Aliases &
Descriptions
for PLA2G5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| phospholipase A2, group V1 2 | | hVPLA(2)2 | | Group V phospholipase A22 3 | | DKFZp686C22942 | | Phosphatidylcholine 2-acylhydrolase 52 3 | | calcium-dependent phospholipase A22 | | PLA2-102 3 | | MGC462052 | | GV-PLA22 | | EC 3.1.1.43 | | Ca2+-dependent phospholipase A22 | | |
Export aliases for PLA2G5 gene to outside databasesPrevious GC identifers: GC01P019967 GC01P019431 GC01P019866 GC01P020142 GC01P020269 GC01P020354 |
Summaries
for PLA2G5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PLA2G5:
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretoryphospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids togenerate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzeslinoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatoryresponses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-lengthnature has not been determined. (provided by RefSeq)
UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozymehydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonylphosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonylphosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiacmuscle
 summary
for PLA2G5: Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.
Gene Wiki entry for PLA2G5 |
Genomic Views
for PLA2G5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLA2G5 gene promoter:
SRF POU2F1 RORalpha1 HSF1 (long) c-Myb HSF2 AhR RORalpha2 C/EBPalpha CHOP-10
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLA2G5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36-p34 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36-p34PLA2G5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P018642: view genomic region
(about GC identifiers)
Start:
|
18,642,531 bp from pter |
End:
|
18,664,224 bp from pter |
Size:
|
21,694 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 20,354,672-20,417,683 |
RefSeq DNA sequence:- NC_000001.10 NT_004610.19
|
Proteins
for PLA2G5 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877 (See
protein sequence)Recommended Name: Calcium-dependent phospholipase A2 precursor Size: 138 amino acids; 15674 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Secreted
PDB structures from  and Proteopedia  :2GHN (3D)
Secondary accessions: Q8N435Explore the universe of human proteins at neXtProt for PLA2G5: NX_P39877
Post-translational modifications:
This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins1
REFSEQ proteins: NP_000920.1
ENSEMBL proteins: ENSP00000364249
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PLA2G5 for ontologies About GeneDecksing
Antibodies for PLA2G5:
Assays for PLA2G5: |
Protein
Domains/
Families
for PLA2G5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLA2G5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P39877ProtoNet protein and cluster: P39877 1 Blocks protein family: IPB001211 Phospholipase A2
UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877Similarity: Belongs to the phospholipase A2 family |
Gene Function
for PLA2G5 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozymehydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonylphosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonylphosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiacmuscleCatalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylateBiophysicochemical properties: pH dependence: Optimum pH is 6.5. Activity remains high up to pH 9.0;Enzyme Number (IUBMB): EC 3.1.1.4
Genatlas biochemistry entry for PLA2G5:phospholipase A2,group V,Ca2+ dependent,cytosolic,strongly expressed in heart5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PLA2G5 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Pla2g5):
PLA2G5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PLA2G5 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PLA2G5 for pathways About GeneDecksing
2  Millipore Pathways for PLA2G5
5/16  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for PLA2G5 (see all 16)
5/14  Kegg Pathways (Kegg details for PLA2G5) (see all 14):
SABiosciences Pathway-Focused PCR Array including PLA2G5: PAHS-091A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PLA2G5
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PLA2G5
5/65 Interacting proteins for PLA2G5 (ENSP000003642493) via UniProtKB, MINT, and/or STRING (see all 65)About this table
5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
IEA | -- | | GO:0006663 | platelet activating factor biosynthetic process |
IEA | -- | | GO:0016042 | lipid catabolic process |
IEA | -- | | GO:0019370 | leukotriene biosynthetic process |
IEA | -- | | GO:0034097 | response to cytokine stimulus |
IEA | -- |
About this table
PLA2G5 for ontologies About GeneDecksing
|
Drugs & Compounds
for PLA2G5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
PLA2G5 for compounds About GeneDecksing
Compounds for PLA2G5 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| RHC 80267 | Diacylglycerol lipase inhibitor | [83654-05-1] | | AACOCF3 | Phospholipase A2 inhibitor | [149301-79-1] | | OBAA | Phospholipase A2 inhibitor | -- | | PACOCF3 | Phospholipase A2 inhibitor | [141022-99-3] |
