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ZNF716 Gene

protein-coding   GIFtS: 34

GC07P057110
zinc finger protein 716
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
zinc finger protein 7161 2
FLJ461891 2
OTTHUMP000002104112

External Ids:    HGNC: 324581   Entrez Gene: 4412342   Ensembl: ENSG000001821117   UniProtKB: A6NP113   

Export aliases for ZNF716 gene to outside databases

Previous GC identifers: GC07P057321 GC07P057501


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11
Function: May be involved in transcriptional regulation


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF716 gene promoter:
         POU2F1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   c-Myb   AP-4   AREB6   E47   Lmo2   PPAR-gamma2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ZNF716

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11.1

ZNF716 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF716 gene location

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P057110:  view genomic region     (about GC identifiers)

Start:
57,110,288 bp from pter
End:
57,133,368 bp from pter
Size:
23,081 bases
Orientation:
plus strand

1 alternative location:
Chr7+ 57,509,883-57,533,265     
RefSeq DNA sequence:
NC_000007.13  NT_033968.6  NT_079592.2  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11 (See protein sequence)
Recommended Name: Zinc finger protein 716  
Size: 483 amino acids; 55742 Da
Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ZNF716: NX_A6NP11 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001152751.1  

    ENSEMBL proteins: 
    ENSP00000394248 ENSP00000387687 


    Human Recombinant Proteins 
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    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    ZNF716 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF716 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry A6NP11

    ProtoNet protein and cluster: A6NP11

    UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ZN716_HUMAN, A6NP11
    Function: May be involved in transcriptional regulation

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    miRNA:Browse microRNA Mimics at Sigma-Aldrich
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF716 
    Search SABiosciences for Assays for microRNAs that regulate ZNF716

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZNF716
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF716
    OriGene 3'-UTR clone: ZNF716 
    Browse MicroRNA Expression Plasmids 
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    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ZNF716 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    ZNF716 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for ZNF716 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF716

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table

    ZNF716 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF716


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for ZNF716
    Sigma-Aldrich shRNA for ZNF716
    Browse OriGene 29mer shRNA kits
    OriGene siRNA (see all 4): ZNF716
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ZNF716 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ZNF716 
    Search SABiosciences for Assays for microRNAs that regulate ZNF716
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ZNF716
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ZNF716
    OriGene 3'-UTR Clone: ZNF716 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for ZNF716 
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF716: PPH60681A

    REFSEQ mRNAs for ZNF716 gene: 

    NM_001159279.1  

    Additional cDNA sequence: 

    AK131575.1 XM_002342727.1 

    2 DOTS entries:

    DT.102834270  DT.95373561 

    1 AceView cDNA sequence:

    AK131575 

    highest scoring ESTs for ZNF716:

    AK131575 DB064525 XM_496879 BF085321 

    Unigene Cluster for ZNF716:

    Zinc finger protein 716
    Hs.533121  [show with all ESTs]
    Unigene Representative Sequence: NM_001159279


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420713(uc011kdi.1) ENST00000418732

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ZNF716 expression in normal and diseased human tissues

    1 Data from GNF BioGPS
        About these images

    ZNF716 gene expression
    ZNF716 gene electronic northern expression
    ZNF716 gene sage expression
    About these images

    CGAP SAGE TAG: GTCCCAGTTA

    SOURCE GeneReport for Unigene cluster: Hs.533121
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ZNF716: PPH60681A
        SABiosciences Custom PCR Arrays for ZNF716 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ZNF716 gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ZNF7161   -- zinc finger protein 716 98.3(n)
    97.33(a)
    472380  XM_527754.2  XP_527754.2 
    About this table        Species with no ortholog for ZNF716

    ENSEMBL Gene Tree for ZNF716 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ZNF716 gene
    ZNF852  ZNF4932  ZNF7332  ZNF1952  ZNF1002  ZNF922  ZNF6752  ZNF7322  
    ZNF1382  ZNF5062  ZNF2732  ZNF6952  ZNF6262  ZNF432  ZNF6802  ZNF4922  
    ZNF6822  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF2572  ZNF2542  ZNF7372  
    ZNF724P2  ZNF982  ZNF7352  ENSG000001602292  ZNF7142  ZNF5192  ZNF4292  ZNF4302  
    ZNF7302  ZNF6782  ZNF1172  ZNF7082  ZNF4312  ZNF902  ZNF7262  

    ZNF716 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for ZNF716
         6 CNVs: 53442 8561 2695 8560 8559 52262
    QIAGEN SeqTarget long-range PCR primers for resequencing ZNF716 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    2 PubMed articles for ZNF716 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with ZNF716)
    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 441234 HGNC: 32458 AceView: LOC441234 Ensembl:ENSG00000182111 euGenes: HUgn441234
    ECgene: ZNF716 H-InvDB: ZNF716

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ZNF716 gene:
    Search GeneIP for patents involving ZNF716

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     SeqTarget long-range PCR primers for resequencing ZNF716
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
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     Regulatory tfbs in ZNF716 promoter
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