Aliases &
Descriptions
for ZBED1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger, BED-type containing 11 2 | | Putative Ac-like transposable element2 3 | | KIAA07851 2 3 5 | | dREF homolog2 3 | | TRAMP1 2 3 5 | | OTTHUMP000002148632 | | DREF1 2 3 | | putative Ac-like transposon2 | | ALTE2 3 5 | | zinc finger BED domain-containing protein 12 | | Ac-like transposable element1 2 | | BED-type zinc finger domain-containing protein 12 | | hDREF1 2 | | DNA replication-related element binding factor2 |
Export aliases for ZBED1 gene to outside databasesPrevious GC identifers: GC0XM001999 GC0YM002320 GC0XM002320 GC0XM002148 |
Summaries
for ZBED1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZBED1:
This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a genewith similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies showthat this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elementsfound in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have arole in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5'untranslated region have been found for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006Function: Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related tocell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weaklysimilar to Ac transposable elements, but does not code for any transposase activity
Gene Wiki entry for ZBED1 |
Genomic Views
for ZBED1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZBED1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBED1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.33;Yp11 Ensembl cytogenetic band: Xp22.33 HGNC cytogenetic band: Xp22.33 and Yp11ZBED1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM000346: view genomic region
(about GC identifiers)
Start:
|
346,909 bp from pter |
End:
|
361,036 bp from pter |
Size:
|
14,128 bases |
Orientation:
|
minus strand |
2 alternative locations:
| ChrX- 2,404,477-2,419,008 | ChrY- 2,354,455-2,369,008 |
|
Proteins
for ZBED1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006 (See
protein sequence)Recommended Name: Zinc finger BED domain-containing protein 1 Size: 694 amino acids; 78156 Da
Subunit: Homodimer (Potential)
Subcellular location: Nucleus. Note=In granular structures
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Ychromosomes
Sequence caution: Sequence=BAA34505.2; Type=Erroneous initiation;
PDB structures from  and Proteopedia  :2CT5 (3D)
Secondary accessions: Q96BY4Explore the universe of human proteins at neXtProt for ZBED1: NX_O96006
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001164606.1 NP_001164607.1 NP_004720.1
ENSEMBL proteins: ENSP00000419148 ENSP00000370620 ENSP00000370616
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ZBED1 for ontologies About GeneDecksing
Antibodies for ZBED1:
Assays for ZBED1: |
Protein
Domains/
Families
for ZBED1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBED1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O96006ProtoNet protein and cluster: O96006 1 Blocks protein family: IPB008906 HAT dimerisation
UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006Similarity: Contains 1 BED-type zinc finger |
Gene Function
for ZBED1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006Function: Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related tocell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weaklysimilar to Ac transposable elements, but does not code for any transposase activityInduction: Expression is linked to the cell cycle: low in serum-starved fibroblasts, increasing during the G1/S phase,highest during the S/G2 phase and then decreasing again
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
ZBED1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBED1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZBED1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBED1
5/11 Interacting proteins for ZBED1 (O960061, 2) via UniProtKB, MINT, and/or STRING (see all 11)About this table
|
Drugs & Compounds
for ZBED1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZBED1
|
Transcripts
for ZBED1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZBED1 gene (3 alternative transcripts): NM_001171135.1 NM_001171136.1 NM_004729.3 24/192 AceView cDNA sequences (see all 192): AI752969 BE899456 BF940271 M78108 AW196831 CR597100 BE269286 BQ674932 CR613724 AV655439 BM837900 AI682592 BU509734 AL705875 BM549506 AI494595 AA302814 AA496808 BG747354 BF970891 AI560640 BV199713 AI953192 AI272762
 highest scoring ESTs for ZBED1:AA216160 AA496808 BE296471 BE741290 BF837834 BG386894 BI114791 BM788079 BM907310 BQ062092
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461691 ENST00000381222(uc004cqh.1 uc004cqg.2) ENST00000381218
|
Expression
for ZBED1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZBED1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching ZBED1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39168_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
0.98 |
0.94 |
AB018328 |
0.80 |
0.70 |
0.75 |
1 |
| 44978_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.98 |
1.06 |
AI979194 |
0.40 |
0.67 |
0.55 |
1 |
| 203043_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
NM_004729 |
0.40 |
0.67 |
0.55 |
1 |
| 1554821_a_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 203043_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZBED1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
Expression variation in blood from EXPOLDB for ZBED1 UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006Tissue specificity: Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen andplacenta
SABiosciences Custom PCR Arrays for ZBED1
|
Orthologs
for ZBED1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZBED1 gene from 5/6 species (see all 6)
About this table Species with no ortholog for ZBED1
ENSEMBL Gene Tree for ZBED1 (if available) |
Paralogs
for ZBED1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZBED1 gene
- ZBED42
ZBED1 for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for ZBED1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZBED1
3 CNVs: 31578 4142 31543 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZBED1 |
|
Disorders & Mutations
for ZBED1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBED1 for disorders About GeneDecksing
OMIM: 300178
Locus Specific Mutation Databases (LSDB): ZBED1
Export disorders and mutations for ZBED1 gene to outside databases
|
Medical News
for ZBED1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZBED1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/49 PubMed articles for ZBED1 gene, integrated from 7 sources (see all 49):
(articles sorted by number of sources associating them with ZBED1)- A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases. (PubMed id 9887332)1, 2, 3, 7 Esposito T.... Forabosco A. (1999)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
- Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene. (PubMed id 12663651)1, 2, 7 Ohshima N.... Hirose F. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hDREF regulates cell proliferation and expression of ribosomal protein genes. (PubMed id 17220279)1, 7 Yamashita D....Hirose F. (2007)
- Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)
- Human DNA replication-related element binding factor (hDREF) self- association via hATC domain is necessary for its nuclear accumulation and DNA binding. (PubMed id 17209048)1 Yamashita D....Hirose F. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
|
External Searches for ZBED1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBED1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBED1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZBED1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZBED1 gene:
Search GeneIP for patents involving ZBED1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBED1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for ZBED1 |
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 | | | ELISAs and CLIAs for ZBED1 |
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