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PIN4 Gene

protein-coding GIFtS: 56

GC0XP065157

protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
(Previous names: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)¹ ²		OTTHUMP00000217485²
EPVH¹ ² ⁵		OTTHUMP00000023527²
PAR14¹ ² ⁵		peptidyl-prolyl cis-trans isomerase NIMA-interacting 4²
PAR17¹ ²		OTTHUMP00000217483²
Peptidyl-prolyl cis/trans isomerase EPVH² ³		parvulin-14²
Peptidyl-prolyl cis-trans isomerase Pin4² ³		parvulin-17²
Rotamase Pin4² ³		MGC138486²
PPIase Pin4² ³		Parvulin-14³
hPar14² ³		Par17³
hEPVH² ³		Par14³
hPar17² ³		EC 5.2.1.8³
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)¹		Parvulin-17³
eukaryotic parvulin homolog²

External Ids:	HGNC: 8992¹	Entrez Gene: 5303²	Ensembl: ENSG00000102309⁷	UniProtKB: Q9Y237³

Export aliases for PIN4 gene to outside databases

Previous GC identifers: GC0XP067133 GC0XP068641 GC0XP069634 GC0XP070268 GC0XP071184 GC0XP071318 GC0XP071401

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIN4:

This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The

encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin

remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. (provided

by RefSeq)

UniProtKB/Swiss-Prot: PIN4_HUMAN, Q9Y237

Function: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent

AT-rich stretches of double-stranded DNA

Function: Isoform 2 binds to double-stranded DNA

Gene Wiki entry for PIN4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIN4 gene promoter:
         LUN-1   RFX1   C/EBPalpha   Meis-1   ISGF-3   p300   E4BP4   YY1   Chx10   CUTL1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PIN4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1

PIN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIN4 gene location

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP065157: view genomic region (about GC identifiers)

Start:	65,156,426 bp from pter
End:	65,238,895 bp from pter
Size:	82,470 bases
Orientation:	plus strand

1 alternative location:

ChrX+ 71,401,203-71,522,776

RefSeq DNA sequence:

NC_000023.10 NT_011669.17

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PIN4_HUMAN, Q9Y237 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Size: 131 amino acids; 13810 Da

Subunit: Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes (By similarity)

Subcellular location: Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in

the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1

Subcellular location: Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane

potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to

mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide

Sequence caution: Sequence=AAH05234.2; Type=Erroneous initiation; Sequence=AAH70288.1; Type=Erroneous initiation;

Sequence=AAI04654.1; Type=Erroneous initiation; Sequence=AAI11395.1; Type=Erroneous initiation;

PDB structure from and Proteopedia :

1EQ3 (3D)

1FJD (3D)

Secondary accessions: A8E0G6 Q0D2H3 Q3MHV0 Q52M21 Q5HYW6 Q6IRW4

Alternative promoter usage: 2 isoforms: Q9Y237-1 Q9Y237-2

Explore the universe of human proteins at neXtProt for PIN4: NX_Q9Y237

Post-translational modifications:

Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at

Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a

prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the

nucleus¹

Isoform 2 is sumoylated by SUMO2 and SUMO3¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001164218.1 NP_006214.2

ENSEMBL proteins:

ENSP00000421392 ENSP00000402330 ENSP00000418519 ENSP00000362773 ENSP00000218432 ENSP00000421676

ENSP00000394066 ENSP00000409154

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PIN4
	GenScript Custom Purified and Recombinant Proteins Services for PIN4
	Novus Biologicals Proteins for PIN4
	Novus Biologicals Lysate for PIN4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005759	mitochondrial matrix	IEA	--

About this table

PIN4 for ontologies About GeneDecksing

Antibodies for PIN4:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PIN4
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for PIN4
	Novus Biologicals Antibodies for PIN4
	Browse antibodies at Epitomics

Assays for PIN4:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PIN4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PIN4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIN4 for domains About GeneDecksing

1 InterPro domain/family:

IPR000297 PPIase_PpiC

Graphical View of Domain Structure for InterPro Entry Q9Y237

ProtoNet protein and cluster: Q9Y237

1 Blocks protein family: IPB000297 PpiC-type peptidyl-prolyl cis-trans isomerase

UniProtKB/Swiss-Prot: PIN4_HUMAN, Q9Y237

Domain: The PPIase domain enhances mitochondrial targeting

Similarity: Belongs to the ppiC/parvulin rotamase family. PIN4 subfamily

Similarity: Contains 1 PpiC domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PIN4_HUMAN, Q9Y237

Function: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent

AT-rich stretches of double-stranded DNA

Function: Isoform 2 binds to double-stranded DNA

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme Number (IUBMB): EC 5.2.1.8

