Su X, Zhang L, Zhang J, Meric-Bernstam F, Weinstein J
Department of Bioinformatics and Computational Biology, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
SUMMARY: We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing data sets and demonstrated the accuracy of PurityEst compared to DNA copy number-based estimation. AVAILABILITY: PurityEst has been implemented in PERL and is available at http://odin.mdacc.tmc.edu/~xsu1/PurityEst.html CONTACT: firstname.lastname@example.org.