Aliases &
Descriptions
for PIK3CA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| phosphoinositide-3-kinase, catalytic, alpha polypeptide1 2 | | MGC1421612 | | PtdIns-3-kinase subunit p110-alpha2 3 | | phosphatidylinositol 3-kinase, catalytic, alpha polypeptide2 | | Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha2 3 | | PtdIns-3-kinase p1102 | | PtdIns-3-kinase subunit alpha2 3 | | p110-alpha2 | | PI3K-alpha2 3 | | phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha2 | | PI3-kinase subunit alpha2 3 | | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform2 | | MGC1421632 | | PI3-kinase p110 subunit alpha2 | | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform2 | | EC 2.7.1.1533 | | PI3K2 | | |
Export aliases for PIK3CA gene to outside databasesPrevious GC identifers: GC03P175570 GC03P179758 GC03P180318 GC03P180237 GC03P180399 GC03P180349 GC03P178865 |
Summaries
for PIK3CA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PIK3CA:
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The proteinencoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P andPtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. (provided byRefSeq)
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336Function: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2
 summary
for PIK3CA: PI 3-Kinases (phosphoinositide 3-kinases, PI3Ks) are family of lipid kinases capable of phosphorylating the
3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of
cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell
migration. The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric
consisting of a regulatory subunit and a 110 kDA catalytic subunits (3 forms in class 1A : alpha-, beta- and
delta- and one in class 1B : gamma-). PI 3-kinases p110 alpha- and beta- are ubiquitously expressed whilst
p110 delta- expression is associated with leukocytes. Activating mutations in the p110alpha- subunit have
recently been discovered in certain types of cancer cell. Class II PI 3-kinases are large homomeric enzymes
(C2alpha-, beta- and gamma-) that are sensitive to wortmannin (although less sensitive than Class 1 PI
3-kinases) but are resistant to LY 292002. Class III contains just one member, hVps34p, which is thought to
play an important role in both protein sorting and nutrient sensing in concert with the mTOR pathway.
|
Genomic Views
for PIK3CA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIK3CA gene promoter:
CUTL1 FOXO4 FOXO1a p300 PPAR-gamma2 Egr-1 PPAR-gamma1 p53 FOXC1 IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIK3CA
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PIK3CA  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.3 Ensembl cytogenetic band: 3q26.32 HGNC cytogenetic band: 3q26.3PIK3CA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P176269: view genomic region
(about GC identifiers)
Start:
|
176,269,843 bp from pter |
End:
|
176,355,772 bp from pter |
Size:
|
85,930 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr3+ 178,865,902-178,957,881 |
RefSeq DNA sequence:- NC_000003.11 NT_005612.16
|
Proteins
for PIK3CA gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336 (See
protein sequence)Recommended Name: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Size: 1068 amino acids; 124284 Da
Subunit: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interactswith RUFY3 (By similarity). Interacts with RASD2 (By similarity)
PDB structures from  and Proteopedia  :2ENQ (3D)
2RD0 (3D)
3HHM (3D)
3HIZ (3D)
Secondary accessions: Q14CW1 Q99762Explore the universe of human proteins at neXtProt for PIK3CA: NX_P42336
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006209.2
ENSEMBL proteins: ENSP00000418145 ENSP00000263967 ENSP00000417479
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PIK3CA for ontologies About GeneDecksing
Antibodies for PIK3CA:
Assays for PIK3CA: |
Protein
Domains/
Families
for PIK3CA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIK3CA for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry P42336ProtoNet protein and cluster: P42336 4 Blocks protein families: IPB000008 C2 domain IPB000341 Phosphoinositide 3-kinase IPB000403 Phosphatidylinositol 3- and 4-kinase IPB003113 Phosphatidylinositol 3-kinase
