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DescriptionREcurrent Features LEveraged for Combination Therapy
Development Information
LanguageR, Python and JavaScript
Current version1.0
PlatformsPlatform independent
LicenseSee Terms of Use
Last updatedJanuary 24, 2020
Help and Support
Contact Anil Korkut 


REFLECT, abbreviated form of “Recurrent Features Leveraged for Combination Therapy”, is to accelerate discovery of combination therapies tailored to multi-omic profiles of cancer patient cohorts with matching oncogenic features. REFLECT identifies co-actionable, co-occurring oncogenic alterations that are recurrent within patient cohorts using genomic, transcriptomic and phosphoproteomic data. The REFLECT predictions are testable hypotheses on responses to drug combinations in specific patient cohorts matched to co-actionable alterations. The analysis of proteomic and transcriptomic signatures in relation to the variant information in patient cohorts also enable prediction of functional rare variants. This REFLECT-based online resource captures co-occurrence analyses of 190 patient cohorts each identified by a potentially actionable aberration. REFLECT provides a novel, robust and widely applicable precision medicine approach and resource for matching oncogenic alterations to combination therapies.

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Release History

Terms of Use

MD Anderson makes no warranties or representations, express or implied, with respect to any of the content, including as to the present accuracy, completeness, timeliness, adequacy, or usefulness of any of the content and MD Anderson will not be liable for any loss or damages arising from your use of or reliance on information contained in this site or other sites that may be linked to from our site. You may view the content contained on REFLECT solely for your own personal, non-commercial purposes. You may not copy, transfer, reproduce, modify, or create derivative works of any part of the REFLECT content for any reason and you may not use the REFLECT content for any commercial purpose (e.g., you may not distribute, license or sell the content, alone or in combination with other materials, to any other person or entity) without the express written permission of MD Anderson. For commercial licensing inquiries, please contact us at


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