DT.91796016 DT.92472043 DT.120825619 DT.75147899 DT.75148089 DT.95329770 DT.102831124 DT.120825578 DT.120825622 24/204 AceView cDNA sequences (see all 204): CR626103 BE220838 BC016948 AA304777 BQ056510 BQ436139 AA243681 AA737645 CA432348 C21160 BC080598 CB118505 BC006415 BQ028521 AW316526 Z43217 BM971287 AY134747 AI926894 BX100424 AK097498 AI992137 AU119982 AI377739
 highest scoring ESTs for PHF20:AL040923 AA112017 AA203667 AA307324 AA311702 AA608801 AA861739 AI377739 AI816058 AI873235 Unigene Cluster for PHF20: PHD finger protein 20 Hs.517044 [show with all ESTs]Unigene Representative Sequence: BC150178
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PHF20 (see all 12)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | - | | - | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PHF20
18 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373994 ENST00000481202 ENST00000473943 ENST00000461122 ENST00000461405
ENST00000485604 ENST00000449988 ENST00000374000(uc010gfo.1) ENST00000439301
ENST00000480940 ENST00000452270 ENST00000486408 ENST00000339089(uc002xei.1)
ENST00000495338 ENST00000413965 ENST00000374012(uc002xeh.2 uc002xel.1 uc002xem.1 uc002xej.1 uc002xek.1)
ENST00000420233 ENST00000496305
|
Expression
for PHF20 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PHF20 expression in normal and diseased human tissues
1 / 2 / 3 15 probe-sets matching PHF20 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 50384_s_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.50 |
0.90 |
T49488 |
0.80 |
0.80 |
0.80 |
1 |
| 59348_g_at2, 3
|
U95-C |
1 |
0.94 |
1.00 |
0.88 |
1.00 |
AA203667 |
0.80 |
1.00 |
0.91 |
1 |
| 59343_at2, 3
|
U95-C |
1 |
0.94 |
1.00 |
0.79 |
0.93 |
AL040923 |
1.00 |
1.00 |
1.00 |
1 |
| 51684_at2, 3
|
U95-C |
1 |
0.88 |
1.00 |
0.89 |
1.24 |
W76160 |
0.80 |
1.00 |
0.91 |
1 |
| 35050_at2, 3
|
U95-A |
2 |
0.81 |
0.93 |
0.94 |
0.65 |
X82068 |
0.20 |
0.25 |
0.23 |
2 |
| 77574_at2, 3
|
U95-E |
1 |
0.69 |
1.00 |
0.57 |
1.17 |
AI816058 |
0.80 |
1.00 |
0.91 |
1 |
| 32884_at2, 3
|
U95-A |
1 |
0.69 |
1.00 |
-0.12 |
0.29 |
L09749 |
0.20 |
0.50 |
0.38 |
1 |
| 59345_at2, 3
|
U95-C |
1 |
0.44 |
1.00 |
0.94 |
1.13 |
AA203667 |
0.80 |
1.00 |
0.91 |
1 |
| 209423_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AY027523 |
0.80 |
0.88 |
0.84 |
1 |
| 206567_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_016436 |
0.60 |
1.00 |
0.82 |
1 |
| 209422_at2
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1569906_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 209423_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206567_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 209422_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PHF20 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTGAGGGGCT
SOURCE GeneReport for Unigene cluster: Hs.517044
Expression variation in blood from EXPOLDB for PHF20 UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0Tissue specificity: Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed inbrain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer celllines while it is not expressed in the respective normal tissues
SABiosciences Custom PCR Arrays for PHF20
|
Orthologs
for PHF20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PHF20 gene from 5/8 species (see all 8)
About this table Species with no ortholog for PHF20
ENSEMBL Gene Tree for PHF20 (if available) |
Paralogs
for PHF20 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PHF20 gene
- PHF20L12
PHF20 for paralogs About GeneDecksing
|
Genomic Variants
for PHF20 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 20 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PHF20 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PHF20
1 CNV: 5135 | | QIAGEN SeqTarget long-range PCR primers for resequencing PHF20 |
|
Disorders & Mutations
for PHF20 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PHF20 for disorders About GeneDecksing
OMIM: 610335
Export disorders and mutations for PHF20 gene to outside databases
|
Medical News
for PHF20 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PHF20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for PHF20 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with PHF20)- Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls. (PubMed id 11703362)1, 2, 7 Fischer U....Meese E. (2001)
- Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)1, 2, 7 Behrends U.... Mautner J. (2003)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2 Wang Y....Chen W.-F. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Identification of genes associated with non-small-cel l lung cancer promotion and progression. (PubMed id 19473719)1 Bankovic J....Tanic N. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
|
External Searches for PHF20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PHF20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PHF20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PHF20 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PHF20 gene:
Search GeneIP for patents involving PHF20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PHF20 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for PHF20 |
| | | | Search Tocris compounds for PHF20 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for PHF20 |
| |
|
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