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336Similarity: Belongs to the PI3/PI4-kinase familySimilarity: Contains 1 C2 domainSimilarity: Contains 1 PI3K/PI4K domain |
Gene Function
for PIK3CA gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336Function: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol3,4,5-trisphosphateEnzyme Number (IUBMB): EC 2.7.1.153
Genatlas biochemistry entry for PIK3CA:phosphatidylinositol-3-kinase,catalytic,class 1,alpha subunit,widely expressed, activated by growth factors,throughbinding p785 adaptor proteins (PIK3R1,PIK3R2,PIK3R3),activating Akts in the antiapoptotic PIK3 pathway,antagonized byPTEN,mediating angiogenes is and expression of VEGF in endothelial cells,involved in the regulation of cellularprocesses,potentially oncogenic in ovarian cancer5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9): About this table
PIK3CA for ontologies About GeneDecksing
Animal Models: 15/16 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Pik3ca) (see all 16):
PIK3CA for phenotypes About GeneDecksing
|
Pathways & Interactions
for PIK3CA gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PIK3CA for pathways About GeneDecksing
5/68  Millipore Pathways for PIK3CA (see all 68)
5/130  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PIK3CA (see all 130)
2 
Cell Signaling Technology (CST) Pathways for PIK3CA
5/40  Kegg Pathways (Kegg details for PIK3CA) (see all 40):
SABiosciences Pathway-Focused PCR Arrays including PIK3CA (see all 8): PAHS-030A PAHS-040A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PIK3CA
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIK3CA
5/280 Interacting proteins for PIK3CA (P423361, 2 ENSP000002639673) via UniProtKB, MINT, and/or STRING (see all 280)About this table
5/19 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 19): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006006 | glucose metabolic process |
IEA | -- | | GO:0006468 | protein phosphorylation |
IEA | -- | | GO:0006916 | anti-apoptosis |
IEA | -- | | GO:0007165 | signal transduction |
IEA | -- | | GO:0007173 | epidermal growth factor receptor signaling pathway |
TAS | -- |
About this table
PIK3CA for ontologies About GeneDecksing
|
Drugs & Compounds
for PIK3CA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PIK3CA for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for PIK3CA |
Compounds for PIK3CA available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| LY 294002 hydrochloride | Selective PI 3-kinase inhibitor | [154447-36-6] | | Quercetin | Non-selective PI 3-kinase inhibitor | [117-39-5] | | PI 103 hydrochloride | Inhibitor of PI 3-kinase, mTOR and DNA-PK | [371935-74-9] | | BAG 956 | Dual PI 3-kinase and PDK1 inhibitor | [853910-02-8] | | PI 828 | PI 3-kinase inhibitor, more potent than LY 294002 (Cat.No. 1130) | [942289-87-4] |
About this table
10/86  Novoseek chemical compound relationships for PIK3CA gene (see all 86)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphatidylinositol |
93.1 |
425 |
8663584 (4), 12897244 (3), 7713498 (2), 17377809 (2) (see all 99) |
| phosphoinositide |
89 |
184 |
11882383 (2), 10926936 (2), 19679877 (2), 12545728 (2) (see all 99) |
| wortmannin |
87.1 |
162 |
10794659 (3), 11559593 (3), 8657148 (2), 10671571 (2) (see all 99) |
| rapamycin |
81.3 |
71 |
20115955 (2), 18676851 (2), 12433206 (1), 19061482 (1) (see all 55) |
| phosphatidylinositol-3,4,5-trisphosphate |
74.2 |
14 |
12897244 (2), 20054340 (1), 9593670 (1), 19509113 (1) (see all 10) |
| naphtho(1,2-b)furan-4,5-dione |
71.6 |
1 |
20371243 (1), 20036260 (1) |
| ly294002 |
70.2 |
50 |
19383818 (3), 18262558 (2), 15277479 (2), 12621049 (2) (see all 28) |
| ctmp |
64.1 |
1 |
16150119 (1) |
| tyrosine |
60.1 |
62 |
10763917 (2), 16311104 (2), 18449193 (2), 10963852 (1) (see all 47) |
| glycogen |
60.1 |
22 |
17055733 (1), 18782353 (1), 20471052 (1), 16170333 (1) (see all 22) |
About this table
|
Transcripts