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PIN4 Sigma-Aldrich shRNA for PIN4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PIN4 OriGene shRNA RFP (see all 3): PIN4 OriGene basic RS shRNA (see all 3): PIN4 OriGene siRNA (see all 3): PIN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIN4

miRNA:		Sigma-Aldrich microRNA Mimics for PIN4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIN4
		Search SABiosciences for Assays for microRNAs that regulate PIN4

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PIN4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PIN4 OriGene untagged cDNA clones in CMV expression vector (see all 2): PIN4 OriGene 3'-UTR clone: PIN4 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PIN4
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PIN4

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003681	bent DNA binding	IDA	12144781
GO:0003690	double-stranded DNA binding	IDA	17875217
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA	--
GO:0016853	isomerase activity	IEA	--

About this table

PIN4 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for PIN4

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PIN4

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006364	rRNA processing	IMP	19369196
GO:0006457	protein folding	IEA	--

About this table

PIN4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PIN4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PIN4 Sigma-Aldrich shRNA for PIN4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PIN4 OriGene shRNA RFP (see all 3): PIN4 OriGene basic RS shRNA (see all 3): PIN4 OriGene siRNA (see all 3): PIN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PIN4

miRNA:		Sigma-Aldrich microRNA Mimics for PIN4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PIN4
		Search SABiosciences for Assays for microRNAs that regulate PIN4

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): PIN4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): PIN4 OriGene untagged cDNA clones in CMV expression vector (see all 2): PIN4 OriGene 3'-UTR Clone: PIN4 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PIN4

Primers:		OriGene genome-wide validated SYBR primer pairs: PIN4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PIN4: PPH07806A

REFSEQ mRNAs for PIN4 gene (2 alternative transcripts):

NM_001170747.1 NM_006223.3

Additional cDNA sequence:

AB009690.1 AF143096.1 AK127605.1 BC005234.1 BC070288.1 BC093700.1 BC104653.1 BC111394.1

BC112281.1

11 DOTS entries:

DT.212927 DT.99944350 DT.92430198 DT.121296600 DT.97858408 DT.86854415 DT.95267739 DT.95079625

DT.92430199 DT.121296565 DT.95170092

24/147 AceView cDNA sequences (see all 147):

BF434549 AI692216 AA318025 AI929422 AW272353 NM_006223 AI632725 CK725069

BM969549 AI879437 AI695335 AI308064 BE552230 BF476049 AI692743 AI878885

CD364808 AI348662 AW589840 BG575501 BF196032 AA471033 AI929465 AW162154

highest scoring ESTs for PIN4:

AB009690 AA095141 AA318025 AA418383 AA418536 AA452313 AA471033 AA507634 AA527909 AA628534

Unigene Cluster for PIN4:

Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)

Hs.655623 [show with all ESTs]

Unigene Representative Sequence: AK127605

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PIN4

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b
SP1:											-		-						-
SP2:											-		-
SP3:											-		-		-				-
SP4:													-
SP5:											-

About this scheme

ECgene alternative splicing isoforms for PIN4
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373662 ENST00000446576 ENST00000475071 ENST00000373669 ENST00000218432(uc004eam.2)

ENST00000496835(uc004eao.1) ENST00000439980 ENST00000423432

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PIN4 expression in normal and diseased human tissues

¹ / ² / ³

9 probe-sets matching PIN4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41616_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB009690	1.00	0.90	0.95	1
204572_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006223	0.60	1.00	0.82	1
204571_x_at²^{, 3}	U133-A	3	1.00	0.85	--	--	BE797213	0.80	1.00	0.91	1
214224_s_at²^{, 3}	U133-A	3	1.00	0.80	--	--	BE674061	0.60	1.00	0.82	1
214225_at²^{, 3}	U133-A	1	0.73	1.00	--	--	BE674061	0.60	1.00	0.82	1
204572_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204571_x_at²	U133Plus2	3	1.00	0.85	--	--	--	--	--	--	--
214224_s_at²	U133Plus2	3	1.00	0.80	--	--	--	--	--	--	--
214225_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

PIN4 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PIN4 gene electronic northern expression

About these images

CGAP SAGE TAG: GTGGGACCAT

SOURCE GeneReport for Unigene cluster: Hs.655623

Expression variation in blood from EXPOLDB for PIN4

UniProtKB/Swiss-Prot: PIN4_HUMAN, Q9Y237

Tissue specificity: Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform

2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and

submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed

Primers:		OriGene genome-wide validated SYBR primer pairs: PIN4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PIN4: PPH07806A

