Aliases &
Descriptions
for XAGE1D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| X antigen family, member 1D1 2 | | cancer/testis antigen family 12, member 1d2 | | Protein XAGE-12 3 | | XAGE1A2 | | Cancer/testis antigen 12.12 3 | | CT12.1D2 | | CT12.12 3 | | cancer/testis associated protein2 | | GAGED23 5 | | XAGE1C2 | | XAGE13 5 | | XAGE1E2 | | CT12.1d1 | | XAGE1B2 | | G antigen family D member 22 | | OTTHUMP000000233152 | | OTTHUMP000002183072 | | CTP92 |
Export aliases for XAGE1D gene to outside databasesPrevious GC identifer: GC0XU900701 |
Summaries
for XAGE1D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XAGE1D:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in avariety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma,alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signaland shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequencesimilarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene,in addition to alternative transcription start sites, results in multiple transcript variants. (provided by RefSeq)
Gene Wiki entry for XAGE1D |
Genomic Views
for XAGE1D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for XAGE1D
Other transcription factors
Search SABiosciences Chromatin IP Primers for XAGE1D
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22XAGE1D Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM052545: view genomic region
(about GC identifiers)
Start:
|
52,528,159 bp from pter |
End:
|
52,533,303 bp from pter |
Size:
|
5,145 bases |
Orientation:
|
minus strand |
0 alternative location:
RefSeq DNA sequence:- NC_000023.10 NT_011630.14
|
Proteins
for XAGE1D gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64 (See
protein sequence)Recommended Name: G antigen family D member 2 Size: 160 amino acids; 17751 Da
Sequence caution: Sequence=AAG01401.1; Type=Erroneous initiation;
Secondary accessions: A6NJ94 Q5JPN8 Q5JPP0 Q5JPP3 Q8WWG5 Q8WWG6 Q969J6Alternative splicing: 3 isoforms: Q9HD64-3 Q9HD64-2 Q9HD64-4 Explore the universe of human proteins at neXtProt for XAGE1D: NX_Q9HD64
REFSEQ proteins (2 alternative transcripts):
NP_065144.2 NP_597673.1
ENSEMBL proteins: ENSP00000389220 ENSP00000364097 ENSP00000379755 ENSP00000364728
Human Recombinant Proteins
Antibodies for XAGE1D:
Assays for XAGE1D: |
Protein
Domains/
Families
for XAGE1D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9HD64 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64Similarity: Belongs to the GAGE family |
Gene Function
for XAGE1D gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
|
Pathways & Interactions
for XAGE1D gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for XAGE1D
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XAGE1D
|
Drugs & Compounds
for XAGE1D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for XAGE1D
|
Transcripts
for XAGE1D gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for XAGE1D gene (2 alternative transcripts): NM_020411.2 NM_133430.2 Additional cDNA sequence: AJ290447.1 AJ318879.1 13 DOTS entries: DT.100021393 DT.411576 DT.91677790 DT.91677782 DT.100736412 DT.97825377 DT.121280905 DT.121280912 DT.411577 DT.99982060 DT.121290883 DT.121290887 DT.91677799 24/45 AceView cDNA sequences (see all 45): NM_133430 AA620697 BE881023 NM_020411 AF251237 BC009538 AJ318878 NM_133431 AA948244 BX101350 AJ318879 AW386187 AI631681 AJ290447 AI954712 BU564534 BU182421 AA758618 BE875341 BT007099 AA483082 BI460303 AA483341 BG216048 Unigene Clusters for XAGE1D: X antigen family, member 1D Hs.112208 [show with all ESTs], Hs.584511 Unigene Representative Sequences: BG191783, NM_133430
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000438079 ENST00000375572(uc004dqq.2) ENST00000478767 ENST00000374959
ENST00000396497(uc004dqr.2 uc004dqs.2) ENST00000375578
|
Expression
for XAGE1D gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| XAGE1D expression in normal and diseased human tissues
1 / 2 3 probe-sets matching XAGE1D gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 56998_at2
|
U95-B |
5 |
0.75 |
0.20 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
| 220057_at2
|
U133-A |
5 |
0.64 |
0.20 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 220057_at2
|
U133Plus2 |
5 |
0.64 |
0.20 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
XAGE1D for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAAGGTGATC
SOURCE GeneReport for Unigene clusters: Hs.112208 Hs.584511
UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers:highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma,small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing'ssarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample
SABiosciences Custom PCR Arrays for XAGE1D
|
Orthologs
for XAGE1D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for XAGE1D gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
XAGE1A1 |
-- |
X antigen family, member 1A |
98.75(n)
96.87(a) |
741118 XM_001143525.1 XP_001143525.1 |
About this table Species with no ortholog for XAGE1D
ENSEMBL Gene Tree for XAGE1D (if available) |
Paralogs
for XAGE1D gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for XAGE1D gene
- XAGE1E1 2 XAGE1B2 XAGE1A2 XAGE1C2
XAGE1D for paralogs About GeneDecksing
|
Genomic Variants
for XAGE1D gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for XAGE1D
14 CNVs: 83524 73977 83525 83526 96688 73976 67978 96689 83523 83522 96685 96687 96684 96686
1 Inversion: 37381 |
Disorders & Mutations
for XAGE1D gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XAGE1D for disorders About GeneDecksing
OMIM: 300289
10/11  Novoseek disease relationships for XAGE1D gene (see all 11)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenocarcinoma lung |
68.8 |
4 |
11753648 (3) |
| ewings sarcoma |
68.7 |
3 |
11753648 (1), 11774264 (1), 12479262 (1) |
| testicular cancer |
68.5 |
3 |
11753648 (1), 12479262 (1), 17335148 (1) |
| small cell lung cancer |
49.6 |
1 |
12479262 (1) |
| cancer lung |
45.6 |
2 |
12479262 (1), 17335148 (1) |
| melanoma |
26.5 |
2 |
11774264 (1), 12479262 (1) |
| adenocarcinoma |
24.7 |
1 |
12479262 (1) |
| prostate cancer |
24 |
7 |
15905609 (4), 12479262 (1) |
| cancer |
22.1 |
7 |
12479262 (2), 11774264 (1), 16061866 (1), 15905609 (1) |
| metastasis |
8.39 |
4 |
11774264 (2), 15905609 (1) |
About this table
Export disorders and mutations for XAGE1D gene to outside databases
|
Medical News
for XAGE1D gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for XAGE1D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for XAGE1D gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with XAGE1D)- Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (PubMed id 12479262)1, 2, 7 Egland K.A.... Pastan I. (2002)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (2002)
- XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (PubMed id 10987281)1, 2 Liu X.F.... Pastan I. (2000)
- XAGE-1 expression in non-small cell lung cancer and antibody response in patients. (PubMed id 16061866)1, 7 Nakagawa K....Nakayama E. (2005)
- XAGE-1 mRNA expression in prostate cancer and antibody response in patients. (PubMed id 15905609)1, 7 Koizumi F....Nakayama E. (2005)
- Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis. (PubMed id 11774264)1, 7 Zendman A.J....van Muijen G.N. (2002)
- Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PubMed id 17335148)1, 7 Sato S....Nakayama E. (2007)
- [Association of XAGE-1 gene expression with clinical characteristics of lung cancer]. (PubMed id 20704819)1 Lai Q....Sun Y. (2010 Aug 20)
|
External Searches for XAGE1D gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing XAGE1D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing XAGE1D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XAGE1D gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for XAGE1D gene:
Search GeneIP for patents involving XAGE1D
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XAGE1D gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for XAGE1D |
| |  |  |  |  | | | | |
 | | |
|
|
