Aliases &
Descriptions
for PYDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| PYD (pyrin domain) containing 11 2 | | PAAD-only protein 12 3 | | ASC21 2 3 | | PYC12 3 | | POP11 2 3 | | pyrin-domain containing protein 12 | | pyrin domain containing 11 2 | | pyrin domain-containing protein 12 | | Pyrin-only protein 12 3 | | ASCI3 |
Export aliases for PYDC1 gene to outside databasesPrevious GC identifers: GC16M031135 GC16M031227 |
Summaries
for PYDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PYDC1_HUMAN, Q8WXC3Function: Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates itsability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activityof NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-Bactivation by cytokines and LPS
|
Genomic Views
for PYDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PYDC1 gene promoter:
NF-kappaB1 NF-kappaB p53 PPAR-gamma2 PPAR-gamma1 HNF-4alpha2 COUP-TF1 RSRFC4 STAT1alpha STAT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PYDC1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PYDC1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2PYDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M028788: view genomic region
(about GC identifiers)
Start:
|
28,788,912 bp from pter |
End:
|
28,790,027 bp from pter |
Size:
|
1,116 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr16- 31,227,283-31,228,414 |
RefSeq DNA sequence:- NC_000016.9 NT_010393.16
|
Proteins
for PYDC1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PYDC1_HUMAN, Q8WXC3 (See
protein sequence)Recommended Name: Pyrin domain-containing protein 1 Size: 89 amino acids; 10107 Da
Subunit: Interacts with PYCARD/ASC
Subcellular location: Cytoplasm
PDB structures from  and Proteopedia  :2HM2 (3D)
Secondary accessions: B2R8L4 Q8NFP8Explore the universe of human proteins at neXtProt for PYDC1: NX_Q8WXC3
Post-translational modifications:
Phosphorylated1
REFSEQ proteins: NP_690865.1
ENSEMBL proteins: ENSP00000304336
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PYDC1 for ontologies About GeneDecksing
Antibodies for PYDC1:
Assays for PYDC1: |
Protein
Domains/
Families
for PYDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PYDC1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXC3ProtoNet protein and cluster: Q8WXC3 UniProtKB/Swiss-Prot: PYDC1_HUMAN, Q8WXC3Similarity: Contains 1 DAPIN domain |
Gene Function
for PYDC1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PYDC1_HUMAN, Q8WXC3Function: Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates itsability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activityof NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-Bactivation by cytokines and LPS
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
PYDC1 for ontologies About GeneDecksing
|
Pathways & Interactions
for PYDC1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PYDC1 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for PYDC1):  | hsa04621 NOD-like receptor signaling pathway |
SABiosciences Pathway-Focused PCR Array including PYDC1: PAHS-097A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PYDC1
3 Interacting proteins for PYDC1 (ENSP000003043363) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
PYDC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PYDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PYDC1
|
Transcripts
for PYDC1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PYDC1 gene: NM_152901.2 Additional cDNA sequence: AF086332.1 AF454669.1 AF467809.1 AK313418.1 AY163727.1 BC105033.1 BC105035.1 1 DOTS entry: DT.97807510 11 AceView cDNA sequences: AF086332 BF510919 BX100966 CA489551 W73523 AI631452 AF467809 BG212907 NM_152901 AF454669 W73558
 highest scoring ESTs for PYDC1:W73523 AF086332 AF454669 AF467809 AI631452 BF510919 BX100966 CA489551 W73558 NM_152901 Unigene Cluster for PYDC1: PYD (pyrin domain) containing 1 Hs.58314 [show with all ESTs]Unigene Representative Sequence: CA489551
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000302964(uc002ebo.2)
|
Expression
for PYDC1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PYDC1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching PYDC1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 46088_at2, 3
|
U95-B |
1 |
0.50 |
1.00 |
1.00 |
1.00 |
W73523 |
1.00 |
1.00 |
1.00 |
1 |
| 243722_at2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
W73523 |
1.00 |
1.00 |
1.00 |
1 |
| 243722_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PYDC1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCAGACTTTA
SOURCE GeneReport for Unigene cluster: Hs.58314
UniProtKB/Swiss-Prot: PYDC1_HUMAN, Q8WXC3Tissue specificity: Predominantly expressed in monocytes, macrophages and granulocytes
SABiosciences Expression via Pathway-Focused PCR Array including PYDC1: PAHS-097A
|
Orthologs
for PYDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PYDC1 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
PYDC11 |
-- |
PYD (pyrin domain) containing 1 |
98.88(n)
100(a) |
742490 XM_001158748.1 XP_001158748.1 |
About this table Species with no ortholog for PYDC1
ENSEMBL Gene Tree for PYDC1 (if available) |
Paralogs
for PYDC1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PYDC1 gene
- PYCARD2
PYDC1 for paralogs About GeneDecksing
|
Genomic Variants
for PYDC1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing PYDC1 |
|
Disorders & Mutations
for PYDC1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for PYDC1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PYDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for PYDC1 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with PYDC1)- Structure and dynamics of ASC2, a pyrin domain-only protein that regulates inflammatory signaling. (PubMed id 16905547)1, 2, 3 Natarajan A.... Hill J.M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation. (PubMed id 12656673)1, 2 Stehlik C....Reed J.C. (2003)
- PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB. (PubMed id 11786556)2, 3 Manji G.A....Bertin J. (2002)
- RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2. (PubMed id 18031289)1 Son Y.L....Lee Y.C. (2008)
- Determining the 3D structure of human ASC2 protein involved in apoptosis and inflammation. (PubMed id 16403450)1 Espejo F. and Patarroyo M.E. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. (PubMed id 11166558)1 Pawl/owski K....Godzik A. (2001)
- Personalized medicine in psoriasis: developing a geno mic classifier to predict histological response to Alefacept. (PubMed id 20152045)7 SuA!rez-FariA+as M....Lowes M.A. (2010)
|
External Searches for PYDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PYDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PYDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PYDC1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PYDC1 gene:
Search GeneIP for patents involving PYDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PYDC1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for PYDC1 |
| |  |  |  |  | | | | |
 | | |
|
|
