Aliases &
Descriptions
for ZNF10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| zinc finger protein 101 2 | | KOX11 2 3 5 | | zinc finger protein 10 (KOX 1)1 2 | | Zinc finger protein KOX12 3 |
Export aliases for ZNF10 gene to outside databasesPrevious GC identifers: GC12P131228 GC12P133310 GC12P131897 GC12P131392 GC12P132317 |
Summaries
for ZNF10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZNF10:
The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptionalrepressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptionalrepression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serveas a mediator for the repression activity of this protein. (provided by RefSeq)
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506Function: May be involved in transcriptional regulation
Gene Wiki entry for ZNF10 |
Genomic Views
for ZNF10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF10 gene promoter:
CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ZNF10  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33ZNF10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P133708: view genomic region
(about GC identifiers)
Start:
|
133,707,214 bp from pter |
End:
|
133,781,730 bp from pter |
Size:
|
74,517 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 130,486,365-130,514,967 |
RefSeq DNA sequence:- NC_000012.11 NT_024477.14
|
Proteins
for ZNF10 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506 (See
protein sequence)Recommended Name: Zinc finger protein 10 Size: 573 amino acids; 66455 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RBS1 Q8TC91Explore the universe of human proteins at neXtProt for ZNF10: NX_P21506
REFSEQ proteins: NP_056209.2
ENSEMBL proteins: ENSP00000384893 ENSP00000393814 ENSP00000409295 ENSP00000248211 ENSP00000228289
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
ZNF10 for ontologies About GeneDecksing
Antibodies for ZNF10:
Assays for ZNF10: |
Protein
Domains/
Families
for ZNF10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21506ProtoNet protein and cluster: P21506 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Gene Function
for ZNF10 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: ZNF10_HUMAN, P21506Function: May be involved in transcriptional regulation
Genatlas biochemistry entry for ZNF10:zinc finger protein 10 (KOX1) (C2H2 type,Kruppel-like)5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
ZNF10 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF10 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for ZNF10
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF10
1 Interacting protein for ZNF10 (ENSP000002482113 P215061) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
About this table
ZNF10 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
ZNF10 for compounds About GeneDecksing
 Browse Tocris compounds for ZNF10
1  Novoseek chemical compound relationship for ZNF10 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| zinc |
55 |
4 |
10320774 (1), 9278146 (1), 8723389 (1) |
About this table
|
Transcripts
for ZNF10 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for ZNF10 gene: NM_015394.4 Additional cDNA sequence: AK314784.1 AL110188.1 BC024182.2 X52332.1 10 DOTS entries: DT.310962 DT.40120522 DT.121213897 DT.121214075 DT.100744886 DT.121213981 DT.75116105 DT.121214143 DT.75124016 DT.100776858 24/72 AceView cDNA sequences (see all 72): AI972895 AA649047 BC024182 CB155180 AL110188 AI373657 BX116826 AI305171 BU683824 AI038094 AA374600 BM711074 BQ954641 BP377793 AA668926 AI382864 AI078585 BM666170 BM721456 NM_015394 BQ721103 X52332 BP367323 CA406372
 highest scoring ESTs for ZNF10:AI972895 D61167 X52332 AA281993 AA374600 AA649047 AA668926 AI038094 AI078585 AI280070 Unigene Cluster for ZNF10: Zinc finger protein 10 Hs.507355 [show with all ESTs]Unigene Representative Sequence: BC024182
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF10 (see all 9)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for ZNF10
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402932 ENST00000426665 ENST00000416488 ENST00000248211(uc009zzb.2 uc001ulq.2)
ENST00000228289(uc010tbv.1 uc010tbw.1 uc010tbx.1 uc010tby.1 uc010tbz.1 uc010tca.1 uc010tcb.1 uc010tcc.1 uc010tcd.1 uc010tce.1 uc010tcf.1 uc010tcg.1 uc010tch.1)
|
Expression
for ZNF10 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| ZNF10 expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching ZNF10 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 31707_at2, 3
|
U95-A |
1 |
0.50 |
1.00 |
0.89 |
0.63 |
X52332 |
1.00 |
1.00 |
1.00 |
1 |
| 69929_at2, 3
|
U95-E |
1 |
0.50 |
1.00 |
0.96 |
0.76 |
D61167 |
1.00 |
1.00 |
1.00 |
1 |
| 62997_at2, 3
|
U95-C |
1 |
0.44 |
1.00 |
0.69 |
1.64 |
AI972895 |
1.00 |
1.00 |
1.00 |
1 |
| 216350_s_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
X52332 |
1.00 |
1.00 |
1.00 |
1 |
| 229848_at2, 3
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
W72653 |
0.60 |
1.00 |
0.82 |
1 |
| 235366_at2, 3
|
U133-B |
1 |
0.27 |
1.00 |
-- |
-- |
BF970692 |
0.80 |
1.00 |
0.91 |
1 |
| 216350_s_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 229848_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 235366_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
ZNF10 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTCCTGCTG
SOURCE GeneReport for Unigene cluster: Hs.507355
Expression variation in blood from EXPOLDB for ZNF10 SABiosciences Custom PCR Arrays for ZNF10
|
Orthologs
for ZNF10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for ZNF10 (if available) |
Paralogs
for ZNF10 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZNF10 gene
- LOC1002874292 ZNF6052 ZNF842 ZNF6302 ZNF5682 ENSG000002296312 ENSG000002365752 ZNF4322
- ZNF6142 ZNF262 ZNF6132 ZNF6492 ZNF3002 ZNF5692
ZNF10 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF10 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for ZNF10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for ZNF10
13 CNVs: 66385 86695 29933 66384 76244 76240 37673 30627 76243 53396 3002 29934 66386 | | QIAGEN SeqTarget long-range PCR primers for resequencing ZNF10 |
|
Disorders & Mutations
for ZNF10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF10 for disorders About GeneDecksing
OMIM: 194538
Export disorders and mutations for ZNF10 gene to outside databases
|
Medical News
for ZNF10 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZNF10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for ZNF10 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with ZNF10)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PubMed id 7865130)1, 3 Abrink M.... Hellman L. (1995)
- Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19 . (PubMed id 8262519)1, 3 Rousseau-Merck M.F....Berger R. (1993)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor. (PubMed id 9278146)1, 7 Moosmann P....Schaffner W. (1997)
- Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. (PubMed id 10748030)1, 7 Peng H....Rauscher F.J. (2000)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation. (PubMed id 11405226)1 Lorenz P....Thiesen H.J. (2001)
|
External Searches for ZNF10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF10 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ZNF10 gene:
Search GeneIP for patents involving ZNF10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF10 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for ZNF10 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for ZNF10 |
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