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TLR8 Gene

protein-coding   GIFtS: 59

GC0XP010691
toll-like receptor 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
toll-like receptor 81 2
CD2881 2
MGC1195992
MGC1196002
CD288 antigen3

External Ids:    HGNC: 156321   Entrez Gene: 513112   Ensembl: ENSG000001019167   UniProtKB: Q9NR973   

Export aliases for TLR8 gene to outside databases

Previous GC identifers: GC0XP012117 GC0XP011690 GC0XP012221 GC0XP012286 GC0XP012684 GC0XP012834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR8:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share
structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective
immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and
peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. (provided by
RefSeq)

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6,
leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

Gene Wiki entry for TLR8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR8 gene promoter:
         NF-kappaB1   IRF-7A   NF-kappaB   p53   POU2F1   CUTL1   HOXA9B   Meis-1   ARP-1   GATA-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TLR8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22

TLR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR8 gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP010691:  view genomic region     (about GC identifiers)

Start:
10,691,356 bp from pter
End:
10,708,478 bp from pter
Size:
17,123 bases
Orientation:
plus strand

1 alternative location:
ChrX+ 12,924,739-12,941,288     
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97 (See protein sequence)
Recommended Name: Toll-like receptor 8 precursor  
Size: 1041 amino acids; 119828 Da
Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: B3Y654 Q495P4 Q6UXL6 Q9NYG9

Explore the universe of human proteins at neXtProt for TLR8: NX_Q9NR97 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_619542.1  

    ENSEMBL proteins: 
    ENSP00000218032 ENSP00000312082 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for TLR8 
    Novus Biologicals Protein for TLR8
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010008 endosome membrane TAS--
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IC12032557
    GO:0031224 intrinsic to membrane ----
    About this table

    TLR8 for ontologies           About GeneDecksing



    Antibodies for TLR8: 
    Millipore Mono- and Polyclonal Antibodies for the study of TLR8
    Sigma-Aldrich Antibodies for TLR8
    Browse R&D Systems for Antibodies
    OriGene Antibodies: TLR8
    GenScript Custom Superior Antibodies Services for TLR8 
    Novus Biologicals Antibodies for TLR8
    Browse antibodies at Epitomics

    Assays for TLR8: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLR8 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TLR8 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TLR8 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 Toll-Interleukin_rcpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR015764 Toll-like_rcpt8_LRR-contain

    Graphical View of Domain Structure for InterPro Entry Q9NR97

    ProtoNet protein and cluster: Q9NR97

    2 Blocks protein families:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 24 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6,
    leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLR8
    Sigma-Aldrich shRNA for TLR8
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TLR8
    OriGene shRNA RFP (see all 2): TLR8
    OriGene basic RS shRNA (see all 2): TLR8
    OriGene siRNA (see all 2): TLR8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLR8 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLR8 
    Search SABiosciences for Assays for microRNAs that regulate TLR8

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TLR8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLR8
    OriGene untagged cDNA clones in CMV expression vector: TLR8
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TLR8 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TLR8 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IDA16123302
    GO:0003723 RNA binding TAS16123302
    GO:0003725 double-stranded RNA binding IDA16111635
    GO:0003727 single-stranded RNA binding IDA14976262
    GO:0004872 receptor activity NAS12032557
    About this table

    TLR8 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tlr8):

    hematopoietic systemhomeostasis/metabolismimmune systemrenal/urinary system

    TLR8 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TLR8 for pathways           About GeneDecksing

    1 Millipore Pathway for TLR8
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/8 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  TLR8 (see all 8)
        NF-κB Signaling
    Toll-like Receptor Signaling
    Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
    Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
    Communication between Innate and Adaptive Immune Cells

    1 Kegg Pathway  (Kegg details for TLR8):
        hsa04620 Toll-like receptor signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including TLR8 (see all 4): PAHS-018A PAHS-025A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TLR8
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR8

    2 Interacting proteins for TLR8 (ENSP000003120823) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TLR7ENSP000003700343STRING: ENSP00000370034
    --ENSP000003238903STRING: ENSP00000323890
    About this table

    5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954 inflammatory response IEA--
    GO:0007165 signal transduction IEA--
    GO:0007249 I-kappaB kinase/NF-kappaB cascade IDA12032557
    GO:0009615 response to virus IDA12032557
    GO:0016064 immunoglobulin mediated immune response TAS16123302
    About this table

