Section of Bioinformatics

Established in January 2000, the Bioinformatics Section is comprised of a core of researchers and analysts within the Department of Bioinformatics and Computational Biology inside the Division of Quantitative Sciences. Bioinformatics is an integral component of the Cancer Genomics Program at the University of Texas M. D. Anderson Cancer Center. As such, it interacts closely with the Cancer Genomics Microarray Core Laboratory, the Murine Microarray and Affymetrix Facility, the Proteomics Facility, and the Kleberg Center for Molecular Markers.

Members of the Bioinformatics Section staff the Bioinformatics Shared Resource, which is supported in part by the Cancer Center Support Grant.

Mission

The Bioinformatics group will develop statistically rigorous solutions for the design and analysis of experiments at M.D. Anderson involving large data sets produced by high-throughput technologies in biology, and will provide data analysis, acquisition, curation, and retrieval tools.

Current Projects

• Combining drug sensitivity results with gene expression profiles
• Discovering and validating cancer signatures in reverse-phase protein lysate array (RPPA) data
• Better quantifications and processing of RPPA data
• Analysis of methylation arrays
• Searching for alternative splicing using exon arrays
• Sample size computations for microarray and proteomics profiling experiments
• Low-level processing of mass spectrometry proteomics data