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ZNF682 Gene

protein-coding   GIFtS: 37

GC19M019677
zinc finger protein 682
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for ZNF682 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
zinc finger protein 6821 2
BC39498_31 2
FLJ903622

External Ids:    HGNC: 288571   Entrez Gene: 911202   Ensembl: ENSG000001971247   UniProtKB: O957803   

Export aliases for ZNF682 gene to outside databases

Previous GC identifers: GC19M019978 GC19M020115


Summaries
for ZNF682 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780
Function: May be involved in transcriptional regulation


Genomic Views
for ZNF682 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF682 gene promoter:
         LCR-F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF682

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF682 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF682 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019677:  view genomic region     (about GC identifiers)

Start:
 19,677,131 bp from pter
End:
 19,712,471 bp from pter
Size:
 35,341 bases
Orientation:
 minus strand

1 alternative location:
Chr19- 20,115,227-20,150,277     
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  

Proteins
for ZNF682 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780 (See protein sequence)
Recommended Name: Zinc finger protein 682  
Size: 498 amino acids; 58361 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB55408.1; Type=Frameshift; Positions=441;
Secondary accessions: B3KU64 Q96JV9
Alternative splicing: 2 isoforms:  O95780-1   O95780-2   

Explore the universe of human proteins at neXtProt for ZNF682: NX_O95780 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001070817.1  NP_149973.1  


    ENSEMBL proteins: 
    ENSP00000380348 ENSP00000380351 ENSP00000351324 


    Human Recombinant Proteins 
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    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    ZNF682 for ontologies           About GeneDecksing



    Antibodies for ZNF682: 
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    Assays for ZNF682: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for ZNF682 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZNF682 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O95780

    ProtoNet protein and cluster: O95780

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Gene Function
    for ZNF682 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780
    Function: May be involved in transcriptional regulation

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZNF682
    Sigma-Aldrich shRNA for ZNF682
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZNF682
    OriGene shRNA RFP (see all 2): ZNF682
    OriGene basic RS shRNA (see all 2): ZNF682
    OriGene siRNA (see all 2): ZNF682
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF682 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF682 
    Search SABiosciences for Assays for microRNAs that regulate ZNF682

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ZNF682
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZNF682
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZNF682
    OriGene 3'-UTR clone (see all 2): ZNF682 
    Browse MicroRNA Expression Plasmids 
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    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for ZNF682 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    ZNF682 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ZNF682 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ZNF682 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF682

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table

    ZNF682 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZNF682 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF682


    Transcripts
    for ZNF682 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ZNF682
    Sigma-Aldrich shRNA for ZNF682
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): ZNF682
    OriGene shRNA RFP (see all 2): ZNF682
    OriGene basic RS shRNA (see all 2): ZNF682
    OriGene siRNA (see all 2): ZNF682
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF682 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF682 
    Search SABiosciences for Assays for microRNAs that regulate ZNF682
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): ZNF682
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ZNF682
    OriGene untagged cDNA clones in CMV expression vector (see all 2): ZNF682
    OriGene 3'-UTR Clone (see all 2): ZNF682 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNF682 
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF682
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF682: PPH16612A

    REFSEQ mRNAs for ZNF682 gene (2 alternative transcripts): 

    NM_001077349.1  NM_033196.2  

    Additional cDNA sequence: 

    AK027845.1 AK074843.1 AK096571.1 AK098164.1 AK127015.1 BC136304.1 

    10 DOTS entries:

    DT.121493182  DT.91665271  DT.121493259  DT.75117522  DT.91841371  DT.100020145  DT.75158609  DT.121492517 
    DT.121492982  DT.91877505 

    19 AceView cDNA sequences:

    AW237009 AK027845 AK098164 NM_033196 AW300489 AK127015 AK096571 AK074843 
    CA413972 BG485458 BG826709 BX283797 AI680077 AI831819 AA603590 N84282 
    AW293232 AA210630 N87781 

    highest scoring ESTs for ZNF682:

    AK027845 AK096571 AK098164 AA603590 AI680077 AK074843 AK127015 AW237009 AW293232 BG485458 

    Unigene Cluster for ZNF682:

    Zinc finger protein 682
    Hs.306298  [show with all ESTs]
    Unigene Representative Sequence: AK127015


