Aliases &
Descriptions
for PLGLB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| plasminogen-like B21 2 | | plasminogen-related protein B2 | | plasminogen pseudogene 11 2 | | type B plasminogen related2 | | PLGP12 3 | | PLGL3 | | PLGLB12 | | PRGB3 | | OTTHUMP000002035942 | | |
Export aliases for PLGLB2 gene to outside databasesPrevious GC identifers: GC00U921622 GC02P087887 |
Summaries
for PLGLB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325Function: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This mayinterfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization ofactivity at sites necessary for extracellular matrix destruction
Gene Wiki entry for PLGLB2 |
Genomic Views
for PLGLB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PLGLB2 gene promoter:
GATA-1 HNF-1A POU2F1 CUTL1 Pax-6 FOXI1 FOXO3a FOXO3b Cdc5 FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for PLGLB2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2PLGLB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P088045: view genomic region
(about GC identifiers)
Start:
|
88,045,921 bp from pter |
End:
|
88,058,995 bp from pter |
Size:
|
13,075 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.11 NT_022184.15
|
Proteins
for PLGLB2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325 (See
protein sequence)Recommended Name: Plasminogen-related protein B precursor Size: 96 amino acids; 10971 Da
Subcellular location: Secreted
Secondary accessions: Q580R1Explore the universe of human proteins at neXtProt for PLGLB2: NX_Q02325
REFSEQ proteins: NP_002656.1
ENSEMBL proteins: ENSP00000352458 ENSP00000386317 ENSP00000416351
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
-- | -- |
About this table
PLGLB2 for ontologies About GeneDecksing
Antibodies for PLGLB2:
Assays for PLGLB2: |
Protein
Domains/
Families
for PLGLB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PLGLB2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q02325ProtoNet protein and cluster: Q02325 UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325Similarity: Contains 1 PAN domain |
Gene Function
for PLGLB2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PLGB_HUMAN, Q02325Function: May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This mayinterfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization ofactivity at sites necessary for extracellular matrix destruction
|
Pathways & Interactions
for PLGLB2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PLGLB2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLGLB2
|
Drugs & Compounds
for PLGLB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PLGLB2
|
Transcripts
for PLGLB2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PLGLB2 gene: NM_002665.4 Additional cDNA sequence: AF075095.1 BC005379.1 BC022294.1 BC070296.1 BC107767.1 BC109248.2 M93143.2 19 DOTS entries: DT.86855200 DT.91938200 DT.121025805 DT.92414250 DT.121025724 DT.91671965 DT.40280299 DT.100777514 DT.91748454 DT.121024424 DT.121025836 DT.309339 DT.95078359 DT.121324519 DT.92044277 DT.95274717 DT.95361932 DT.97771437 DT.97776307 24/122 AceView cDNA sequences (see all 122): AV646001 H73621 BG566981 Z41205 H93627 BG568844 H59201 AA343648 BE504475 AF075095 AA916867 AV699135 BC070296 AI887874 AA382677 AV688060 BG568469 BG545296 AV647453 AA988082 AA732324 BG616458 BG566066 AA677935
 highest scoring ESTs for PLGLB2:AA716402 AA780316 AA927145 AF075095 AI023399 AI040617 AI635523 AV688060 BF126702 BG564999 Unigene Cluster for PLGLB2: Plasminogen-like B2 Hs.652169 [show with all ESTs]Unigene Representative Sequence: NM_002665
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359481(uc002ssl.2) ENST00000410086 ENST00000427160 ENST00000465361
|
Expression
for PLGLB2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PLGLB2 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching PLGLB2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 205871_at2, 3
|
U133-A |
5 |
1.00 |
0.39 |
-- |
-- |
BC005379 |
0.80 |
0.88 |
0.84 |
1 |
| 230120_s_at2, 3
|
U133-B |
2 |
0.27 |
0.50 |
-- |
-- |
AI088455 |
0.80 |
0.67 |
0.74 |
1 |
| 205871_at2
|
U133Plus2 |
5 |
1.00 |
0.39 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1558603_at2
|
U133Plus2 |
2 |
0.27 |
0.50 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230120_s_at2
|
U133Plus2 |
2 |
0.27 |
0.50 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTGACTCAA
SOURCE GeneReport for Unigene cluster: Hs.652169
SABiosciences Custom PCR Arrays for PLGLB2
|
Orthologs
for PLGLB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for PLGLB2 (if available) |
Paralogs
for PLGLB2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PLGLB2 gene
- PLGLB11 2 ENSG000001696592
PLGLB2 for paralogs About GeneDecksing
|
Genomic Variants
for PLGLB2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PLGLB2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for PLGLB2
6 CNVs: 7283 4294 89760 2399 50583 3374 |
Disorders & Mutations
for PLGLB2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PLGLB2 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: PLGLB2 (2 documents)
Export disorders and mutations for PLGLB2 gene to outside databases
|
Medical News
for PLGLB2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PLGLB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/14 PubMed articles for PLGLB2 gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with PLGLB2)- A plasminogen-related gene is expressed in cancer cells. (PubMed id 1379800)1, 2, 7 Weissbach L. and Treadwell B.V. (1992)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis. (PubMed id 1554698)1, 2 Ichinose A. (1992)
- Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis. (PubMed id 1986355)1, 3 Ichinose A.... Davie E.W. (1991)
- Expression of plasminogen-related gene B varies among normal tissues and increases in cancer tissues. (PubMed id 10069369)1, 7 Tateno T. and Ichinose A. (1999)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PLGLB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PLGLB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PLGLB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PLGLB2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PLGLB2 gene:
Search GeneIP for patents involving PLGLB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PLGLB2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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