About this table
2  Novoseek chemical compound relationships for PLA2G5 gene
About this table
|
Transcripts
for PLA2G5 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PLA2G5 gene: NM_000929.2 Additional cDNA sequence: AK097693.1 BC036792.1 CR607562.1 U03090.1 9 DOTS entries: DT.210917 DT.91670033 DT.100019470 DT.97838206 DT.100708852 DT.101981572 DT.101981573 DT.100813257 DT.121375427 24/53 AceView cDNA sequences (see all 53): AI051138 AA526578 BU730619 AW132005 BM710485 BU727090 BM663112 AA293827 CR607562 BX398027 AI420062 AI418243 BC036792 CD013950 AV709457 BX335144 CD013948 BX389673 AI583184 BM716326 AA402475 CD013951 U03090 CK003597
 highest scoring ESTs for PLA2G5:U03090 AA526578 AA973633 AI051138 AI418243 AI420062 AI468128 AI583184 AI701153 AI768971 Unigene Cluster for PLA2G5: Phospholipase A2, group V Hs.319438 [show with all ESTs]Unigene Representative Sequence: NM_000929
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G5 (see all 10)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PLA2G5
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486277(uc001bcw.2 uc001bcx.2) ENST00000465698 ENST00000460175
ENST00000469069 ENST00000489871 ENST00000498348 ENST00000375108(uc001bcy.2)
ENST00000478803
|
Expression
for PLA2G5 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PLA2G5 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching PLA2G5 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39629_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
1.00 |
1.00 |
U03090 |
1.00 |
1.00 |
1.00 |
1 |
| 206178_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_000929 |
0.60 |
1.00 |
0.82 |
1 |
| 215870_s_at2
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215871_at2
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206178_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215870_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215871_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PLA2G5 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGAACCTCTG
SOURCE GeneReport for Unigene cluster: Hs.319438
Expression variation in blood from EXPOLDB for PLA2G5 UniProtKB/Swiss-Prot: PA2G5_HUMAN, P39877Tissue specificity: Heart, placenta and less abundantly, in lung
SABiosciences Expression via Pathway-Focused PCR Array including PLA2G5: PAHS-091A
|
Orthologs
for PLA2G5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PLA2G5 gene from 5/6 species (see all 6)
About this table Species with no ortholog for PLA2G5
ENSEMBL Gene Tree for PLA2G5 (if available) |
Paralogs
for PLA2G5 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PLA2G5 gene
- ENSG000002321712 PLA2G2F2 PLA2G2E2 PLA2G2D2 PLA2G2A2 PLA2G1B2 OC902 PLA2G102
- ENSG000002361862 PLA2G2C2
PLA2G5 for paralogs About GeneDecksing
|
Genomic Variants
for PLA2G5 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for PLA2G5
9 CNVs: 48235 84111 63202 34760 74398 74396 97309 43756 84109
3 Indels: 84112 84110 74397 | | QIAGEN SeqTarget long-range PCR primers for resequencing PLA2G5 |
|
Disorders & Mutations
for PLA2G5 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLA2G5 for disorders About GeneDecksing
OMIM: 601192
Human Genome Epidemiology (HuGE) Navigator: PLA2G5 (4 documents)
Export disorders and mutations for PLA2G5 gene to outside databases
|
Medical News
for PLA2G5 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PLA2G5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/39 PubMed articles for PLA2G5 gene, integrated from 7 sources (see all 39):
(articles sorted by number of sources associating them with PLA2G5)- Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. (PubMed id 8300559)1, 2, 3 Chen J.... Tischfield J.A. (1994)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human. (PubMed id 8838795)1, 3 Tischfield J.A....Lusis A.J. (1996)
- Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. (PubMed id 17545304)1, 7 Wootton P.T....Talmud P.J. (2007)
- Presence of secretory group IIa and V phospholipase A2 and cytosolic group IValpha phospholipase A2 in chondrocytes from patients with rheumatoid arthritis. (PubMed id 15259375)1, 7 Leistad L....Johansen B. (2004)
- Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. (PubMed id 12796497)1, 7 Munoz N.M....Cho W. (2003)
- Expression and characterization of human group V phospholipase A2. (PubMed id 9767110)1, 7 Chen Y. and Dennis E.A. (1998)
- Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. (PubMed id 16785555)1, 7 Munoz N.M....Leff A.R. (2006)
- Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells. (PubMed id 16476735)1, 7 Wijewickrama G.T....Cho W. (2006)
|
External Searches for PLA2G5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLA2G5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLA2G5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLA2G5 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PLA2G5 gene:
Search GeneIP for patents involving PLA2G5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLA2G5 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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