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397162(uc002noo.2 uc002nop.2) ENST00000397165 ENST00000358523(uc002noq.2 uc010eck.2)


    Expression
    for ZNF682 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZNF682 expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching ZNF682 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    216468_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    242915_at2, 3 U133-B 1 0.91 1.00 -- -- AA603590 0.60 1.00 0.82 1
    216468_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    242915_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ZNF682 gene expression
    ZNF682 gene electronic northern expression
    ZNF682 gene sage expression
    About these images

    CGAP SAGE TAG: AGATAGATGT

    SOURCE GeneReport for Unigene cluster: Hs.306298
    Primers: OriGene genome-wide validated SYBR primer pairs: ZNF682
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF682: PPH16612A
        SABiosciences Custom PCR Arrays for ZNF682 


    Orthologs
    for ZNF682 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ZNF682 gene from 1 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ZNF6821   -- zinc finger protein 682 71.27(n)
    58.17(a)    		 484323  XM_541439.2  XP_541439.2 
    About this table        Species with no ortholog for ZNF682

    ENSEMBL Gene Tree for ZNF682 (if available)

    Paralogs
    for ZNF682 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZNF682 gene
    ZNF852  ZNF4932  ZNF7332  ZNF1952  ZNF1002  ZNF922  ZNF6752  ZNF7322  
    ZNF1382  ZNF5062  ZNF2732  ZNF6952  ZNF6262  ZNF432  ZNF6802  ZNF4922  
    ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF2572  ZNF2542  ZNF7372  ZNF724P2  
    ZNF982  ZNF7352  ENSG000001602292  ZNF7162  ZNF7142  ZNF5192  ZNF4292  ZNF4302  
    ZNF7302  ZNF6782  ZNF1172  ZNF7082  ZNF4312  ZNF902  ZNF7262  

    ZNF682 for paralogs           About GeneDecksing



    Genomic Variants
    for ZNF682 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/398 NCBI SNPs in ZNF682 are shown (see all 398)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs9633801,2
    		C,F,H,20143753(+) ggtacC/Ttgctg 2 -- int112Minor allele frequency- T:0.29NS EA NA WA 494
    rs9930441,2
    		C,A,H,20147085(+) TTCTGC/TATCTG 2 -- int19Minor allele frequency- T:0.29NA EA WA 222
    rs11213871,2
    		C,A,H,20150794(+) GGCGTC/GGTAGC 2 -- ng5110Minor allele frequency- G:0.33NA EA WA 226
    rs11213881,2
    		C,A,H,20150819(+) CTAGCT/AACTAG 2 -- ng519Minor allele frequency- A:0.35NA EA WA 176
    rs13194791,2
    		C,F,20147142(+) GTTTTT/CTGAGA 2 -- int111Minor allele frequency- C:0.25NS EA NA WA 496
    rs19874081,2
    		C,H20143949(+) tgggcG/Acctgt 2 -- int15Minor allele frequency- A:0.00NA 12
    rs20177211,2
    		C,H20143908(+) cgcctC/Ttacta 2 -- int15Minor allele frequency- T:0.00NA 10
    rs20416061,2
    		C,20144384(+) tgagaC/Tggagt 2 -- int16Minor allele frequency- T:0.00NA WA 12
    rs20750901,2
    		C,F,20117685(+) TAAAGG/ATTTTG 4 /T /I ref1 mis117Minor allele frequency- A:0.15EA NS NA WA 2542
    rs21101241,2
    		C20144533(+) ATTTTC/ATGTAT 2 -- int13Minor allele frequency- A:0.00NA 6
    About this table

    HapMap Linkage Disequilibrium images for ZNF682 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF682: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ZNF682 

    Disorders & Mutations
    for ZNF682 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Medical News
    for ZNF682 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for ZNF682 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    4 PubMed articles for ZNF682 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with ZNF682)
    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ZNF682 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZNF682 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91120 HGNC: 28857 AceView: LOC91120 Ensembl:ENSG00000197124 euGenes: HUgn91120
    ECgene: ZNF682 H-InvDB: ZNF682

    Other Databases showing ZNF682 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZNF682 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for ZNF682 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for ZNF682 gene:
    Search GeneIP for patents involving ZNF682

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZNF682 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     Regulatory tfbs in ZNF682 promoter
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    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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    ZNF682 gene at Home site.
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