LFSPRO
TP53 germline mutations are the main cause of Li-Fraumeni Syndrome (opens in new tab). This package is designed to estimate probabilities that: 1) the counselee is a TP53 germline mutation carrier, 2) the counselee develops any cancer in future, 3) the counselee develops breast cancer, sarcoma or any other cancers in future, 4) the counselee develops a first or second primary cancer in future, on the basis of his/her family cancer history. The package also provides functions for using the LFS classic1 and Chompret criteria2,3.
For comprehensive information on installation, usage, and additional resources, please refer to our GitHub page:
https://github.com/wwylab/LFSPRO (opens in new tab)
Contact
Reference
- Li FP, Fraumeni JF, Jr., Mulvihill JJ, et al. A cancer family syndrome in twenty-four kindreds. Cancer research. Sep 15 1988;48(18):5358-5362. (opens in new tab) [return]
- Chompret A, Abel A, Stoppa-Lyonnet D, et al. Sensitivity and predictive value of criteria for p53 germline mutation screening. Journal of medical genetics. Jan 2001;38(1):43-47. https://dx.doi.org/10.1136%2Fjmg.38.1.43 (opens in new tab) [return]
- Tinat J, Bougeard G, Baert-Desurmont S, et al. 2009 version of the Chompret criteria for Li Fraumeni syndrome. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. Sep 10 2009;27(26):e108-109; author reply e110. https://doi.org/10.1200/JCO.2009.22.7967 (opens in new tab) [return]