|Description||A bioinformatics web app for detecting positive selection in proteins using a sliding window substitution rate analysis. Click the link below to use SWAKK.|
|Citations|| Liang H, Zhou W, Landweber L. (2006).|
SWAKK: a web server for detecting positive selection in proteins using a sliding window substitution rate analysis.
Nucleic Acids Research 34:Suppl2 W382-384.
|News||Updated codebase from Princeton migration.|
|Help and Support|
SWAKK is a valuable bioinformatic tool for detecting amino acid sites or regions of a protein under positive selection. It estimates the ratio of non-synonymous to synonymous substitution rates (Ka/Ks) between a pair of protein-coding DNA sequences, by sliding a 3D window, or sphere, across one reference structure. The program displays the results on the 3D protein structure. In addition, for comparison or when a reference structure is unavailable, the web app can also perform a sliding window analysis on the primary sequence.
Login is not required — it is free for anyone to use.
For questions or support related to the use of SWAKK, please visit on the project's forum page.
For other inquiries, please contact Dr. Han Liang.
This website is for educational and research purposes only.