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ZNF430 Gene

protein-coding   GIFtS: 41

GC19P020694
zinc finger protein 430
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 4301 2
FLJ136591 2
MGC1332322
DKFZp762K0122

External Ids:    HGNC: 208081   Entrez Gene: 802642   Ensembl: ENSG000001186207   UniProtKB: Q9H8G13   

Export aliases for ZNF430 gene to outside databases

Previous GC identifers: GC19P020979 GC19P020995 GC19P021203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN430_HUMAN, Q9H8G1
Function: May be involved in transcriptional regulation


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF430 gene promoter:
         CP1A   NF-Y   NF-YA   USF1   Pax-5   RFX1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF430

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF430 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF430 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P020694:  view genomic region     (about GC identifiers)

Start:
20,694,593 bp from pter
End:
20,733,779 bp from pter
Size:
39,187 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 21,203,497-21,241,653     
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN430_HUMAN, Q9H8G1 (See protein sequence)
Recommended Name: Zinc finger protein 430  
Size: 570 amino acids; 66319 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAB14656.1; Type=Frameshift; Positions=293;
Secondary accessions: Q86V70

Explore the universe of human proteins at neXtProt for ZNF430: NX_Q9H8G1 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001166142.1  NP_079465.3  


    ENSEMBL proteins: 
    ENSP00000261560 


    Human Recombinant Proteins 
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    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    ZNF430 for ontologies           About GeneDecksing



    Antibodies for ZNF430: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF430 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H8G1

    ProtoNet protein and cluster: Q9H8G1

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN430_HUMAN, Q9H8G1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ZN430_HUMAN, Q9H8G1
    Function: May be involved in transcriptional regulation

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for ZNF430
    Sigma-Aldrich shRNA for ZNF430
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZNF430
    OriGene shRNA RFP (see all 2): ZNF430
    OriGene basic RS shRNA (see all 2): ZNF430
    OriGene siRNA (see all 2): ZNF430
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF430 
    miRNA:Sigma-Aldrich microRNA Mimics for ZNF430
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF430 
    Search SABiosciences for Assays for microRNAs that regulate ZNF430

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ZNF430
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZNF430
    OriGene untagged cDNA clones in CMV expression vector: ZNF430
    OriGene 3'-UTR clone: ZNF430 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNF430 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ZNF430 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    ZNF430 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ZNF430 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF430

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table

    ZNF430 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF430


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for ZNF430
    Sigma-Aldrich shRNA for ZNF430
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZNF430
    OriGene shRNA RFP (see all 2): ZNF430
    OriGene basic RS shRNA (see all 2): ZNF430
    OriGene siRNA (see all 2): ZNF430
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF430 
    miRNA: Sigma-Aldrich microRNA Mimics for ZNF430
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF430 
    Search SABiosciences for Assays for microRNAs that regulate ZNF430
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ZNF430
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZNF430
    OriGene untagged cDNA clones in CMV expression vector: ZNF430
    OriGene 3'-UTR Clone: ZNF430 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNF430 
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF430
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF430: PPH16726A

    REFSEQ mRNAs for ZNF430 gene (2 alternative transcripts): 

    NM_001172671.1  NM_025189.3  

    Additional cDNA sequence: 

    AK023721.1 AK127154.1 AK290475.1 AL832422.1 AY269787.1 BC111776.1 

    8 DOTS entries:

    DT.40290520  DT.433644  DT.121496377  DT.408247  DT.91643661  DT.101981534  DT.91857359  DT.95114454 

    24/26 AceView cDNA sequences (see all 26):

    BX504753 AI081603 BQ706964 AA314140 AU143734 AY269787 AU139909 BU193870 
    AL832422 AA375490 CD644291 NM_025189 BQ638610 AK023721 BQ636523 AA309966 
    BX471470 AW206930 AV707929 AI623759 AW963798 AW005593 CB963957 AU158222 

    highest scoring ESTs for ZNF430:

    AA309966 AK023721 AL832422 AU139909 AU143734 AV707929 AW963798 AY269787 BM904065 BQ636523 

    Unigene Cluster for ZNF430:

    Zinc finger protein 430
    Hs.466289  [show with all ESTs]
    Unigene Representative Sequence: NM_025189


