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TTPA Gene

protein-coding   GIFtS: 52

GC08M059459
tocopherol (alpha) transfer protein
(Previous name: ataxia (Friedreich-like) with vitamin E deficiency )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AVED)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
tocopherol (alpha) transfer protein1 2     alpha-tocopherol transfer protein2
AVED2 5     alphaTTP2
TTP12 5     tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E
deficiency)2
ataxia (Friedreich-like) with vitamin E deficiency1     Alpha-TTP3
ATTP2     TPP13
alpha-TTP2     

External Ids:    HGNC: 124041   Entrez Gene: 72742   Ensembl: ENSG000001375617   UniProtKB: P496383   

Export aliases for TTPA gene to outside databases

Previous GC identifers: GC08M063337 GC08M063913 GC08M063695 GC08M064022 GC08M064134


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TTPA:
This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and
affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E
between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins.
Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis
pigmentosa. (provided by RefSeq)

UniProtKB/Swiss-Prot: TTPA_HUMAN, P49638
Function: Binds alpha-tocopherol and enhances its transfer between separate membranes

Gene Wiki entry for TTPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTPA gene promoter:
         PPAR-gamma1   PPAR-gamma2   FOXD1   MEF-2A   FAC1   RSRFC4   Cart-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TTPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TTPA 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.3   Ensembl cytogenetic band:  8q12.3   HGNC cytogenetic band: 8q12.3

TTPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTPA gene location

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M059459:  view genomic region     (about GC identifiers)

Start:
59,459,917 bp from pter
End:
59,486,481 bp from pter
Size:
26,565 bases
Orientation:
minus strand

1 alternative location:
Chr8- 63,961,112-63,998,612     
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TTPA_HUMAN, P49638 (See protein sequence)
Recommended Name: Alpha-tocopherol transfer protein  
Size: 278 amino acids; 31750 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1OIP (3D)    1OIZ (3D)    1R5L (3D)    
Secondary accessions: Q71V64

Explore the universe of human proteins at neXtProt for TTPA: NX_P49638 

REFSEQ proteins: NP_000361.1  

ENSEMBL proteins: 
ENSP00000260116 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for TTPA 
Novus Biologicals Proteins for TTPA
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005737 cytoplasm IEA--
GO:0005770 late endosome IEA--
GO:0005829 cytosol IEA--
About this table

TTPA for ontologies           About GeneDecksing



Antibodies for TTPA: 
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Assays for TTPA: 
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Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TTPA for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001071 CRAL-bd_toc_tran
 IPR001251 CRAL-bd_TRIO_C
 IPR011074 Sec14p-like_N
 IPR008273 CRAL-bd_TRIO_N

Graphical View of Domain Structure for InterPro Entry P49638

ProtoNet protein and cluster: P49638

3 Blocks protein families:
IPB001071 Cellular retinaldehyde-binding protein signature
IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
IPB008273 Cellular retinaldehyde-binding/triple function


UniProtKB/Swiss-Prot: TTPA_HUMAN, P49638
Similarity: Contains 1 CRAL-TRIO domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TTPA_HUMAN, P49638
Function: Binds alpha-tocopherol and enhances its transfer between separate membranes

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for TTPA
Sigma-Aldrich shRNA for TTPA
OriGene 29mer shRNA kits in GFP-retroviral vector: TTPA
OriGene shRNA RFP: TTPA
OriGene basic RS shRNA: TTPA
OriGene siRNA: TTPA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TTPA 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TTPA 
Search SABiosciences for Assays for microRNAs that regulate TTPA

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: TTPA
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TTPA
OriGene untagged cDNA clones in CMV expression vector: TTPA
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for TTPA 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for TTPA 

Genatlas biochemistry entry for TTPA:
alpha-tocopherol transfer protein

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005215 transporter activity IEA--
GO:0008431 vitamin E binding IEA--
GO:0019842 vitamin binding ----
About this table

TTPA for ontologies           About GeneDecksing

Animal Models: 8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ttpa):

behavior/neurologicalcardiovascular systemembryogenesishomeostasis/metabolismmuscle
nervous systemreproductive systemvision/eye

TTPA for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for TTPA 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTPA

5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

GO IDQualified GO termEvidencePubMed IDs
GO:0001890 placenta development ----
GO:0001892 embryonic placenta development IEA--
GO:0006629 lipid metabolic process TAS7887897
GO:0006810 transport TAS7887897
GO:0007584 response to nutrient IEA--
About this table

