Below are specific supplements, which may include figures, tables, data, and/or analysis code for manuscripts published by researchers at MD Anderson:
PanCan 11
Supplementary data in support of the paper: A pan-cancer proteomic perspective on The Cancer Genome Atlas,
by Akbani R, Ng PKS, Werner HMJ, et al. Nature Communications 2014; 5:3877.
PanCan 12 Subtypes
Supplementary data in support of the paper: Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin,
by Hoadley KA, Yao C, Wolf DM, et al., Cell 2014; 158(4):929-944.
Chemosensitivity and Cell Lines
Supplementary data in support of the paper:Deriving Chemosensitivity from Cell Lines: Forensic Bioinformaticsand Reproducible Research in High-Throughput Biology, by Baggerly KA
and Coombes KR, Annals of Applied Statistics 2009; 3(4):1309-1334.
Alternative Splicing in Glioblastoma
Supplementary datasets in support of the paper:Global Analysis of
Aberrant pre-mRNA Splicing in Glioblastoma Using Exon Expression
Arrays, by Cheung HC, Baggerly KA, Tsavachidis S, Bachinski LL,
Neubauer VL, Nixon TJ, Aldape KD, Cote GJ, Krahe R. These include
CEL files for 24 glioblastoma samples (around 550Mb
zipped), CEL files for 12 normal brain samples (around 266Mb
zipped), and a text file with file names and tumor/normal status
(1K).
Topographical Normalization
Supplementary dataset, containing code and data in support of the
paper:Topographical Normalization of Reverse Phase Protein Arrays,
by Neeley ES, Baggerly KA, Kornblau SM.
RPPA Data for Variable Slope Normalization
Supplementary dataset, containing code and clinical and RPPA protein
datain support of the paper: Variable Slope Normalization of Reverse
Phase Protein Arrays, by Neeley ES, Kornblau SM, Coombes KR,
Baggerly KA.
RPPA Data in AML
Supplementary dataset, containing clinical and RPPA protein data on
256 newly diagnosed AML patients, in support of the
paper: Functional Proteomic Profiling of AML Predicts Response
and Survival, by Kornblau SM, Tibes R, Qiu YH, CHen W, Kantarjian
H, Andreeff M, Coombes KR, Mills GB. Blood, to appear.
Run Batch Effects and Ovarian Cancer
Complete source code and results for the analysis described in: Run
batch effects potentially compromise the usefulness of
genomicsignatures for ovarian cancer, by Baggerly KA, Neeley ES,
Coombes KR. J Clin Oncol. 2008; 26(7):1186-1187.
Dressman et al. replied to our correspondence. Our
own reply-to-their-reply wil be posted on our
addendum
to our first web site.
(Ir)reproducibility of chemopredictors
Complete source code and results for the analysis described
in: Microarrays: retracing steps, by Coombes KR, Wang J,
Baggerly KA. Nature Medicine. 2007; 3(11):1276-1277.
(Formerlyknown as: Genomic signatures based on the NCI60 cell lines
do notpredict patient response to chemotherapy.)
Potti and Nevins replied to our correspondence. Our
own reply-to-their-reply can be found on our
addendum to our first web site.
Microenvironment Gene List
Supplementary table for: Gene Expression Profile of Metastatic Human
Pancreatic Cancer Cells Depends on the Organ Microenvironment, by
Najamura T, Fidler IJ, Coombes KR. Cancer Res. 2007; 67:139-48.
Wavelet-Based Functional Mixed Models
Supplementary material, including description of
Metroplis-Hastingsand some MCMC trace plots, for Wavelet-based
Functional Mixed Models by Morris and Carroll.
UniGene Affiliation
Supplementary material for Gene Sequence Signatures Revealed by
Mining the UniGene Affiliation Network, by Zhang J, Zhang L, Coombes
KR. Bioinformatics. 2006; 22:385-91
Validation by QRT-PCR on Low-Density Arrays
Supplementary figures and data Validation of oligonucleotide
microarray data using microfluidiclow-density arrays: a new
statistical method to normalize real-timeRT-PCR
data,
by Abruzzo LV, Lee KY, Fuller A, Silverman A, Keating MJ,
Medeiros LJ, Coombes KR. Biotechniques. 2005; 38:785-92
List of Significant Peaks in Pancreatic Cancer
Supplementary Table S1 for: Plasma Protein Profiling for Diagnosis
of Pancreatic Cancer Reveals the Presence of Host Response Proteins.
by Koomen JM, Shih LN, Coombes KR, Li D, Xiao LC, Fidler IJ,
Abbruzzese JL, Kobayashi R.Clin Cancer Res. 2005;
11:1110-1118.
Peak detection for MALDI using the average spectrum
Supplementary material for Feature Extraction and Quantification for
Mass Spectrometry Data in Biomedical Applications Using the Mean
Spectrum, by Morris JS, Coombes KR, Kooman J, Baggerly KA, and
Kobayashi R. Bioinformatics 2005; 21:1764-75.
Diagnostic Protein Discovery using LCMS for Proteolytic Peptide Targeting
Supplementary material for: Diagnostic Protein Discovery using
Proteolytic Peptide Targeting and Identification, by John M. Koomen,
Haitao Zhao, Donghui Li, James L. Abbruzzese, Keith A. Baggerly,
Ryuji Kobayashi. Rapid Communications in Mass Spectrometry,
2005; 18:2537-48.
Reproducibility of SELDI-TOF
Supplementary material, including Matlab and Perl code and additional
Figures to accompany Reproducibility of SELDI-TOF protein patterns
in serum: comparing datasets from different
experiments,
by Baggerly KA, Morris JS, Coombes KR. Bioinformatics
2004; 20:777-85
Signal in Noise
Supplementary material, including Matlab scripts and processed data
to accompany Signal in noise: evaluating reported reproducibility of
serum proteomic tests for ovarian cancer, by Baggerly KA, Edmonson
SR, Morris JS, Coombes KR. Endocr Relat Cancer. 2004; 11:583-4
Processing Proteomics Spectra, Version 1
Supplements to: Quality control and peak finding for proteomics data
collected from nipple aspirate fluid by surface-enhanced laser
desorption and ionization, by Coombes KR, Fritsche HA Jr, Clarke C,
Chen JN, Baggerly KA, Morris JS, Xiao LC, Hung MC, Kuerer HM.
ClinChem. 2003; 49:1615-23
Between Library Variation in SAGE
Supplements to: Differential expression in SAGE: accounting for normal between-library variation,
by Baggerly KA, Deng L, Morris JS, Aldaz CM. Bioinformatics.
2003; 19:1477-83.
CAMDA 2001 Supplement
Supplementary material for our presentation at CAMDA 2001
PCANOVA
Description of the PCANOVA method for evaluating the amount of group
structure present in microarray data.
EGFR.signature.zip
Supplementary material for the EGFR.signature.