Aliases &
Descriptions
for PNPLA7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| patatin-like phospholipase domain containing 71 2 | | chromosome 9 open reading frame 1111 | | NTE-R11 2 | | RP11-48C7.21 | | FLJ430701 2 | | patatin-like phospholipase domain-containing protein 72 | | FLJ442791 2 | | OTTHUMP000000227022 | | NTEL11 2 | | OTTHUMP000000227032 | | FLJ313181 2 | | EC 3.1.1.-3 | | C9orf1112 3 | | |
Export aliases for PNPLA7 gene to outside databasesPrevious GC identifers: GC09M139474 GC09M140354 |
Summaries
for PNPLA7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PNPLA7:
Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation andhave been induced by metabolic stimuli (Wilson et al., 2006 (PubMed 16799181)).(supplied by OMIM)
UniProtKB/Swiss-Prot: PLPL7_HUMAN, Q6ZV29Function: Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads todistal axonopathy (By similarity)
|
Genomic Views
for PNPLA7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PNPLA7 gene promoter:
p53 c-Myb USF1 deltaCREB CREB Max1 c-Myc GATA-1 SREBP-1a SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for PNPLA7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3PNPLA7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M109818: view genomic region
(about GC identifiers)
Start:
|
109,818,540 bp from pter |
End:
|
109,909,455 bp from pter |
Size:
|
90,916 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr9- 140,354,404-140,444,986 |
RefSeq DNA sequence:- NC_000009.11 NT_024000.16
|
Proteins
for PNPLA7 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PLPL7_HUMAN, Q6ZV29 (See
protein sequence)Recommended Name: Patatin-like phospholipase domain-containing protein 7 Size: 1317 amino acids; 145733 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential). Nucleus membrane; Single-pass membraneprotein (By similarity). Mitochondrion membrane; Single-pass membrane protein (By similarity). Lysosome membrane;Single-pass membrane protein (By similarity). Microsome membrane; Single-pass membrane protein (By similarity).Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions (By similarity)
Sequence caution: Sequence=BAB71033.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAI14579.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T364 Q658X0 Q658Y3 Q6ZTS1 Q86YU8 Q8TAY5 Q96N75 Q9H7N5Alternative splicing: 5 isoforms: Q6ZV29-1 Q6ZV29-2 Q6ZV29-3 Q6ZV29-4 Q6ZV29-5 Explore the universe of human proteins at neXtProt for PNPLA7: NX_Q6ZV29
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001092007.1 NP_689499.3
ENSEMBL proteins: ENSP00000360512 ENSP00000400582 ENSP00000360501 ENSP00000277531 ENSP00000360506 ENSP00000360505 ENSP00000384610
Human Recombinant Proteins
5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9): About this table
PNPLA7 for ontologies About GeneDecksing
Antibodies for PNPLA7:
Assays for PNPLA7: |
Protein
Domains/
Families
for PNPLA7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PNPLA7 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZV29ProtoNet protein and cluster: Q6ZV29 1 Blocks protein family: IPB000595 Cyclic nucleotide-binding domain
UniProtKB/Swiss-Prot: PLPL7_HUMAN, Q6ZV29Similarity: Belongs to the NTE familySimilarity: Contains 3 cyclic nucleotide-binding domainsSimilarity: Contains 1 patatin domain |
Gene Function
for PNPLA7 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PLPL7_HUMAN, Q6ZV29Function: Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads todistal axonopathy (By similarity)Enzyme Number (IUBMB): EC 3.1.1.-
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
About this table
PNPLA7 for ontologies About GeneDecksing
|
Pathways & Interactions
for PNPLA7 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PNPLA7 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for PNPLA7
SABiosciences Custom Pathway-Focused PCR Arrays for PNPLA7
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PNPLA7
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PNPLA7
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006629 | lipid metabolic process |
IEA | -- | | GO:0008152 | metabolic process |
IEA | -- |
About this table
PNPLA7 for ontologies About GeneDecksing
|
Drugs & Compounds
for PNPLA7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PNPLA7
|
Transcripts
