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PRR23A Gene

protein-coding   GIFtS: 30

GC03M136098
proline rich 23A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for PRR23A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
proline rich 23A1 2
UPF0572 protein ENSP000003726502
proline-rich protein 23C2
proline-rich protein 23A2

External Ids:    HGNC: 371721   Entrez Gene: 7296272   Ensembl: ENSG000002062607   UniProtKB: A6NEV13   

Export aliases for PRR23A gene to outside databases

Previous GC identifers: GC03M140211 GC03M138722


Summaries
for PRR23A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for PRR23A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PRR23A
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PRR23A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PRR23A 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q22.3

PRR23A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRR23A gene location

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M136098:  view genomic region     (about GC identifiers)

Start:
 136,098,241 bp from pter
End:
 136,100,547 bp from pter
Size:
 2,307 bases
Orientation:
 minus strand

1 alternative location:
Chr3- 138,722,804-138,725,110     
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  

Proteins
for PRR23A gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: PR23A_HUMAN, A6NEV1 (See protein sequence)
Recommended Name: Proline-rich protein 23A  
Size: 266 amino acids; 28155 Da

Explore the universe of human proteins at neXtProt for PRR23A: NX_A6NEV1 

REFSEQ proteins: NP_001128131.1  

ENSEMBL proteins: 
ENSP00000372649 


Human Recombinant Proteins 
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Protein Domains/
Families
for PRR23A gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
PRR23A for domains           About GeneDecksing

1 InterPro domain/family:
 IPR018903 UPF0572

Graphical View of Domain Structure for InterPro Entry A6NEV1

ProtoNet protein and cluster: A6NEV1

UniProtKB/Swiss-Prot: PR23A_HUMAN, A6NEV1
Similarity: Belongs to the PRR23 family


Gene Function
for PRR23A gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich siRNA for PRR23A
Sigma-Aldrich shRNA for PRR23A
OriGene 29mer shRNA kits in GFP-retroviral vector: PRR23A
OriGene shRNA RFP: PRR23A
OriGene basic RS shRNA: PRR23A
OriGene siRNA: PRR23A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRR23A 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRR23A 
Search SABiosciences for Assays for microRNAs that regulate PRR23A

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PRR23A
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for PRR23A 


Pathways & Interactions
for PRR23A gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for PRR23A 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRR23A

Drugs & Compounds
for PRR23A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRR23A


Transcripts
for PRR23A gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for PRR23A
Sigma-Aldrich shRNA for PRR23A
OriGene 29mer shRNA kits in GFP-retroviral vector: PRR23A
OriGene shRNA RFP: PRR23A
OriGene basic RS shRNA: PRR23A
OriGene siRNA: PRR23A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PRR23A 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PRR23A 
Search SABiosciences for Assays for microRNAs that regulate PRR23A
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PRR23A
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for PRR23A 
Primers: OriGene genome-wide validated SYBR primer pairs: PRR23A
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for PRR23A

REFSEQ mRNAs for PRR23A gene: 

NM_001134659.1  

1 DOTS entry:

DT.300053 

Unigene Cluster for PRR23A:

Proline rich 23A
Hs.121314  [show with all ESTs]
Unigene Representative Sequence: NM_001134659


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000383163(uc011bms.1)

Expression
for PRR23A gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PRR23A expression in normal and diseased human tissues

1 Data from GNF BioGPS
    About these images

PRR23A gene expression
PRR23A gene electronic northern expression
PRR23A gene sage expression
About these images

CGAP SAGE TAG: ACACAAAGTT

SOURCE GeneReport for Unigene cluster: Hs.121314
Primers: OriGene genome-wide validated SYBR primer pairs: PRR23A
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for PRR23A
    SABiosciences Custom PCR Arrays for PRR23A 


Orthologs
for PRR23A gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for PRR23A gene from 4 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC6111311   -- hypothetical protein LOC611131 73.53(n)
57.61(a)		 611131  XM_862887.1  XP_867980.1 
chimpanzee
(Pan troglodytes)		 LOC7436051   -- hypothetical protein LOC743605 98.99(n)
98.49(a)		 743605  XM_001158013.1  XP_001158013.1 
cow
(Bos taurus)		 LOC6166681   -- hypothetical LOC616668 69.77(n)
54.26(a)		 616668  XM_868750.1  XP_873843.1 
mouse
(Mus musculus)		 Prr23a5
2410012M07Rik1		 9 (51.41 cM)5
 proline rich 23A5
RIKEN cDNA 2410012M07 gene1		 64.84(n)1
49.37(a)1		 719791  XM_486251.31  XP_486251.11 
About this table        Species with no ortholog for PRR23A

ENSEMBL Gene Tree for PRR23A (if available)

Paralogs
for PRR23A gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for PRR23A gene
PRR23B2  PRR23C2  

PRR23A for paralogs           About GeneDecksing



Genomic Variants
for PRR23A gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/41 NCBI SNPs in PRR23A are shown (see all 41)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs10101871,2
--138724173(-) TTTGGA/GTGggt 1 -- ut310--------
rs15538771,2
C,F,O,H,138723826(-) AGTTAC/GGAATT 1 -- ut3121Minor allele frequency- G:0.10NS EA NA WA 1202
rs48943341,2
C,H,138725245(+) CGGGGC/AGAGTC 1 -- ng518Minor allele frequency- A:0.09NA EA WA 172
rs67882321,2
C,F,A,H,138722621(+) ctcatC/Tgtgcc 1 -- ng318Minor allele frequency- T:0.12NA WA 138
rs67995771,2
C,F,A,H,138722538(+) tttttT/Aaattt 1 -- ng313Minor allele frequency- A:0.25NA 8
rs109352961,2
C,F,A,H,138726187(+) taagtG/Aagaac 1 -- ng516Minor allele frequency- A:0.14NS EA NA WA 490
rs119241881,2
C,F,A,H,138724757(+) GCAGAG/CGAGTC 2 /S syn1 ref15Minor allele frequency- C:0.17NA 12
rs126341501,2
C,F,H,138722575(+) agtccC/Aagtta 1 -- ng314Minor allele frequency- A:0.20NA EA WA 168
rs126370881,2
C,H138722737(+) ATCTTT/CAGAAG 1 -- ng314Minor allele frequency- C:0.00NS EA 384
rs130869251,2
C,A138725668(+) AATGTC/TTCTTC 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for PRR23A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for PRR23A: --

QIAGEN SeqTarget long-range PCR primers for resequencing PRR23A 

Disorders & Mutations
for PRR23A gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for PRR23A gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for PRR23A gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

1 PubMed article for PRR23A gene integrated from 7 sources:
(articles sorted by number of sources associating them with PRR23A)
  1. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)

External Searches for PRR23A gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing PRR23A gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 729627 HGNC: 37172 Ensembl:ENSG00000206260 euGenes: HUgn729627 ECgene: PRR23A
H-InvDB: PRR23A

Other Databases showing PRR23A gene

(According to HUGE)
About This Section
   --

Specialized Databases showing PRR23A gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
   --

Intellectual Property
for PRR23A gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for PRR23A gene:
Search GeneIP for patents involving PRR23A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for PRR23A gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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