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TLR8 Gene

protein-coding GIFtS: 59

GC0XP010691

toll-like receptor 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
toll-like receptor 8¹ ²
CD288¹ ²
MGC119599²
MGC119600²
CD288 antigen³

External Ids:	HGNC: 15632¹	Entrez Gene: 51311²	Ensembl: ENSG00000101916⁷	UniProtKB: Q9NR97³

Export aliases for TLR8 gene to outside databases

Previous GC identifers: GC0XP012117 GC0XP011690 GC0XP012221 GC0XP012286 GC0XP012684 GC0XP012834

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR8:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in

pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share

structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are

expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective

immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and

peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. (provided by

RefSeq)

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97

Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response

against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6,

leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

Gene Wiki entry for TLR8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TLR8 gene promoter:
         NF-kappaB1   IRF-7A   NF-kappaB   p53   POU2F1   CUTL1   HOXA9B   Meis-1   ARP-1   GATA-1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TLR8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22

TLR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR8 gene location

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP010691: view genomic region (about GC identifiers)

Start:	10,691,356 bp from pter
End:	10,708,478 bp from pter
Size:	17,123 bases
Orientation:	plus strand

1 alternative location:

ChrX+ 12,924,739-12,941,288

RefSeq DNA sequence:

NC_000023.10 NT_167197.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97 (See protein sequence)

Recommended Name: Toll-like receptor 8 precursor

Size: 1041 amino acids; 119828 Da

Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)

Secondary accessions: B3Y654 Q495P4 Q6UXL6 Q9NYG9

Explore the universe of human proteins at neXtProt for TLR8: NX_Q9NR97

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_619542.1

ENSEMBL proteins:

ENSP00000218032 ENSP00000312082

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for TLR8
	Novus Biologicals Protein for TLR8
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010008	endosome membrane	TAS	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IC	12032557
GO:0031224	intrinsic to membrane	--	--

About this table

TLR8 for ontologies About GeneDecksing

Antibodies for TLR8:

	Millipore Mono- and Polyclonal Antibodies for the study of TLR8
	Sigma-Aldrich Antibodies for TLR8
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TLR8
	GenScript Custom Superior Antibodies Services for TLR8
	Novus Biologicals Antibodies for TLR8
	Browse antibodies at Epitomics

Assays for TLR8:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TLR8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TLR8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TLR8 for domains About GeneDecksing

5 InterPro domains/families:

IPR000483 Cys-rich_flank_reg_C

IPR001611 Leu-rich_rpt

IPR000157 Toll-Interleukin_rcpt

IPR003591 Leu-rich_rpt_typical-subtyp

IPR015764 Toll-like_rcpt8_LRR-contain

Graphical View of Domain Structure for InterPro Entry Q9NR97

ProtoNet protein and cluster: Q9NR97

2 Blocks protein families:

IPB000157 TIR domain

IPB000483 Cysteine-rich flanking region

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97

Similarity: Belongs to the Toll-like receptor family

Similarity: Contains 24 LRR (leucine-rich) repeats

Similarity: Contains 1 TIR domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97

Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response

against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6,

leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLR8 Sigma-Aldrich shRNA for TLR8
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TLR8 OriGene shRNA RFP (see all 2): TLR8 OriGene basic RS shRNA (see all 2): TLR8 OriGene siRNA (see all 2): TLR8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLR8

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLR8
		Search SABiosciences for Assays for microRNAs that regulate TLR8

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TLR8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLR8 OriGene untagged cDNA clones in CMV expression vector: TLR8 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TLR8
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TLR8

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	16123302
GO:0003723	RNA binding	TAS	16123302
GO:0003725	double-stranded RNA binding	IDA	16111635
GO:0003727	single-stranded RNA binding	IDA	14976262
GO:0004872	receptor activity	NAS	12032557

About this table

TLR8 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tlr8):

hematopoietic system

homeostasis/metabolism

immune system

renal/urinary system

TLR8 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

TLR8 for pathways About GeneDecksing

1 Millipore Pathway for TLR8

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

5/8 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for TLR8 (see all 8)

	NF-κB Signaling
	Toll-like Receptor Signaling
	Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
	Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
	Communication between Innate and Adaptive Immune Cells

1 Kegg Pathway (Kegg details for TLR8):

hsa04620 Toll-like receptor signaling pathway

SABiosciences Pathway-Focused PCR Arrays including TLR8 (see all 4): PAHS-018A PAHS-025A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TLR8

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TLR8

2 Interacting proteins for TLR8 (ENSP00000312082³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TLR7	ENSP00000370034³	STRING: ENSP00000370034
--	ENSP00000323890³	STRING: ENSP00000323890