TTPA for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

TTPA for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTPA
10/13 Novoseek chemical compound relationships for TTPA gene (see all 13)
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
alpha tocopherol 92.5 321 20368946 (5), 14531858 (5), 20187127 (4), 9356467 (4) (see all 99)
tocopherol 91.1 56 18458085 (3), 15318806 (2), 15753136 (2), 15753158 (2) (see all 28)
vitamin-e 88.6 139 10082886 (3), 10727494 (3), 20368946 (3), 18458085 (3) (see all 57)
delta-tocopherol 75.3 1 16491383 (1)
alpha-tocopherol quinone 64.6 3 9801162 (2)
lipid 31.2 6 19458973 (1), 12767229 (1), 18458085 (1), 16430203 (1)
phosphatidylinositol 25.7 3 11226224 (1), 12767229 (1)
cholesterol 13.9 3 9356467 (1), 20387845 (1), 10540874 (1)
atp 0 1 17252538 (1)
oxygen 0 3 10867030 (1), 18511174 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for TTPA
Sigma-Aldrich shRNA for TTPA
OriGene 29mer shRNA kits in GFP-retroviral vector: TTPA
OriGene shRNA RFP: TTPA
OriGene basic RS shRNA: TTPA
OriGene siRNA: TTPA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TTPA 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TTPA 
Search SABiosciences for Assays for microRNAs that regulate TTPA
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: TTPA
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TTPA
OriGene untagged cDNA clones in CMV expression vector: TTPA
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for TTPA 
Primers: OriGene genome-wide validated SYBR primer pairs: TTPA
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TTPA: PPH09797A

REFSEQ mRNAs for TTPA gene: 

NM_000370.3  

Additional cDNA sequence: 

BC041784.1 BC058000.1 D49488.1 U21938.1 

2 DOTS entries:

DT.101976708  DT.204951 

18 AceView cDNA sequences:

BX283648 BC058000 BM463341 D49488 NM_000370 BC041784 AW043604 AL119672 
BG614543 BX101071 BG427807 H68464 U21938 BE971379 N56849 H68830 
AA703331 BG400921 

highest scoring ESTs for TTPA:

D49488 BC041784 BC058000 BG427807 U21938 AL119672 AU100411 AW043604 BG400921 BG614543 

Unigene Cluster for TTPA:

Tocopherol (alpha) transfer protein
Hs.69049  [show with all ESTs]
Unigene Representative Sequence: NM_000370


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000260116(uc003xux.1) ENST00000521138

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TTPA expression in normal and diseased human tissues

1  / 2  / 3

4 probe-sets matching TTPA gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
34617_at2, 3 U95-A 1 1.00 1.00 0.89 0.90 D49488 1.00 1.00 1.00 1
68907_at2, 3 U95-E 1 0.69 1.00 0.91 1.32 AW043604 0.60 1.00 0.82 1
210614_at2, 3 U133-A 1 0.91 1.00 -- -- U21938 0.80 1.00 0.91 1
210614_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table

TTPA for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
TTPA gene expression
TTPA gene electronic northern expression
TTPA gene sage expression
About these images

CGAP SAGE TAG: TGTTCACAAA

SOURCE GeneReport for Unigene cluster: Hs.69049

Expression variation in blood from EXPOLDB for TTPA

Primers: OriGene genome-wide validated SYBR primer pairs: TTPA
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TTPA: PPH09797A
    SABiosciences Custom PCR Arrays for TTPA 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TTPA gene from 5/8 species (see all 8)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TTPA1   -- tocopherol (alpha) transfer protein 91(n)
93.84(a)
403627  XM_535088.2  XP_535088.2 
chimpanzee
(Pan troglodytes)
TTPA1   -- tocopherol (alpha) transfer protein 99.16(n)
99.28(a)
472778  XM_528150.2  XP_528150.2 
cow
(Bos taurus)
TTPA1   -- tocopherol (alpha) transfer protein 88.82(n)
91.77(a)
286813  XM_587081.3  XP_587081.3 
rat
(Rattus norvegicus)
Ttpa1   -- tocopherol (alpha) transfer protein 85.73(n)
88.85(a)
25571  NM_013048.2  NP_037180.1 
mouse
(Mus musculus)
Ttpa1 , 5 4 (7.76 cM)5
tocopherol (alpha) transfer protein1, 5 86.57(n)1
89.21(a)1
505001  NM_015767.21  NP_056582.11 
 AA7895675  AF2184165  (see all 14)
About this table        Species with no ortholog for TTPA

ENSEMBL Gene Tree for TTPA (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for TTPA gene
RLBP12  TTPAL2  CLVS22  CLVS12  

TTPA for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/256 NCBI SNPs in TTPA are shown (see all 256)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 8 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs20452241,2
C,F63973988(+) ATCTGA/CAATAG 1 -- int15Minor allele frequency- C:0.01MN 408
rs23526581,2
--63977799(+) gggctC/Ggaatt 1 -- int10--------
rs42898041,2
C63993047(+) aggccA/Gaggca 1 -- int10--------
rs44467291,2
C,F,A,H,63983203(+) CTACAC/TGAGGC 1 -- int111Minor allele frequency- T:0.11NS EA NA WA 500
rs44815861,2
--63993291(+) AAAAAA/TAAATA 1 -- int1 trp30--------
rs45015701,2
C,F,A,H,63976754(+) AATATG/ATTTTA 1 -- int110Minor allele frequency- A:0.37MN NA EA WA 554
rs45873281,2
C,F,A,H,63972718(+) AGTTAT/CGTTAT 1 -- ut31 ese37Minor allele frequency- C:0.39NA EA WA 306
rs46060521,2
C,F,A,H,63976677(+) AGGTAT/CGAGGA 1 -- int118Minor allele frequency- C:0.41NS EA NA MN WA 1210
rs47376261,2
C,F,63974218(+) ATAAAA/GTTTAT 1 -- int11Minor allele frequency- G:0.31EA 88
rs47390461,2
C,F,A,63979488(+) CCAGGT/CGCAgg 1 -- int15Minor allele frequency- C:0.22NS EA 506
About this table

