|Description||A bioinformatics web app for detecting positive selection in proteins using a sliding window substitution rate analysis. Click the link below to use SWAKK.|
|News||Updated codebase from Princeton migration.|
|Citation||Han Liang, Weihua Zhou, Laura F. Landweber; SWAKK: a web server for detecting positive selection in proteins using a sliding window substitution rate analysis, Nucleic Acids Research, Volume 34, Issue suppl_2, 1 July 2006, Pages W382–W384 https://doi.org/10.1093/nar/gkl272|
|Help and Support|
SWAKK is a valuable bioinformatic tool for detecting amino acid sites or regions of a protein under positive selection. It estimates the ratio of non-synonymous to synonymous substitution rates (Ka/Ks) between a pair of protein-coding DNA sequences, by sliding a 3D window, or sphere, across one reference structure. The program displays the results on the 3D protein structure. In addition, for comparison or when a reference structure is unavailable, the web app can also perform a sliding window analysis on the primary sequence.
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