About this table

5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007249	I-kappaB kinase/NF-kappaB cascade	IDA	12032557
GO:0009615	response to virus	IDA	12032557
GO:0016064	immunoglobulin mediated immune response	TAS	16123302

About this table

TLR8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

TLR8 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Enzo Life Sciences drugs & compounds for TLR8

Browse Tocris compounds for TLR8
4 Novoseek chemical compound relationships for TLR8 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
resiquimod	92.4	1	14638493 (1)
imidazoquinoline	89.2	7	17868034 (2), 18031250 (1), 18439678 (1), 17082568 (1) (see all 5)
imiquimod	75.5	8	18439678 (2), 19017992 (1), 19164127 (1), 16728430 (1)
poly(i-c)	59.7	1	14530316 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLR8 Sigma-Aldrich shRNA for TLR8
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TLR8 OriGene shRNA RFP (see all 2): TLR8 OriGene basic RS shRNA (see all 2): TLR8 OriGene siRNA (see all 2): TLR8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLR8

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLR8
		Search SABiosciences for Assays for microRNAs that regulate TLR8

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TLR8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLR8 OriGene untagged cDNA clones in CMV expression vector: TLR8 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TLR8

Primers:		OriGene genome-wide validated SYBR primer pairs: TLR8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TLR8: PPH01801A

REFSEQ mRNAs for TLR8 gene:

NM_138636.4

Additional cDNA sequence:

AB445666.1 AF245703.1 AF246971.1 AK075117.1 AK297024.1 AK307562.1 AK314240.1 AY358296.1

BC101074.1 BC101075.2 BC101076.2 BC101077.1 CR596887.1

2 DOTS entries:

DT.109879 DT.91707993

24/28 AceView cDNA sequences (see all 28):

AI261982 AI424196 AF245703 NM_138636 BQ448547 AK075117 AA740964 BE857344

NM_016610 CR596887 AA568781 AL544223 AA922616 AY358296 BX106790 AA042875

AF246971 CA310384 CD365421 C01399 AI890649 AA707766 AW872374 AA042999

highest scoring ESTs for TLR8:

AA042999 AA042875 AA568781 AA707766 AA740964 AA922616 AF245703 AF246971 AI261982 AI424196

Unigene Cluster for TLR8:

Toll-like receptor 8

Hs.660543 [show with all ESTs]

Unigene Representative Sequence: NM_138636

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TLR8

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b
SP1:					-				-
SP2:					-		-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for TLR8
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000218032(uc004cve.2 uc004cvd.2) ENST00000311912

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TLR8 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching TLR8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54495_at²^{, 3}	U95-B	1	0.75	1.00	1.00	1.00	AA042999	0.80	0.80	0.80	1
220832_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016610	0.40	0.67	0.55	1
229560_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW872374	0.60	0.75	0.68	1
220832_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229560_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

TLR8 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

TLR8 gene electronic northern expression

About these images

CGAP SAGE TAG: GTTATATTAT

SOURCE GeneReport for Unigene cluster: Hs.660543

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97

Tissue specificity: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+

immature dendritic cells

Primers:		OriGene genome-wide validated SYBR primer pairs: TLR8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TLR8: PPH01801A

SABiosciences Expression via Pathway-Focused PCR Arrays including TLR8 (see all 4): PAHS-018A PAHS-025A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TLR8 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	TLR8¹	--	toll-like receptor 8	99.39(n) 99.62(a)	473522 XM_528893.2 XP_528893.2
cow (Bos taurus)	TLR8¹	--	toll-like receptor 8	80.51(n) 74.58(a)	532262 NM_001033937.1 NP_001029109.1
mouse (Mus musculus)	Tlr8^{1 , 5}	X (78.29 cM)⁵	toll-like receptor 8^{1, 5}	76.76(n)¹ 71.84(a)¹	170744¹ NM_133212.2¹ NP_573475.2¹ AA681338⁵ AY035890⁵ (see all 6)
zebrafish (Danio rerio)	tlr8a¹	--	toll-like receptor 8a	51.57(n) 44.98(a)	403137 XM_001920559.1 XP_001920594.1

About this table Species with no ortholog for TLR8

ENSEMBL Gene Tree for TLR8 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TLR8 gene