for PIK3CA gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PIK3CA gene: NM_006218.2 Additional cDNA sequence: AK021510.1 CR601404.1 DQ787424.1 DQ910907.1 5 DOTS entries: DT.313816 DT.99950166 DT.100741537 DT.99939096 DT.100737416 24/74 AceView cDNA sequences (see all 74): AL706270 AI679006 BG497751 N33289 BP337031 AA331546 BX108528 AA905413 BX437220 AA732379 BM470620 AI245465 BQ228953 AI632172 BU167122 BX473473 BE246374 AA298585 BX482711 AU280420 CA310666 BX503208 AA661803 BP336348
 highest scoring ESTs for PIK3CA:AA190799 AA298585 AA661803 AA837525 AA847833 AI632172 AI679006 AU151957 AV651586 AW068262 Unigene Clusters for PIK3CA: Phosphoinositide-3-kinase, catalytic, alpha polypeptide Hs.85701 [show with all ESTs], Hs.553498 [show with all ESTs]Unigene Representative Sequences: NM_006218, AK021510
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000477735 ENST00000263967(uc003fjk.2) ENST00000468036 ENST00000462255
|
Expression
for PIK3CA gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PIK3CA expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching PIK3CA gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 83177_at2
|
U95-E |
1 |
0.44 |
1.00 |
0.88 |
1.37 |
-- |
-- |
-- |
-- |
-- |
| 81516_at2, 3
|
U95-E |
2 |
0.44 |
0.58 |
0.87 |
1.23 |
R22204 |
0.20 |
1.00 |
0.72 |
1 |
| 41969_at2, 3
|
U95-B |
1 |
0.38 |
1.00 |
0.90 |
0.73 |
AA088326 |
0.20 |
1.00 |
0.72 |
1 |
| 40704_at2, 3
|
U95-A |
1 |
0.31 |
1.00 |
0.28 |
0.70 |
Z29090 |
0.80 |
1.00 |
0.91 |
1 |
| 204369_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_006218 |
0.60 |
1.00 |
0.82 |
1 |
| 235980_at2, 3
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
AA767763 |
0.20 |
1.00 |
0.72 |
1 |
| 231854_at2
|
U133-B |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 204369_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 235980_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 231854_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PIK3CA for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCCGATTTCA TTATGCCTTA
SOURCE GeneReport for Unigene clusters: Hs.85701 Hs.553498
Expression variation in blood from EXPOLDB for PIK3CA SABiosciences Expression via Pathway-Focused PCR Arrays including PIK3CA (see all 8): PAHS-030A PAHS-040A
|
Orthologs
for PIK3CA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PIK3CA gene from 5/9 species (see all 9)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
PIK3CA1 |
-- |
phosphoinositide-3-kinase, catalytic, alpha polypeptide |
96.13(n)
99.81(a) |
488084 XM_545208.2 XP_545208.2 |
chimpanzee
(Pan troglodytes) |
PIK3CA1 |
-- |
phosphoinositide-3-kinase, catalytic, alpha polypeptide |
99.94(n)
100(a) |
460858 XM_001167506.1 XP_001167506.1 |
cow
(Bos taurus) |
PIK3CA1 |
-- |
phosphoinositide-3-kinase, catalytic, alpha polypeptide |
96.35(n)
99.81(a) |
282306 NM_174574.1 NP_776999.1 |
mouse
(Mus musculus) |
Pik3ca1 , 5 |
3 (15.70 cM)5
|
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide1, 5 |
89.54(n)1
98.6(a)1 |
187061 NM_008839.11 NP_032865.11
AI4631075 AI5285675 (see all 22) |
chicken
(Gallus gallus) |
PIK3CA1 |
-- |
phosphoinositide-3-kinase, catalytic, alpha polypeptide |
85.3(n)
96.25(a) |
424971 NM_001004410.1 NP_001004410.1 |
About this table Species with no ortholog for PIK3CA
ENSEMBL Gene Tree for PIK3CA (if available) |
Paralogs
for PIK3CA gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PIK3CA gene
- PIK3C2B2 PIK3CD2 PIK3C2G2 PIK3C32 PIK3CB2 PIK3CG2 PIK3C2A2
PIK3CA for paralogs About GeneDecksing
|
Genomic Variants
for PIK3CA gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PIK3CA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PIK3CA
1 CNV: 91720
1 Indel: 59111 | | QIAGEN SeqTarget long-range PCR primers for resequencing PIK3CA |
|
Disorders & Mutations
for PIK3CA gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIK3CA for disorders About GeneDecksing
OMIM: 171834 disorders: 604370 114480 114500 137215 114550 211980 182000 162900 UniProtKB/Swiss-Prot: PK3CA_HUMAN, P42336
Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500] Defects in PIK3CA are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancyoriginating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasiveductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous.Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more thanone locus can be involved in different families or even in the same case Defects in PIK3CA are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer commonmalignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described,epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signsand symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550] Defects in PIK3CA are a cause of keratosis seborrheic (KERSEB) [MIM:182000]. A common benign skin tumor.Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. Thelesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface,followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance
10/80 Novoseek disease relationships for PIK3CA gene (see all 80)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
68.6 |
291 |
19573809 (6), 19384426 (5), 18059185 (4), 17575152 (4) (see all 99) |
| somatic mutations |
68.1 |
59 |
16168105 (4), 17052259 (3), 16533766 (2), 18951408 (2) (see all 33) |
| tumors |
65.5 |
343 |
17714348 (7), 15928251 (6), 19237633 (5), 16322209 (4) (see all 99) |
| glioblastoma |
65.2 |
58 |
17235514 (5), 18676851 (5), 17050665 (4), 12782577 (4) (see all 22) |
| follicular thyroid cancer |
61.6 |
4 |
15928251 (2), 17426084 (1) |
| thyroid carcinoma anaplastic |
60.9 |
5 |
16288007 (2), 15928251 (1), 18000091 (1), 18502332 (1) |
| breast cancer |
56.5 |
135 |
16168105 (7), 19685490 (5), 17202311 (5), 18676830 (4) (see all 57) |
| cowden disease |
55.9 |
1 |
19897009 (1) |
| glioblastoma multiforme |
51.8 |
4 |
17050665 (1), 15924253 (1), 15143086 (1) |
| ovarian cancer |
51.7 |
46 |
12874030 (4), 16839745 (3), 15028555 (3), 18270270 (3) (see all 23) |
About this table
Genetic Association Database (GAD): PIK3CA
Human Genome Epidemiology (HuGE) Navigator: PIK3CA (106 documents)
Export disorders and mutations for PIK3CA gene to outside databases
|
Medical News
for PIK3CA gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for PIK3CA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
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10/1165 PubMed articles for PIK3CA gene, integrated from 7 sources (see all 1165):
(articles sorted by number of sources associating them with PIK3CA)- PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. (PubMed id 16353168)1, 2, 4 Buttitta F....Marchetti A. (2006)
- The prevalence of PIK3CA mutations in gastric and colon cancer. (PubMed id 15994075)1, 2, 4 Velho S....Seruca R. (2005)
- Mutations of PIK3CA in gastric adenocarcinoma. (PubMed id 15784156)1, 2, 7 Li V.S.W.... Leung S.Y. (2005)
- Somatic mutation and gain of copy number of PIK3CA in human breast cancer. (PubMed id 16168105)1, 4, 7 Wu G....Sidransky D. (2005)
- High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. (PubMed id 16322209)1, 2, 7 Oda K.... McCormick F. (2005)
- PIK3CA mutations in head and neck squamous cell carcinoma. (PubMed id 16533766)1, 2, 7 Qiu W.... Su G.H. (2006)
- Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors. (PubMed id 15928251)1, 4, 7 Wu G....Xing M. (2005)
- Mutation of the PIK3CA gene in ovarian and breast cancer. (PubMed id 15520168)1, 2, 7 Campbell I.G....Phillips W.A. (2004)
- Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. (PubMed id 17673550)1, 2, 7 Hafner C....Real F.X. (2007)
- PIK3CA mutations in breast cancer are associated with poor outcome. (PubMed id 16317585)1, 4, 7 Li S.Y....Iacopetta B. (2006)
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External Searches for PIK3CA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PIK3CA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PIK3CA gene
(According to HUGE)
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Specialized Databases showing PIK3CA gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for PIK3CA gene:
Search GeneIP for patents involving PIK3CA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PIK3CA gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
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 | Antibodies & Assays for PIK3CA
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