HapMap Linkage Disequilibrium images for TTPA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TTPA: --

QIAGEN SeqTarget long-range PCR primers for resequencing TTPA 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TTPA for disorders           About GeneDecksing

OMIM: 600415   disorders: 277460  

UniProtKB/Swiss-Prot: TTPA_HUMAN, P49638

  • Defects in TTPA are the cause of ataxia with isolated vitamin E deficiency (AVED) [MIM:277460]. AVED is an
  • autosomal recessive disease characterized by spinocerebellar degeneration. It causes ataxia and peripheral neuropathy
    that resembles Friedreich ataxia. AVED patients have markedly reduced plasma levels of vitamin E

    10/15 Novoseek disease relationships for TTPA gene (see all 15)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin e deficiency 96.6 56 10082886 (3), 15300460 (2), 18458655 (2), 20368946 (2) (see all 34)
    friedreich ataxia 78.3 8 10996881 (1), 9463307 (1), 12470185 (1), 17112370 (1) (see all 5)
    abetalipoproteinemia 71.7 2 10082886 (1)
    spinocerebellar ataxias 57.6 2 10082886 (1), 16491383 (1)
    retinitis pigmentosa 56.3 10 9189046 (2), 11754917 (2), 10727494 (2), 8965888 (1) (see all 5)
    protein deficiency 53.6 2 9645052 (1), 9931538 (1)
    neurodegenerative diseases 44.2 9 12470185 (1), 15300460 (1), 17628170 (1), 10082886 (1) (see all 5)
    apraxias 31.9 2 17112370 (1)
    neurodegeneration 29.1 2 14642382 (1), 17628171 (1)
    neurological disorders 29.1 3 15753133 (1), 20368946 (1), 16819822 (1)
    About this table

    GeneTests: TTPA
    Ataxia with Vitamin E Deficiency

    Human Gene Mutation Database (HGMD): TTPA
    Human Genome Epidemiology (HuGE) Navigator: TTPA (53 documents)

    Export disorders and mutations for TTPA gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/120 PubMed articles for TTPA gene, integrated from 7 sources (see all 120):
    (articles sorted by number of sources associating them with TTPA)
    1. Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. (PubMed id 7887897)1, 2, 3, 7 Arita M.... Inoue K. (1995)
    2. Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. (PubMed id 7719340)1, 2, 3, 7 Ouahchi K.... Koenig M. (1995)
    3. Human alpha-tocopherol transfer protein: gene structure and mutations in familial vitamin E deficiency. (PubMed id 8602747)1, 2, 7 Hentati A.... Siddique T. (1996)
    4. Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer protein. (PubMed id 7566022)1, 2, 7 Gotoda T.... Yamada N. (1995)
    5. The molecular basis of vitamin E retention: structure of human alpha- tocopherol transfer protein. (PubMed id 12899840)1, 2, 7 Meier R.... Stocker A. (2003)
    6. Ataxia with isolated vitamin E deficiency: neurological phenotype, clinical follow-up and novel mutations in TTPA gene in Italian families. (PubMed id 15300460)1, 2, 7 Mariotti C.... Di Donato S. (2004)
    7. Ataxia with isolated vitamin E deficiency: heterogeneity of mutations and phenotypic variability in a large number of families. (PubMed id 9463307)1, 2, 7 Cavalier L.... Koenig M. (1998)
    8. Molecular determinants of heritable vitamin E deficiency. (PubMed id 15065857)1, 2, 7 Morley S.... Manor D. (2004)
    9. Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency. (PubMed id 14657365)1, 2, 7 Min K.C.... Hendrickson W.A. (2003)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7274 HGNC: 12404 AceView: TTPA Ensembl:ENSG00000137561 euGenes: HUgn7274
    ECgene: TTPA H-InvDB: TTPA

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TTPA

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TTPA gene:
    Search GeneIP for patents involving TTPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for TTPA Browse antibodies at Sigma-Aldrich
     Super-pooled esiRNAs for TTPA Browse proteins at Sigma-Aldrich
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     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TTPA
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     GenScript Custom Purified and Recombinant Proteins Services for TTPA GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TTPA
     GenScript Custom Assay Services for TTPA GenScript Custom Superior Antibodies Services for TTPA
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     Browse antibodies at Epitomics
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     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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