ENSG00000173366² CD180² LRRC32² TLR7² TLR3² TLR9² LRRC33² TLR4²

TLR8 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1013150^1,2	C,F,A,H,	12932441(+)	`TGGAAA/GATCCT`	1	--	int¹		14	NS EA NA EU WA	736
rs1013151^1,2	C,F,A,H,	12932531(+)	`cagaaT/Ctctct`	1	--	int¹		12	NA EU MN NS EA WA	693
rs1548731^1,2	C,F,A,	12927947(+)	`gtctgT/Caaagc`	1	--	int¹		22	EA NA EU NS MN	1389
rs2109134^1,2	C,F,O,A,H,	12927186(+)	`CCAGGA/TTCCAT`	1	--	int¹		22	NA EA EU NS WA	1198
rs2109135^1,2	C,H,	12939928(+)	`TGGGAC/TCCGGG`	4	D	syn¹ ref¹ ese³		13	NA EA NS WA	680
rs2159377^1,2	C,F,A,	12937513(+)	`ACAGAC/TGGGGC`	4	D	ref¹ syn¹ ese³		15	NA EA EU NS	981
rs2286626^1,2	H	12928764(+)	`GCGAAT/CGAGTT`	1	--	int¹		4	NS EA	420
rs2407992^1,2	C,F,O,A,H,	12939112(+)	`AGGCTC/GAAGCA`	4	L	syn¹ ref¹ ese³		17	NA EU NS EA WA	917
rs2625416^1,2	H	12941155(-)	`AAGCTA/GTCCAT`	2	--	ut3¹		4	NS EA	418
rs3747414^1,2	C,F,A,H,	12939412(+)	`ACAATA/CAACAA`	4	I	syn¹ ref¹		14	NA EU NS EA WA	659

About this table

HapMap Linkage Disequilibrium images for TLR8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TLR8: --

QIAGEN SeqTarget long-range PCR primers for resequencing TLR8

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TLR8 for disorders About GeneDecksing

OMIM: 300366

6 Novoseek disease relationships for TLR8 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
virus infection	46	5	14530316 (1), 19644151 (1), 19164127 (1), 17964520 (1)
inflammation	20.7	1	14530316 (1)
influenza	1.34	1	16959331 (1)
necrosis	0	2	19527497 (1), 17548497 (1)
tumors	0	5	20237413 (3), 19527497 (1), 17548497 (1)
cancer	0	4	18176600 (2), 19848448 (1), 17476348 (1)

About this table

Locus Specific Mutation Databases (LSDB): TLR8
Human Gene Mutation Database (HGMD): TLR8
Human Genome Epidemiology (HuGE) Navigator: TLR8 (21 documents)

Export disorders and mutations for TLR8 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

Course of HIV Infection Influenced by Toll-like Receptors: Presented at ECCMID

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/159 PubMed articles for TLR8 gene, integrated from 7 sources (see all 159):
(articles sorted by number of sources associating them with TLR8)

Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)^{1, 2, 3, 7} Du X.... Beutler B. (2000)
Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)^{1, 2} Nakajima T....Kimura A. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. (PubMed id 11022120)^{1, 2} Chuang T.-H. and Ulevitch R.J. (2000)
The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists. (PubMed id 17868034)^{1, 7} Rajagopal R....Wightman P.D. (2008)
TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation. (PubMed id 19164127)^{1, 7} LarangAc A....Kerdine-RAPmer S. (2009)
A five-amino-acid motif in the undefined region of th e TLR8 ectodomain is required for species-specific ligand recognition. (PubMed id 20004021)^{1, 7} Liu J....Chuang T.H. (2010)
Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. (PubMed id 18682521)^{1, 7} Moller-Larsen S....Borglum A.D. (2008)
Triggering of TLR7 and TLR8 expressed by human lung c ancer cells induces cell survival and chemoresistance. (PubMed id 20237413)^{1, 7} Cherfils-Vicini J....Cremer I. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51311	HGNC: 15632	AceView: TLR8	Ensembl:ENSG00000101916	euGenes: HUgn51311
ECgene: TLR8	Kegg: 51311	H-InvDB: TLR8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for TLR8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for TLR8 gene:
Search GeneIP for patents involving TLR8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TLR8		Antibodies for TLR8
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLR8
	SeqTarget long-range PCR primers for resequencing TLR8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLR8

	GenScript Custom Purified and Recombinant Proteins Services for TLR8		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TLR8
	GenScript Custom Assay Services for TLR8		GenScript Custom Superior Antibodies Services for TLR8
	GenScript Custom overexpressing Cell Line Services for TLR8		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TLR8 promoter
	Search Chromatin IP Primers for TLR8
	RT² qPCR Primer Assay for TLR8
	GNC Network for TLR8
	Search for Assays for microRNAs that regulate TLR8
	SABiosciences PCR Arrays including TLR8

Search Tocris compounds for TLR8

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs for TLR8
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for TLR8

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TLR8 gene at Home site.

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TLR8 Gene

protein-coding GIFtS: 59

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TLR8 Gene

protein-coding GIFtS: 59

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for TLR8 gene

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for TLR8 gene

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for TLR8 gene

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for TLR8 gene

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