    TLR8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TLR8 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Enzo Life Sciences drugs & compounds for TLR8

    Browse Tocris compounds for TLR8
    4 Novoseek chemical compound relationships for TLR8 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    resiquimod 92.4 1 14638493 (1)
    imidazoquinoline 89.2 7 17868034 (2), 18031250 (1), 18439678 (1), 17082568 (1) (see all 5)
    imiquimod 75.5 8 18439678 (2), 19017992 (1), 19164127 (1), 16728430 (1)
    poly(i-c) 59.7 1 14530316 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLR8
    Sigma-Aldrich shRNA for TLR8
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TLR8
    OriGene shRNA RFP (see all 2): TLR8
    OriGene basic RS shRNA (see all 2): TLR8
    OriGene siRNA (see all 2): TLR8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLR8 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLR8 
    Search SABiosciences for Assays for microRNAs that regulate TLR8
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TLR8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLR8
    OriGene untagged cDNA clones in CMV expression vector: TLR8
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TLR8 
    Primers: OriGene genome-wide validated SYBR primer pairs: TLR8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TLR8: PPH01801A

    REFSEQ mRNAs for TLR8 gene: 

    NM_138636.4  

    Additional cDNA sequence: 

    AB445666.1 AF245703.1 AF246971.1 AK075117.1 AK297024.1 AK307562.1 AK314240.1 AY358296.1 
    BC101074.1 BC101075.2 BC101076.2 BC101077.1 CR596887.1 

    2 DOTS entries:

    DT.109879  DT.91707993 

    24/28 AceView cDNA sequences (see all 28):

    AI261982 AI424196 AF245703 NM_138636 BQ448547 AK075117 AA740964 BE857344 
    NM_016610 CR596887 AA568781 AL544223 AA922616 AY358296 BX106790 AA042875 
    AF246971 CA310384 CD365421 C01399 AI890649 AA707766 AW872374 AA042999 

    highest scoring ESTs for TLR8:

    AA042999 AA042875 AA568781 AA707766 AA740964 AA922616 AF245703 AF246971 AI261982 AI424196 

    Unigene Cluster for TLR8:

    Toll-like receptor 8
    Hs.660543  [show with all ESTs]
    Unigene Representative Sequence: NM_138636


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TLR8

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
    SP1:              -           -               
    SP2:              -     -     -               
    SP3:                                          

    About this scheme

    ECgene alternative splicing isoforms for TLR8
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218032(uc004cve.2 uc004cvd.2) ENST00000311912

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TLR8 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching TLR8 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    54495_at2, 3 U95-B 1 0.75 1.00 1.00 1.00 AA042999 0.80 0.80 0.80 1
    220832_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016610 0.40 0.67 0.55 1
    229560_at2, 3 U133-B 1 1.00 1.00 -- -- AW872374 0.60 0.75 0.68 1
    220832_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    229560_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    TLR8 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TLR8 gene expression
    TLR8 gene electronic northern expression
    TLR8 gene sage expression
    About these images

    CGAP SAGE TAG: GTTATATTAT

    SOURCE GeneReport for Unigene cluster: Hs.660543

    UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97
    Tissue specificity: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+
    immature dendritic cells

    Primers: OriGene genome-wide validated SYBR primer pairs: TLR8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TLR8: PPH01801A
        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR8 (see all 4): PAHS-018A PAHS-025A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TLR8 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    TLR81   -- toll-like receptor 8 99.39(n)
    99.62(a)
    473522  XM_528893.2  XP_528893.2 
    cow
    (Bos taurus)
    TLR81   -- toll-like receptor 8 80.51(n)
    74.58(a)
    532262  NM_001033937.1  NP_001029109.1 
    mouse
    (Mus musculus)
    Tlr81 , 5 X (78.29 cM)5
    toll-like receptor 81, 5 76.76(n)1
    71.84(a)1
    1707441  NM_133212.21  NP_573475.21 
     AA6813385  AY0358905  (see all 6)
    zebrafish
    (Danio rerio)
    tlr8a1   -- toll-like receptor 8a 51.57(n)
    44.98(a)
    403137  XM_001920559.1  XP_001920594.1 
    About this table        Species with no ortholog for TLR8

