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POTEA Gene

protein-coding   GIFtS: 34

GC08P041671
POTE ankyrin domain family, member A
(Previous names: ANKRD26-like family A, member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: A26A1)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
POTE ankyrin domain family, member A1 2     A26A12 3
POTE81 2 3     ANKRD26-like family A member 12 3
POTE-81 2 3     POTE ankyrin domain family member A2
ANKRD26-like family A, member 11 2     cancer/testis antigen family 104, member 32
CT104.31 2     protein expressed in prostate, ovary, testis, and placenta 82
Prostate, ovary, testis-expressed protein on chromosome 82 3     

External Ids:    HGNC: 338931   Entrez Gene: 3404412   Ensembl: ENSG000002542187   UniProtKB: Q6S8J73   

Export aliases for POTEA gene to outside databases

Previous GC identifers: GC08P043268 GC08P043147


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for POTEA
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for POTEA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.1   Ensembl cytogenetic band:  8p11.1   HGNC cytogenetic band: 8p11.1

POTEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POTEA gene location

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P041671:  view genomic region     (about GC identifiers)

Start:
41,671,733 bp from pter
End:
41,742,486 bp from pter
Size:
70,754 bases
Orientation:
plus strand

1 alternative location:
Chr8+ 43,147,585-43,218,328     
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: POTEA_HUMAN, Q6S8J7 (See protein sequence)
Recommended Name: POTE ankyrin domain family member A  
Size: 498 amino acids; 56166 Da
Secondary accessions: A6ND17 A6ND71 Q6S8J6
Alternative splicing: 2 isoforms:  Q6S8J7-1   Q6S8J7-2   

Explore the universe of human proteins at neXtProt for POTEA: NX_Q6S8J7 

REFSEQ proteins (2 alternative transcripts): 
NP_001002920.1  NP_001005365.2  

Human Recombinant Proteins 
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Uscn ELISAs and CLIAs for POTEA 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

POTEA for domains           About GeneDecksing

2 InterPro domains/families:
 IPR002110 Ankyrin_rpt
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q6S8J7

ProtoNet protein and cluster: Q6S8J7

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: POTEA_HUMAN, Q6S8J7
Similarity: Belongs to the POTE family
Similarity: Contains 5 ANK repeats


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for POTEA
Sigma-Aldrich shRNA for POTEA
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): POTEA
OriGene shRNA RFP (see all 3): POTEA
OriGene basic RS shRNA (see all 3): POTEA
OriGene siRNA (see all 3): POTEA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POTEA 
miRNA:Sigma-Aldrich microRNA Mimics for POTEA
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POTEA 
Search SABiosciences for Assays for microRNAs that regulate POTEA

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): POTEA
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): POTEA
OriGene untagged cDNA clones in CMV expression vector (see all 2): POTEA
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): POTEA 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for POTEA 


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for POTEA 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POTEA

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for POTEA


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for POTEA
Sigma-Aldrich shRNA for POTEA
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): POTEA
OriGene shRNA RFP (see all 3): POTEA
OriGene basic RS shRNA (see all 3): POTEA
OriGene siRNA (see all 3): POTEA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POTEA 
miRNA: Sigma-Aldrich microRNA Mimics for POTEA
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POTEA 
Search SABiosciences for Assays for microRNAs that regulate POTEA
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): POTEA
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): POTEA
OriGene untagged cDNA clones in CMV expression vector (see all 2): POTEA
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): POTEA 
Primers: OriGene genome-wide validated SYBR primer pairs: POTEA
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for POTEA: PPH57820A

REFSEQ mRNAs for POTEA gene (2 alternative transcripts): 

NM_001002920.1  NM_001005365.2  

Additional cDNA sequence: 

AY462869.1 AY462870.1 

2 DOTS entries:

DT.102826485  DT.102826537 

3 AceView cDNA sequences:

AY462869 AY462870 NM_001002920 

Unigene Cluster for POTEA:

POTE ankyrin domain family, member A
Hs.531579
Unigene Representative Sequence: AY462869


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000522175 ENST00000519951

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

POTEA expression in normal and diseased human tissues

1 Data from GNF BioGPS
    About these images

POTEA gene expression
POTEA gene electronic northern expression
POTEA gene sage expression
About these images

CGAP SAGE TAG: CTAAGAATAG

SOURCE GeneReport for Unigene cluster: Hs.531579
Primers: OriGene genome-wide validated SYBR primer pairs: POTEA
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for POTEA: PPH57820A
    SABiosciences Custom PCR Arrays for POTEA 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for POTEA gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
POTEA1   -- POTE ankyrin domain family, member A 98.93(n)
97.99(a)
472754  XM_001140309.1  XP_001140309.1 
About this table        Species with no ortholog for POTEA

ENSEMBL Gene Tree for POTEA (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/568 NCBI SNPs in POTEA are shown (see all 568)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 8 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs8819071,2
C,F,A,H,43217541(+) CAATGC/TTTAGA 2 -- int19Minor allele frequency- T:0.15NS EA NA WA 430
rs9226321,2
C,F,O,A,43150374(+) TTGTGA/GATGTA 2 -- int119Minor allele frequency- N:0.00EA NA NS WA 1222
rs14715301,2
C,F,O,A,43155304(+) TATAGA/GGATAA 2 -- int114Minor allele frequency- G:0.15NS EA NA WA 618
rs14805071,2
C,F,A,43152918(+) AATTTA/GCCCTG 2 -- int110Minor allele frequency- G:0.08NS EA NA WA 468
rs14805081,2
C,H43157311(+) TTATAA/GTGATT 2 -- int13Minor allele frequency- G:0.00NA EA 252
rs16796511,2
C,43214505(-) AATTCA/GGAAAT 2 -- int10--------
rs16796521,2
C,F,H,43213665(-) gaaaaC/Tatatg 2 -- int110Minor allele frequency- T:0.01NS EA NA WA 430
rs18123461,2
C,F,A,43154704(+) ATTGGC/TAGTAT 2 -- int18Minor allele frequency- T:0.21NS NA WA 182
rs18250081,2
C,F,43169849(+) TTGCTA/GCATAG 2 -- int110Minor allele frequency- G:0.01NS EA NA WA 432
rs18250091,2
C,43192202(-) TGCTAA/CAAAGA 2 -- int10--------
About this table

HapMap Linkage Disequilibrium images for POTEA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for POTEA
     6 CNVs: 53780 29790 29791 59477 95398 52536
     1 Indel: 47541

QIAGEN SeqTarget long-range PCR primers for resequencing POTEA 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

POTEA for disorders           About GeneDecksing

OMIM: 608915


Export disorders and mutations for POTEA gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

4 PubMed articles for POTEA gene integrated from 7 sources:
(articles sorted by number of sources associating them with POTEA)
  1. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. (PubMed id 15276201)1, 2 Bera T.K.... Pastan I. (2004)
  2. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. (PubMed id 16364570)1 Hahn Y.... Lee B. (2006)
  3. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
  4. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. (PubMed id 12475935)1 Bera T.K.... Pastan I. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 340441 HGNC: 33893 AceView: POTE8 Ensembl:ENSG00000254218 euGenes: HUgn340441
ECgene: POTEA H-InvDB: POTEA

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for POTEA gene:
Search GeneIP for patents involving POTEA

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 Predesigned and custom siRNAs for POTEA Antibodies for POTEA
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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of POTEA
 SeqTarget long-range PCR primers for resequencing POTEA
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of POTEA
 GenScript Custom Purified and Recombinant Proteins Services for POTEA GenScript cDNA clones with any tag delivered in your preferred vector for POTEA
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 ELISAs and CLIAs for POTEA
       

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