for PNPLA7 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PNPLA7 gene (2 alternative transcripts): NM_001098537.1 NM_152286.3 Additional cDNA sequence: AK024443.1 AK055880.1 AK122590.1 AK125060.1 AK126267.1 AK127249.1 AK127340.1 AK297623.1 AK310060.1 AL832856.1 AL832944.1 BC025663.1 10 DOTS entries: DT.304123 DT.91832895 DT.101982754 DT.92009687 DT.101982753 DT.40196118 DT.95293772 DT.121161643 DT.304122 DT.91654192 24/420 AceView cDNA sequences (see all 420): F12765 AL389946 AA318133 AA450057 BM826247 BQ002520 AW401494 AI207845 BM856858 BM990623 BQ420985 AW157620 AK127340 AI473429 BM054738 AW403973 BM853105 BF725915 AW006898 BQ669076 BU681427 BM854574 AI241306 CB529512
 highest scoring ESTs for PNPLA7:AK125060 AK126267 AA278805 AA281145 AA300190 AA748017 AA769067 AI431482 AK024443 AK055880 Unigene Cluster for PNPLA7: Patatin-like phospholipase domain containing 7 Hs.294147 [show with all ESTs]Unigene Representative Sequence: AK122590
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PNPLA7 (see all 6)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PNPLA7
11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371457(uc004cnd.1 uc004cne.1) ENST00000492278 ENST00000487228
ENST00000434090 ENST00000371446(uc011mfa.1) ENST00000277531 ENST00000371451
ENST00000371450 ENST00000491019 ENST00000469998 ENST00000406427(uc010ncj.1 uc004cnf.2)
|
Expression
for PNPLA7 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PNPLA7 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching PNPLA7 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 63995_r_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.94 |
1.32 |
AW006898 |
0.60 |
1.00 |
0.82 |
1 |
| 48322_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.77 |
1.02 |
AA281145 |
0.60 |
1.00 |
0.82 |
1 |
| 63994_i_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.82 |
1.17 |
AW006898 |
0.60 |
1.00 |
0.82 |
1 |
| 67393_at2, 3
|
U95-E |
2 |
1.00 |
0.94 |
0.48 |
0.49 |
AA769067 |
0.60 |
1.00 |
0.82 |
1 |
| 236135_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BE676751 |
0.40 |
1.00 |
0.76 |
1 |
| 228383_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AK024443 |
0.60 |
1.00 |
0.82 |
1 |
| 236135_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 228383_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PNPLA7 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.294147
SABiosciences Custom PCR Arrays for PNPLA7
|
Orthologs
for PNPLA7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PNPLA7 gene from 5/12 species (see all 12)
About this table Species with no ortholog for PNPLA7
ENSEMBL Gene Tree for PNPLA7 (if available) |
Paralogs
for PNPLA7 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PNPLA7 gene
- PNPLA62
PNPLA7 for paralogs About GeneDecksing
|
Genomic Variants
for PNPLA7 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 9 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PNPLA7 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PNPLA7
2 Indels: 47677 47678 | | QIAGEN SeqTarget long-range PCR primers for resequencing PNPLA7 |
|
Disorders & Mutations
for PNPLA7 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PNPLA7 for disorders About GeneDecksing
OMIM: 612122
Export disorders and mutations for PNPLA7 gene to outside databases
|
Medical News
for PNPLA7 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PNPLA7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for PNPLA7 gene integrated from 7 sources:
(articles sorted by number of sources associating them with PNPLA7)- Mammalian patatin domain containing proteins: a famil y with diverse lipolytic activities involved in multiple biological functions. (PubMed id 19029121)1, 3 Kienesberger P.C....Zechner R. (2009)
- Characterization of the human patatin-like phospholipase family. (PubMed id 16799181)1, 3 Wilson P.A.... Crowther D.J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity. (PubMed id 12640454)1, 3 Winrow C.J....Barlow C. (2003)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PNPLA7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PNPLA7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PNPLA7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PNPLA7 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PNPLA7 gene:
Search GeneIP for patents involving PNPLA7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PNPLA7 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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