    ENSEMBL Gene Tree for TLR8 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TLR8 gene
    ENSG000001733662  CD1802  LRRC322  TLR72  TLR32  TLR92  LRRC332  TLR42  

    TLR8 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/141 NCBI SNPs in TLR8 are shown (see all 141)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10131501,2
    C,F,A,H,12932441(+) TGGAAA/GATCCT 1 -- int114Minor allele frequency- N:0.00NS EA NA EU WA 736
    rs10131511,2
    C,F,A,H,12932531(+) cagaaT/Ctctct 1 -- int112Minor allele frequency- C:0.43NA EU MN NS EA WA 693
    rs15487311,2
    C,F,A,12927947(+) gtctgT/Caaagc 1 -- int122Minor allele frequency- C:0.67EA NA EU NS MN 1389
    rs21091341,2
    C,F,O,A,H,12927186(+) CCAGGA/TTCCAT 1 -- int122Minor allele frequency- T:0.04NA EA EU NS WA 1198
    rs21091351,2
    C,H,12939928(+) TGGGAC/TCCGGG 4 D syn1 ref1 ese313Minor allele frequency- T:0.00NA EA NS WA 680
    rs21593771,2
    C,F,A,12937513(+) ACAGAC/TGGGGC 4 D ref1 syn1 ese315Minor allele frequency- N:0.00NA EA EU NS 981
    rs22866261,2
    H12928764(+) GCGAAT/CGAGTT 1 -- int14Minor allele frequency- C:0.00NS EA 420
    rs24079921,2
    C,F,O,A,H,12939112(+) AGGCTC/GAAGCA 4 L syn1 ref1 ese317Minor allele frequency- N:0.00NA EU NS EA WA 917
    rs26254161,2
    H12941155(-) AAGCTA/GTCCAT 2 -- ut314Minor allele frequency- G:0.00NS EA 418
    rs37474141,2
    C,F,A,H,12939412(+) ACAATA/CAACAA 4 I syn1 ref114Minor allele frequency- C:0.47NA EU NS EA WA 659
    About this table

    HapMap Linkage Disequilibrium images for TLR8 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TLR8: --

    QIAGEN SeqTarget long-range PCR primers for resequencing TLR8 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TLR8 for disorders           About GeneDecksing

    OMIM: 300366

    6 Novoseek disease relationships for TLR8 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 46 5 14530316 (1), 19644151 (1), 19164127 (1), 17964520 (1)
    inflammation 20.7 1 14530316 (1)
    influenza 1.34 1 16959331 (1)
    necrosis 0 2 19527497 (1), 17548497 (1)
    tumors 0 5 20237413 (3), 19527497 (1), 17548497 (1)
    cancer 0 4 18176600 (2), 19848448 (1), 17476348 (1)
    About this table

    Locus Specific Mutation Databases (LSDB): TLR8
    Human Gene Mutation Database (HGMD): TLR8
    Human Genome Epidemiology (HuGE) Navigator: TLR8 (21 documents)

    Export disorders and mutations for TLR8 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/159 PubMed articles for TLR8 gene, integrated from 7 sources (see all 159):
    (articles sorted by number of sources associating them with TLR8)
    1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 7 Du X.... Beutler B. (2000)
    2. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2 Nakajima T....Kimura A. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. (PubMed id 11022120)1, 2 Chuang T.-H. and Ulevitch R.J. (2000)
    6. The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists. (PubMed id 17868034)1, 7 Rajagopal R....Wightman P.D. (2008)
    7. TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation. (PubMed id 19164127)1, 7 LarangAc A....Kerdine-RAPmer S. (2009)
    8. A five-amino-acid motif in the undefined region of th e TLR8 ectodomain is required for species-specific ligand recognition. (PubMed id 20004021)1, 7 Liu J....Chuang T.H. (2010)
    9. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders. (PubMed id 18682521)1, 7 Moller-Larsen S....Borglum A.D. (2008)
    10. Triggering of TLR7 and TLR8 expressed by human lung c ancer cells induces cell survival and chemoresistance. (PubMed id 20237413)1, 7 Cherfils-Vicini J....Cremer I. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51311 HGNC: 15632 AceView: TLR8 Ensembl:ENSG00000101916 euGenes: HUgn51311
    ECgene: TLR8 Kegg: 51311 H-InvDB: TLR8

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