SABiosciences Custom PCR Arrays for PIN4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PIN4 gene from 5/16 species (see all 16)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PIN4¹	--	protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, more	90.08(n) 90.08(a)	607090 XM_843912.1 XP_849005.1
chimpanzee (Pan troglodytes)	PIN4¹	--	protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, more	96.92(n) 95.38(a)	743052 XM_001161176.1 XP_001161176.1
mouse (Mus musculus)	Pin4^{1 , 5}	X (45.14 cM)⁵	protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, more^{1, 5}	94.4(n)¹ 96.95(a)¹	69713¹ NM_027181.1¹ NP_081457.1¹ AK010338⁵ AW012413⁵ (see all 7)
chicken (Gallus gallus)	PIN4¹	--	protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, more	76.53(n) 88(a)	422134 XM_420136.2 XP_420136.2
zebrafish (Danio rerio)	zgc:110008¹	--	zgc:110008	72.4(n) 84.37(a)	553574 NM_001020553.1 NP_001018389.1

About this table Species with no ortholog for PIN4

ENSEMBL Gene Tree for PIN4 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

4 related pseudogenes

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs11415^1,2	C,F,	71416721(+)	`GTGGCC/TGCACA`	6	A	ref¹ syn¹		7		NA NS EA	497
rs878929^1,2	C,F,A,H,	71474318(-)	`tctacA/Tggaga`	1	--	int¹		11		MN NS EA NA WA	712
rs1885483^1,2	C	71471283(+)	`AAAGTG/ATATAT`	1	--	int¹		7		NA NS EA	531
rs1885484^1,2	C	71482917(+)	`GTGAAC/TGGGCT`	1	--	ut3¹		7		NA EA NS	668
rs1985287^1,2	C,F,A	71461523(+)	`tagccG/Aggcat`	1	--	int¹		3		NA WA	9
rs2368669^1,2	C,A,H	71461511(+)	`aaaatA/Gcaaaa`	1	--	int¹		5		NA WA	12
rs2887310^1,2	--	71473402(+)	`cccggA/Gaggcg`	1	--	int¹		0	--	--	--	--
rs2984354^1,2	--	71460862(+)	`AGGTCA/CATATG`	1	--	int¹		0	--	--	--	--
rs2984355^1,2	C,F,A,H,	71461061(+)	`aattcA/Ttgtgt`	1	--	int¹		7		NS EA NA WA	425
rs2984356^1,2	C,F,A,H,	71478498(+)	`tcagaA/Ctgcct`	1	--	int¹		10		NS EA NA WA	521

About this table

HapMap Linkage Disequilibrium images for PIN4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PIN4
3 CNVs: 96754 96753 74005

QIAGEN SeqTarget long-range PCR primers for resequencing PIN4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PIN4 for disorders About GeneDecksing

OMIM: 300252

1 PharmGKB disease relationship for PIN4 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

About this table

Locus Specific Mutation Databases (LSDB): PIN4

Export disorders and mutations for PIN4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/21 PubMed articles for PIN4 gene, integrated from 7 sources (see all 21):
(articles sorted by number of sources associating them with PIN4)

The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. (PubMed id 17875217)^{1, 2, 3} Kessler D.... Mueller J.W. (2007)
Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation. (PubMed id 16522211)^{1, 2, 3} Mueller J.W.... Bayer P. (2006)
Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14. (PubMed id 11162102)^{1, 2, 7} Terada T.... Uchida T. (2001)
Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14. (PubMed id 12860119)^{1, 2, 7} Reimer T.... Fischer G. (2003)
Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage. (PubMed id 19369196)^{1, 2} Fujiyama-Nakamura S....Takahashi N. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding. (PubMed id 12144781)^{1, 2} Surmacz T.A....Bayer P. (2002)
NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein. (PubMed id 10966801)^{1, 2} Sekerina E.... Bayer P. (2000)
Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase. (PubMed id 10100858)^{1, 2} Uchida T.... Rahfeld J.-U. (1999)
Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases. (PubMed id 10364457)^{1, 2} Rulten S.L.... Kay J.E. (1999)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5303	HGNC: 8992	AceView: PIN4	Ensembl:ENSG00000102309	euGenes: HUgn5303
ECgene: PIN4	H-InvDB: PIN4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Intellectual Property for PIN4 gene
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GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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PIN4 (Gene Symbol)
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
EPVH
PAR14
PAR17
Peptidyl-prolyl cis/trans isomerase EPVH
Peptidyl-prolyl cis-trans isomerase Pin4
Rotamase Pin4
PPIase Pin4
hPar14
hEPVH
hPar17
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
eukaryotic parvulin homolog
OTTHUMP00000217485
OTTHUMP00000023527
peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
OTTHUMP00000217483
parvulin-14
parvulin-17
MGC138486
Parvulin-14
Par17
Par14
EC 5.2.1.8
Parvulin-17

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PIN4 Gene

protein-coding GIFtS: 56

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