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF430

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                                                
    SP2:                                                
    SP3:                    -     -     -               

    About this scheme

    ECgene alternative splicing isoforms for ZNF430
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000261560(uc002npj.2 uc002npk.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZNF430 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching ZNF430 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    73716_r_at2, 3 U95-E 1 0.62 1.00 1.00 1.00 AI623759 0.60 1.00 0.82 1
    206829_x_at2, 3 U133-A 2 1.00 0.95 -- -- NM_025189 0.60 1.00 0.82 1
    238614_x_at2, 3 U133-B 1 0.36 1.00 -- -- AW954842 0.40 1.00 0.76 1
    206829_x_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    238614_x_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    ZNF430 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZNF430 gene expression
    ZNF430 gene electronic northern expression
    ZNF430 gene sage expression
    About these images

    CGAP SAGE TAG: AAAAAGCCAT

    SOURCE GeneReport for Unigene cluster: Hs.466289
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF430
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF430: PPH16726A
        SABiosciences Custom PCR Arrays for ZNF430 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ZNF430 gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ZNF4301   -- zinc finger protein 430 99(n)
    98.24(a)
    737637  XM_001144468.1  XP_001144468.1 
    About this table        Species with no ortholog for ZNF430

    ENSEMBL Gene Tree for ZNF430 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZNF430 gene
    ZNF852  ZNF4932  ZNF7332  ZNF1952  ZNF1002  ZNF922  ZNF6752  ZNF7322  
    ZNF1382  ZNF5062  ZNF2732  ZNF6952  ZNF6262  ZNF432  ZNF6802  ZNF4922  
    ZNF6822  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF2572  ZNF2542  ZNF7372  
    ZNF724P2  ZNF982  ZNF7352  ENSG000001602292  ZNF7162  ZNF7142  ZNF5192  ZNF4292  
    ZNF7302  ZNF6782  ZNF1172  ZNF7082  ZNF4312  ZNF902  ZNF7262  

    ZNF430 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/461 NCBI SNPs in ZNF430 are shown (see all 461)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10547031,2
    --21242665(+) AAGATA/GCATGA 2 -- ut310--------
    rs14700201,2
    C,21217211(+) TTGCTG/ATCAGA 2 -- int18Minor allele frequency- A:0.01MN EA NA WA 286
    rs18663841,2
    C,H,21208079(+) aaagtA/Catttt 2 -- int17Minor allele frequency- C:0.00NA WA 16
    rs19718151,2
    C21232813(+) cctccT/Cgagta 2 -- int14Minor allele frequency- C:0.12NA 8
    rs20810501,2
    C,A,H21211673(-) ctttaC/Ttaaaa 2 -- int17Minor allele frequency- T:0.01EA NA WA 62
    rs20810521,2
    C,H21207517(-) GCTCCG/ACCTCC 2 -- int16Minor allele frequency- A:0.00NA WA 14
    rs20810541,2
    C,F,A,H,21203552(-) cctgcA/Gggtca 3 -- ut51 ese312Minor allele frequency- G:0.16EA NS NA WA 1924
    rs20986811,2
    C,A,21208319(-) acctaC/Tggggc 2 -- int16Minor allele frequency- T:0.00NA WA 12
    rs20986821,2
    C,A,21203196(-) atgcaC/Tttata 2 -- ng510--------
    rs21649871,2
    C,A21225588(+) actccG/Atctaa 2 -- int14Minor allele frequency- A:0.00NA WA 8
    About this table

    HapMap Linkage Disequilibrium images for ZNF430 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZNF430
         1 Indel: 26216

    QIAGEN SeqTarget long-range PCR primers for resequencing ZNF430 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    5 PubMed articles for ZNF430 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with ZNF430)
    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80264 HGNC: 20808 AceView: ZNF430 Ensembl:ENSG00000118620 euGenes: HUgn80264
    ECgene: ZNF430 H-InvDB: ZNF430

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ZNF430 gene:
    Search GeneIP for patents involving ZNF430

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF430
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     Regulatory tfbs in ZNF430 promoter
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    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    ZNF430 gene at Home site.
    hostname: genecards db genecards_305 index build: 81e solr: 1.4